{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:27:55Z","timestamp":1787984875407,"version":"build-2784847793"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal Society of New Zealand"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hereditary Diffuse Gastric Cancer (HDGC) is a high risk cancer syndrome caused predominantly by germline mutations in the\n                    <jats:italic>CDH1<\/jats:italic>\n                    gene. HDGC is characterised by a lifetime risk of advanced diffuse\u2010type gastric (stomach) cancer of up to 70%, and an additional 40% lifetime risk of lobular breast cancer in women. Since the first description of HDGC in three wh\u0101nau M\u0101ori in 1998, our understanding of this syndrome's life history and clinical behaviour has steadily evolved, leading to changes to its clinical management. In particular, it is now evident that the signet ring cell carcinomas that develop in the stomachs of\n                    <jats:italic>CDH1<\/jats:italic>\n                    pathogenic variant carriers have an indolent phase, although the factors that drive progression of these early cancers to advanced disease remain to be identified. This indolent phase provides the opportunity for chemoprevention to be considered as an alternative to prophylactic surgery as a risk reduction strategy. Here, we describe the evolution of our knowledge of HDGC, with particular reference to the syndrome's penetrance, tumour spectrum and pathology.\n                  <\/jats:p>","DOI":"10.1080\/03036758.2025.2511007","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T21:08:12Z","timestamp":1750108092000},"page":"2636-2651","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Hereditary diffuse gastric cancer: the evolution of a cancer syndrome"],"prefix":"10.1002","volume":"55","author":[{"given":"Lyvianne","family":"Decourtye\u2010Espiard","sequence":"first","affiliation":[{"name":"Cancer Genetics Laboratory, Te Aho Matat\u016b Department of Biochemistry, Ot\u0101kou Whakaihu Waka University of Otago Dunedin (Otepoti) New Zealand (Aotearoa)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanis","family":"Godwin","sequence":"additional","affiliation":[{"name":"Cancer Genetics Laboratory, Te Aho Matat\u016b Department of Biochemistry, Ot\u0101kou Whakaihu Waka University of Otago Dunedin (Otepoti) New Zealand (Aotearoa)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parry","family":"Guilford","sequence":"additional","affiliation":[{"name":"Cancer Genetics Laboratory, Te Aho Matat\u016b Department of Biochemistry, Ot\u0101kou Whakaihu Waka University of Otago Dunedin (Otepoti) New Zealand (Aotearoa)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30219\u20109"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010175"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091359"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010102"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.36.12.873"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/0102\u20106720202400019e1812"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2002.010447"},{"key":"e_1_2_13_9_1","unstructured":"ClinVar.2024.https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/."},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010022\u201000309\u2010w"},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","unstructured":"CoudertM DrouetY DelhomelleH SvrcekM BenusiglioPR CouletF ClarkDF KatonaBW vanHestLP van derKolkLEet al.2022.First estimates of diffuse gastric cancer risks for carriers of CTNNA1 germline pathogenic variants. J Med Genet.","DOI":"10.1136\/jmg-2022-108740"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1580\u20101583.2003"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010175"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.01.038"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddab004"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000001100"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6354"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(18)30079\u20107"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)90546\u20103"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.074237"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.5118"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(22)00643\u2010X"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010018\u20100859\u20101"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201023\u20100122"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/32918"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1999)14:3<249::AID-HUMU8>3.0.CO;2-9"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14228"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2014.168"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.039"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201008\u20102457"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201006\u20103021"},{"key":"e_1_2_13_32_1","first-page":"287","article-title":"Familial gastric cancer","volume":"63","author":"Jones EG.","year":"1964","journal-title":"N Z Med J"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010012\u20109595\u20106"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2790"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12102102"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(22)00700\u20108"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.45836"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2021.104316"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annpat.2021.04.004"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010021\u201003061\u20101"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3878"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4152"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010018\u20100304\u20102"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)81070\u20103"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.23048"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.0476"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188719"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207714"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00438"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2024.328"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp046"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8484120"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29611"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1208"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13715"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102699.2009.02139.x"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.10852"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.010"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.266798"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adg5289"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010024\u201016117\u20108"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010013\u20100278\u20102"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.230195"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201014\u20101092"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211807"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(23)00094\u20103"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet\u20102015\u2010103094"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010008\u20108281\u20101"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2983"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1913.00070050063006"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet\u20102019\u2010105991"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010013\u20100298\u2010y"}],"container-title":["Journal of the Royal Society of New Zealand"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rsnz.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/03036758.2025.2511007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rsnz.onlinelibrary.wiley.com\/doi\/full-xml\/10.1080\/03036758.2025.2511007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rsnz.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/03036758.2025.2511007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:56:48Z","timestamp":1769345808000},"score":1,"resource":{"primary":{"URL":"https:\/\/rsnz.onlinelibrary.wiley.com\/doi\/10.1080\/03036758.2025.2511007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1080\/03036758.2025.2511007"],"URL":"https:\/\/doi.org\/10.1080\/03036758.2025.2511007","archive":["Portico"],"relation":{},"ISSN":["0303-6758","1175-8899"],"issn-type":[{"value":"0303-6758","type":"print"},{"value":"1175-8899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tnzr20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tnzr20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}