{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:44:29Z","timestamp":1790919869437,"version":"4.1.0"},"reference-count":72,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Aging Research"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1080\/03610730252800166","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T11:29:43Z","timestamp":1027682983000},"page":"143-162","source":"Crossref","is-referenced-by-count":55,"title":["Pathological Determinants of the Transition to Clinical Dementia in Alzheimer's Disease"],"prefix":"10.1080","volume":"28","author":[{"given":"Donald R.","family":"Royall","sequence":"first","affiliation":[{"name":"a \r\r Departments of Psychiatry, Medicine, and Pharmacology South Texas Veterans' Health System, Audie L. Murphy Division GRECC, and the University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Palmer","sequence":"additional","affiliation":[{"name":"b \r\r Department of Family Practice, University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Mulroy","sequence":"additional","affiliation":[{"name":"c \r\r Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha J.","family":"Polk","sequence":"additional","affiliation":[{"name":"c \r\r Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo C.","family":"Rom\u00e1n","sequence":"additional","affiliation":[{"name":"d \r\r Department of Medicine, South Texas Veterans' Health System, Audie L. Murphy Division GRECC, and the University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Phillippe","family":"David","sequence":"additional","affiliation":[{"name":"e \r\r Emile Roux Hospital, Limeil-Br\u00e9vannes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Delacourte","sequence":"additional","affiliation":[{"name":"f \r\r Unit\u00e9 INSERM Service de Neurologie, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2010,11,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"189198","article-title":"'Mini-Mental State': A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Holstein M.","year":"1975","unstructured":"Holstein , M. , Holstein , S. and McHugh , P. R. 1975 . 'Mini-Mental State': A practical method for grading the cognitive state of patients for the clinician . Psychiatric Research , 12 : 189198","journal-title":"Psychiatric Research"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.512.797"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.3.229"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.631"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540040011008"},{"key":"e_1_2_1_7_1","first-page":"21","article-title":"Relative roles of plaques and tangles in dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria","volume":"6","author":"Nagy Z.","year":"1995","unstructured":"Nagy , Z. , Esiri , M. M. , Jobst , K. A. , Morris , J. H. , King , E. , McDonald , B. , Litchfield , S. , Smith , A. , Barnetson , L. and Smith , A. D. 1995 . Relative roles of plaques and tangles in dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria . Dementia , 6 : 21 \u2013 31 .","journal-title":"Dementia"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.3.326"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270502"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6852"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.6.713"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.13.4531"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.1989.2.2.101"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(93)90015-4"},{"key":"e_1_2_1_16_1","first-page":"585","volume-title":"Neurodegenerative diseases","author":"Braak H.","year":"1994","unstructured":"Braak , H. and Braak , E. 1994 . \u201c Pathology of Alzheimer's disease \u201d . In Neurodegenerative diseases , Edited by: Calne , D. B. 585 \u2013 613 . Philadelphia : W. B. Saunders ."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)00021-6"},{"key":"e_1_2_1_18_1","first-page":"101","article-title":"Lack of continuum between cerebral aging and Alzheimer's disease as revealed by PHF-tau and A&szlig; biochemistry","volume":"1","author":"Delacourte A.","year":"1998","unstructured":"Delacourte , A. , Buee , L. , David , J. P. , Sergeant , N. , Wattez , A. , Vermersch , P. , Pasqirier , R , Lebert , R , Ghouzali , R , Fallet-Bianco , C. and DiMenza , C. 1998 . Lack of continuum between cerebral aging and Alzheimer's disease as revealed by PHF-tau and A&szlig; biochemistry . Alzheimer Reports , 1 : 101 \u2013 110 .","journal-title":"Alzheimer Reports"},{"key":"e_1_2_1_19_1","first-page":"228","article-title":"Tau pathology in aging and neurodegenerative disorders","volume":"3","author":"Delacourte A.","year":"1998","unstructured":"Delacourte , A. 1998 . Tau pathology in aging and neurodegenerative disorders . Current Research in Alzheimer's Disease , 3 : 228 \u2013 235 .","journal-title":"Current Research in Alzheimer's Disease"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199812000-00009"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781439821862"},{"key":"e_1_2_1_23_1","unstructured":"Graham J. Hofer S. & Piccinin A. (1994). Analysis with missing data in drug prevention research. In L. Collins and L. Seitz (Eds.) Advances in data analysis for prevention intervention research (pp. 13-63). NIDA Research Monograph 142. Washington DC: U.S. Dept. of Health and Human Services."},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","unstructured":"Gilks W. R. Richardson S. & Spiegelhalter D. J. (Eds.). (1996). Markov chain monte carlo in practice. London: Chapman & Hall.","DOI":"10.1201\/b14835"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1987.10478458"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049124189018002004"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1996.10476908"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327906mbr3304_5"},{"key":"e_1_2_1_30_1","unstructured":"Schafer J. L. (1998). NORM: Multiple imputation of incomplete multivariate data under a normal model (Version 2) [Software for Windows 95\/98\/NT available from http:\/\/www.stat.psu.edu\/\u223cjls\/misoftwa.html]."},{"key":"e_1_2_1_31_1","volume-title":"Classification and regression trees","author":"Breiman L.","year":"1984","unstructured":"Breiman , L. , Friedman , J. H. , Olshen , R. A. and Stone , C. J. 1984 . Classification and regression trees , Monterey, CA : Wadsworth & Brooks\/Cole Advanced Books & Software ."},{"key":"e_1_2_1_32_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"Psychiatric Association. American","year":"1994","unstructured":"Psychiatric Association. , American . 