{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:56:04Z","timestamp":1794272164866,"version":"4.9.0"},"reference-count":77,"publisher":"Informa UK Limited","issue":"21","funder":[{"name":"Funda??o Cearense de Apoio ao Desenvolvimento Cient?fico e Tecnol?gico"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomolecular Structure and Dynamics"],"published-print":{"date-parts":[[2023,12,29]]},"DOI":"10.1080\/07391102.2023.2167116","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T08:55:12Z","timestamp":1673859312000},"page":"12426-12444","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":22,"title":["GABA\n            <sub>A<\/sub>\n            and serotonergic receptors participation in anxiolytic effect of chalcones in adult zebrafish"],"prefix":"10.1080","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-6707","authenticated-orcid":false,"given":"Francisco Rog\u00eanio Silva","family":"Mendes","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri, Crato, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-1644","authenticated-orcid":false,"given":"Antonio Wlisses","family":"da Silva","sequence":"additional","affiliation":[{"name":"Graduate Program of Biotechnology, State University of Ceara, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-8109","authenticated-orcid":false,"given":"Maria Kueirislene Am\u00e2ncio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Graduate Program in Natural Sciences, State University of Ceara, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-5196","authenticated-orcid":false,"given":"Emanuela de Lima","family":"Rebou\u00e7as","sequence":"additional","affiliation":[{"name":"Graduate Program of Biotechnology, State University of Ceara, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4621-7355","authenticated-orcid":false,"given":"Italo","family":"Moura Barbosa","sequence":"additional","affiliation":[{"name":"Graduate Program in Natural Sciences, State University of Ceara, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0929-4565","authenticated-orcid":false,"given":"Matheus Nunes","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Limoeiro do Norte, State University of Ceara, Limoeiro do Norte, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walber","family":"Henrique Ferreira Ribeiro","sequence":"additional","affiliation":[{"name":"Chemistry Course, State University of Vale do Acara\u00fa, Sobral, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-9683","authenticated-orcid":false,"given":"Ramon R\u00f3seo Paula Pessoa Bezerra de","family":"Menezes","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-7935","authenticated-orcid":false,"given":"Emanuel Paula","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-8574","authenticated-orcid":false,"given":"Emanuelle Machado","family":"Marinho","sequence":"additional","affiliation":[{"name":"Department of Analytical and Physical Chemistry, Federal University of Ceara, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-2220","authenticated-orcid":false,"given":"M\u00e1rcia Machado","family":"Marinho","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri, Crato, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-1839","authenticated-orcid":false,"given":"Paulo Nogueira","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Chemistry Course, State University of Vale do Acara\u00fa, Sobral, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9632-5464","authenticated-orcid":false,"given":"Jane Eire Silva Alencar","family":"de Menezes","sequence":"additional","affiliation":[{"name":"Graduate Program in Natural Sciences, State University of Ceara, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-8775","authenticated-orcid":false,"given":"Emmanuel Silva","family":"Marinho","sequence":"additional","affiliation":[{"name":"Graduate Program in Natural Sciences, State University of Ceara, Fortaleza, Cear\u00e1, Brazil"},{"name":"Department of Chemistry, Limoeiro do Norte, State University of Ceara, Limoeiro do Norte, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-164X","authenticated-orcid":false,"given":"H\u00e9lcio Silva","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri, Crato, Cear\u00e1, Brazil"},{"name":"Graduate Program of Biotechnology, State University of Ceara, Fortaleza, Cear\u00e1, Brazil"},{"name":"Graduate Program in Natural Sciences, State University of Ceara, Fortaleza, Cear\u00e1, Brazil"},{"name":"Chemistry Course, State University of Vale do Acara\u00fa, Sobral, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2012.10.014"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibror.2019.09.085"},{"key":"e_1_3_3_4_1","unstructured":"Arellano-Aguiar O. Solis-Angeles S. Serrano-Garc\u00eda L. Morales-Sierra E. Mendez-Serrano A. Montero-Montoya R. (2015). Use of the Zebrafish Embryo Toxicity Test for Risk Assessment Purpose: Case Study. Fisheriessciences.com 9 (4) 052\u2013062."},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104967"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa161"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11142-8"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104892"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.06.012"},{"key":"e_1_3_3_10_1","volume-title":"Discovery studio modeling environment, release 2017, San Diego","author":"Biovia D. S.","year":"2016","unstructured":"Biovia, D. S. (2016). Discovery studio modeling environment, release 2017, San Diego. Dassault Syst\u00e8mes."},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.02.019"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actpha.2019.09.027"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017597"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0071-0"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.12.007"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30024-4"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.09.026"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13311-5"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470015902.a0027709"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ecsoc-3-01775"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2021.1935322"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-021-02116-z"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.21577\/1984-6835.20200057"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.25072"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/12040896"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.17"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2014.977819"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-184"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physa.2019.122210"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.107881"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.03.040"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.03.129"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.04.021"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm701122q"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.10379"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00610-7"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.128637"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103772"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/2394-2002.139626"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6\u2009<\u2009490::AID-JCC1\u2009>\u20093.0.CO;2-P"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579412000041"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-4-17"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01376"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108100322"},{"key":"e_1_3_3_45_1","first-page":"2","article-title":"Using AutoDock 4 and AutoDock Vina with AutoDockTools: A tutorial","author":"Huey R.","year":"2012","unstructured":"Huey, R., Morris, G. M., & Forli, S. (2012). Using AutoDock 4 and AutoDock Vina with AutoDockTools: A tutorial. The Scripps Research Institute Molecular, 2-28.","journal-title":"The Scripps Research Institute Molecular"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.07.071"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.08.045"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2021.139022"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2012.01380.x"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2004.11.007"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.2147\/jep.s23105"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104365"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0832-5"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.01.031"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.05.004"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(99)00065-6"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109348161"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105053"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0223-5234(02)01387-9"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty419"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.592654"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.2147\/AABC.S63749"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105303"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.15406\/japlr.2021.10.00384"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.02.011"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.07.037"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.11.035"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040958"},{"key":"e_1_3_3_76_1","volume-title":"Depression and other common mental disorders","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. (2017). Depression and other common mental disorders. Global Health Estimates."},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.12.007"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci800084x"}],"container-title":["Journal of Biomolecular Structure and Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07391102.2023.2167116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T12:34:10Z","timestamp":1701693250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07391102.2023.2167116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,16]]},"references-count":77,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,12,29]]}},"alternative-id":["10.1080\/07391102.2023.2167116"],"URL":"https:\/\/doi.org\/10.1080\/07391102.2023.2167116","relation":{},"ISSN":["0739-1102","1538-0254"],"issn-type":[{"value":"0739-1102","type":"print"},{"value":"1538-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}