{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T09:07:48Z","timestamp":1794388068546,"version":"4.9.0"},"reference-count":107,"publisher":"Informa UK Limited","issue":"19","funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["DST-SERB-EMR: EMR\/2017\/005381"],"award-info":[{"award-number":["DST-SERB-EMR: EMR\/2017\/005381"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/BI\/25\/063\/2012"],"award-info":[{"award-number":["BT\/BI\/25\/063\/2012"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Science and Technology, India-funded Infrastructure in Higher Educational Institutions","award":["SR\/FST\/LSI-616\/2014"],"award-info":[{"award-number":["SR\/FST\/LSI-616\/2014"]}]},{"DOI":"10.13039\/100015747","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F.3-19\/2018\/DRS-III(SAP-II)"],"award-info":[{"award-number":["F.3-19\/2018\/DRS-III(SAP-II)"]}],"id":[{"id":"10.13039\/100015747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomolecular Structure and Dynamics"],"published-print":{"date-parts":[[2024,12,2]]},"DOI":"10.1080\/07391102.2023.2257322","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T07:51:39Z","timestamp":1695282699000},"page":"10521-10538","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Metabolic deregulation associated with aging modulates protein aggregation in the yeast model of Huntington\u2019s disease"],"prefix":"10.1080","volume":"42","author":[{"given":"Sai Sanwid","family":"Pradhan","sequence":"first","affiliation":[{"name":"Disease Biology Lab, Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, Anantapur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Swaroop","family":"R.","sequence":"additional","affiliation":[{"name":"Disease Biology Lab, Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, Anantapur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Phalguna","family":"Kanikaram","sequence":"additional","affiliation":[{"name":"Disease Biology Lab, Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, Anantapur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Datta Darshan","family":"V.M.","sequence":"additional","affiliation":[{"name":"Disease Biology Lab, Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, Anantapur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Pargaonkar","sequence":"additional","affiliation":[{"name":"Application Division, Agilent Technologies Ltd., Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Babu","family":"Dandamudi","sequence":"additional","affiliation":[{"name":"Phenomenex India, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-5905","authenticated-orcid":false,"given":"Venketesh","family":"Sivaramakrishnan","sequence":"additional","affiliation":[{"name":"Disease Biology Lab, Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, Anantapur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.010926"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00626-7"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2017.09.005"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1085"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-398"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10629"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2017.03.009"},{"issue":"2","key":"e_1_3_4_9_1","first-page":"288","article-title":"Pyroglutamic acid: Throwing light on a lightly studied metabolite","volume":"102","author":"Bachhawat A.","year":"2011","unstructured":"Bachhawat, A. (2011). Pyroglutamic acid: Throwing light on a lightly studied metabolite. Current Science, 102(2), 288\u2013297.","journal-title":"Current Science"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1686"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.0c00335"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94607-5"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2009.11.003"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074367"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315392"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182276099"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044785"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(97)88136-6"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02550-7"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02640-8"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47582-x"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604547103"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1027-z"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-387"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200005)15:3<552::AID-MDS1020>3.0.CO;2-P"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21559"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007476"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2018-0009"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1728096"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0244-z"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2450-5"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.003"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.036"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi802065j"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.2310\/7010.2006.00055"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.6b00049"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.04.012"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm80"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26001"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13285"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40186-5"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00350.x"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1357"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1259472"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12120.1"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.192138"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr900734g"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30892-6"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1589"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-160205"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3469790"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.576592"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.09.008"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-007-0085-4"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.759729"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.05.035"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200112104"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg295"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062039"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa115"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75197-0"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113788"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v6.i6.301"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06612.x"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05356.x"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2018.0101"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00068"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.05.008"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(02)03102-5"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(00)02082-5"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-023-03525-y"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049492"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89137-z"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155807"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.07.010"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091228"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-40"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.214"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2005.05.011"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2022.2090441"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608264113"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80514-0"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-120044"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12253"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fow102"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.06.008"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00066-15"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43030"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.052"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-393"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.05.014"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2022.2115555"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03070.x"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-022-03401-1"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.10.029"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.101527"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.329528"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr050244o"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb300440x"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2017-0075"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/434289"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00811-15"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00098"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010196"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.509158"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308679101"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00056-3"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.131"}],"container-title":["Journal of Biomolecular Structure and Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07391102.2023.2257322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T09:18:01Z","timestamp":1730452681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07391102.2023.2257322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":107,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,12,2]]}},"alternative-id":["10.1080\/07391102.2023.2257322"],"URL":"https:\/\/doi.org\/10.1080\/07391102.2023.2257322","relation":{},"ISSN":["0739-1102","1538-0254"],"issn-type":[{"value":"0739-1102","type":"print"},{"value":"1538-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}