1994 . Diagnostic and statistical manual of mental disorders , 4th , Washington DC : American Psychiatric Press .","edition":"4"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.12.1571"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb38132.x"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.1999.10.1.49"},{"key":"e_1_2_1_36_1","first-page":"617","article-title":"Braak Stages III-IV of Alzheimer's related neuropathology are associated with mild memory loss","volume":"55","author":"Geddes J. W.","year":"1996","unstructured":"Geddes , J. W. , Snowdon , D. A. , Soultanian , N. S. , Terkirian , T. L. , Ripley , K. P. , Ashford , J. W. , Davis , D. G. and Markesbery , W. R. 1996 . Braak Stages III-IV of Alzheimer's related neuropathology are associated with mild memory loss . Stages V-VI are associated with dementia: Findings from the Nun Study. Journal of Neuropathology Experimental Neurology , 55 : 617","journal-title":"Stages V-VI are associated with dementia: Findings from the Nun Study. Journal of Neuropathology Experimental Neurology"},{"key":"e_1_2_1_37_1","first-page":"358","article-title":"Frontal-subcortical circuits and neuropsychiatrie disorders","volume":"6","author":"Mega M.","year":"1994","unstructured":"Mega , M. and Cummings , J. L. 1994 . Frontal-subcortical circuits and neuropsychiatrie disorders . Journal of Neurology, Neurosurgery, and Psychiatry , 6 : 358 \u2013 370 .","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1987.tb06349.x"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1996.tb02942.x"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410106"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1997.tb03091.x"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.9.1631"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.2.313"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540080076020"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550110056012"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540290075020"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(88)90118-9"},{"key":"e_1_2_1_48_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/978-1-4899-6704-6_22","volume-title":"Neuropsychology of cingulate cortex and limbic thalamus","author":"Braak H.","year":"1993","unstructured":"Braak , H. and Braak , E. 1993 . \u201c Alzheimer neuropathology and limbic circuits \u201d . In Neuropsychology of cingulate cortex and limbic thalamus , Edited by: Vogt , A. and Gabriel , M. 606 \u2013 626 . Boston : Birknauser ."},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540360028012"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1981.tb01818.x"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(83)90048-9"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2.4.373"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420114"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00841407"},{"key":"e_1_2_1_55_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/cercor\/2.6.435-a","article-title":"Functional heterogeneity in cingulate cortex: The anterior executive and posterior evaluative regions","volume":"2","author":"Vogt A.","year":"1992","unstructured":"Vogt , A. , Finch , D. M. and Olson , C. R. 1992 . Functional heterogeneity in cingulate cortex: The anterior executive and posterior evaluative regions . Cerebral Cortex , 2 : 435 \u2013 443 .","journal-title":"Cerebral Cortex"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237497"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510220014003"},{"key":"e_1_2_1_58_1","first-page":"273","article-title":"Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease","volume":"594","author":"Vickers J. C.","year":"1992","unstructured":"Vickers , J. C. , Delacourte , A. and Morrison , J. H. 1992 . Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease . Neuroscience Research , 594 : 273 \u2013 278 .","journal-title":"Neuroscience Research"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01337-X"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(95)00032-1"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.935"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb05087.x"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.10.1966"},{"key":"e_1_2_1_64_1","first-page":"371","article-title":"Strategic infarcts in vascular dementia","volume":"45","author":"Tatemichi T. K.","year":"1995","unstructured":"Tatemichi , T. K. , Desmont , D. W. and Prohovnik , I. 1995 . Strategic infarcts in vascular dementia . A clinical and imaging experience. Arzneimittelforschung , 45 : 371 \u2013 385 .","journal-title":"A clinical and imaging experience. Arzneimittelforschung"},{"key":"e_1_2_1_65_1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1098\/rstb.1996.0127","article-title":"Comparison of prefrontal architecture and connections","volume":"351","author":"Pandya D. N.","year":"1998","unstructured":"Pandya , D. N. and Sc. Yeterain , E. H. 1998 . Comparison of prefrontal architecture and connections . Philosophical Transactions of the Royal Society (London) B Biological Science , 351 : 1423 \u2013 1432 .","journal-title":"Philosophical Transactions of the Royal Society (London) B Biological Science"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.277.10.813"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199912001-00012"},{"key":"e_1_2_1_69_1","first-page":"12391248","article-title":"The functional roles of prefrontal cortex in episodic memory","volume":"121","author":"Fletcher P. C.","year":"1998","unstructured":"Fletcher , P. C. , Shallice , T. , Firth , C. D. , Frackowiak , R. S. and Dolan , R. J. 1998 . The functional roles of prefrontal cortex in episodic memory . I. Encoding. Brain , 121 : 12391248","journal-title":"I. Encoding. Brain"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/6.4.600"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.7.1249"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03327261"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.979"}],"container-title":["Experimental Aging Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/03610730252800166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:06:28Z","timestamp":1770912388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/03610730252800166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1080\/03610730252800166"],"URL":"https:\/\/doi.org\/10.1080\/03610730252800166","relation":{},"ISSN":["0361-073X","1096-4657"],"issn-type":[{"value":"0361-073X","type":"print"},{"value":"1096-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}