{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:22:55Z","timestamp":1782739375557,"version":"3.54.5"},"reference-count":52,"publisher":"Informa UK Limited","issue":"7","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["Discovery grants awarded to JAT and MK"],"award-info":[{"award-number":["Discovery grants awarded to JAT and MK"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomolecular Structure and Dynamics"],"published-print":{"date-parts":[[2016,7,2]]},"DOI":"10.1080\/07391102.2015.1078115","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T15:18:02Z","timestamp":1438355882000},"page":"1455-1469","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":19,"title":["Analysis of the binding mode of laulimalide to microtubules: Establishing a laulimalide\u2013tubulin pharmacophore"],"prefix":"10.1080","volume":"34","author":[{"given":"Cassandra D.M.","family":"Churchill","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, Alberta, Canada T6G 2G2."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Klobukowski","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, Alberta, Canada T6G 2G2."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Tuszynski","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"CIT0001","unstructured":"ADMET predictor version 7.0 [Computational software manual] (2014). Lancaster, California 93534\u20137059. www.simulations-plus.com"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.053"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"31785","DOI":"10.1016\/S0021-9258(18)31764-2","volume":"269","author":"Andreu J. M.","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"CIT0004","first-page":"725","volume":"17","author":"Bennett M. J.","year":"2010","journal-title":"Chemistry & Biology (Oxford, United Kingdom)"},{"key":"CIT0005","first-page":"1269","volume":"12","author":"Buey R. M.","year":"2005","journal-title":"Chemistry & Biology (Oxford, United Kingdom)"},{"key":"CIT0006","volume-title":"Amber14","author":"Case D.","year":"2014"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12595"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12475"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1021\/mp060016h"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3253"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"CIT0012","first-page":"301","volume":"20","author":"Field J.","year":"2013","journal-title":"Chemistry & Biology (Oxford, United Kingdom)"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201007081"},{"key":"CIT0014","unstructured":"Frisch, M. J., Trucks, G. W., Schlegel, H. B., Scuseria, G. E., Robb, M. A., Cheeseman, J. R. (2009).Gaussian 09, revison a.02 ed, Gaussian Inc."},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.12.001"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1124\/mol.66.1.113"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2009.07.122"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1021\/ct200909j"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.027847"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1021\/ci100275a"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.03.026"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1317"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1021\/jp8001614"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1021\/jp902584c"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1021\/ja506385p"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2012.09.022"},{"key":"CIT0029","first-page":"1509","volume":"27","author":"Liu J. K.","year":"2007","journal-title":"Anticancer Research"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.019075"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.11.005"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.10262"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1021\/ct300418h"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1021\/ct600085e"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1021\/mp800043n"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402759101"},{"key":"CIT0037","first-page":"653","volume":"59","author":"Mooberry S. L.","year":"1999","journal-title":"Cancer Research"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1021\/cr940368c"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1021\/ct3010485"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1021\/ci1002894"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80961-7"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1038\/34465"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.03.018"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201307749"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1021\/bi020211b"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1021\/jo00250a052"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90098-5"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1021\/ct400314y"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.5.2031"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1021\/ol035339f"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1021\/ol061619u"}],"container-title":["Journal of Biomolecular Structure and Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07391102.2015.1078115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T20:09:09Z","timestamp":1652990949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07391102.2015.1078115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7,2]]}},"alternative-id":["10.1080\/07391102.2015.1078115"],"URL":"https:\/\/doi.org\/10.1080\/07391102.2015.1078115","relation":{},"ISSN":["0739-1102","1538-0254"],"issn-type":[{"value":"0739-1102","type":"print"},{"value":"1538-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}