{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:54:34Z","timestamp":1774378474657,"version":"3.50.1"},"reference-count":81,"publisher":"Informa UK Limited","issue":"17","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomolecular Structure and Dynamics"],"published-print":{"date-parts":[[2025,11,22]]},"DOI":"10.1080\/07391102.2024.2438357","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T01:01:03Z","timestamp":1733965263000},"page":"10238-10251","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Elucidating the mechanisms of a herbal compound fumarine and its modulation on the estrogen receptor 1"],"prefix":"10.1080","volume":"43","author":[{"given":"Sanghyun","family":"Lee","sequence":"first","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University","place":["Bundoora, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Rann","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University","place":["Bundoora, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanife","family":"Mehmet","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University","place":["Bundoora, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Wei Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University","place":["Bundoora, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3569-2951","authenticated-orcid":false,"given":"Andrew","family":"Hung","sequence":"additional","affiliation":[{"name":"School of Science, RMIT University","place":["Melbourne, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2002.0090s1030.x"},{"key":"e_1_3_3_3_1","first-page":"19","volume-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","author":"Abraham M. J.","year":"2015","unstructured":"Abraham, M. J., Murtola, T., P\u00e1ll, S., Smith, J. C., Hess, B., & Lindahl, E.(2015). GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers (vol. 1\u20132, pp. 19\u201325). Peer-Reviewed Journal."},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2023.101739"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0005188"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.464913"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.448118"},{"key":"e_1_3_3_8_1","unstructured":"BIOVIA Dassault Syst\u00e8mes. (2017). Discovery Studio Visualizer. San Diego: Dassault Syst\u00e8mes."},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21287"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2408420"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1133"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi061656t"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/136140968700100305"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-016-0804-z"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112270"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2019.1574605"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2269-7_19"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-658-0_11"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp043511"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362719"},{"issue":"4","key":"e_1_3_3_24_1","first-page":"e111","article-title":"Cardioembolic stroke secondary to an aortic valve fibroelastoma: An increasingly recognized rare cause of stroke","volume":"52","author":"Esteban-Luci\u00e1 L.","year":"2021","unstructured":"Esteban-Luci\u00e1, L., Batista, S. D. F., Mayor, A. M., & Garc\u00eda, M. C. (2021). Cardioembolic stroke secondary to an aortic valve fibroelastoma: An increasingly recognized rare cause of stroke. Journal of the American Heart Association, 52(4), e111\u2013e114.","journal-title":"Journal of the American Heart Association"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1032936"},{"key":"e_1_3_3_26_1","unstructured":"Genomics B. E. (2022). Calculate and draw custom Venn diagrams [cited 2022 September 20]. https:\/\/bioinformatics.psb.ugent.be\/webtools\/Venn\/"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0749-3797(03)00206-x"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2363262"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2012.82"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201300024"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004597"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.3.CO;2-L"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci100275a"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010215"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2015.0202"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00159"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-016-0142-6"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp960669l"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.28.10.1871"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci500020m"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1103\/physrevb.37.785"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/2515690X221082989"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105568"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(02)01627-8"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203794"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019137"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0098-3004(93)90090-R"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000141863.52691.44"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2016.08.009"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0018516"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23081899"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed5004228"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00104"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.83084"},{"key":"e_1_3_3_57_1","unstructured":"PubChem. (2024). Experimental IR spectra [cited 2024 March 17]. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Protopine#section=Related-Records"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221331"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2022.120234"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283364"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100096a001"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1003"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1049"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.08.396"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13371"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1139\/p80-159"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2020.0007"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.24467"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00055"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03826-4"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.871481"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"e_1_3_3_76_1","first-page":"339","volume-title":", UK ISBN 9781849736701; 2708 pages. April 2013, $150 with 1-year free access to The Merck Index online, drug development research","author":"Williams M.","year":"2013","unstructured":"Williams, M. (2013). The Merck Index: An encyclopedia of chemicals, drugs, and biologicals. In M. J. O\u2019Neil (Ed.), UK ISBN 9781849736701; 2708 pages. April 2013, $150 with 1-year free access to The Merck Index online, drug development research (15th Edition, vol. 74, issnum 5, pp. 339\u2013339. Royal Society of Chemistry."},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00075.x"},{"issue":"8","key":"e_1_3_3_79_1","first-page":"528","article-title":"Diagnosis of acute stroke","volume":"91","author":"Yew K. S.","year":"2015","unstructured":"Yew, K. S., & Cheng, E. M. (2015). Diagnosis of acute stroke. American Family Physician, 91(8), 528\u2013536.","journal-title":"American Family Physician,"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/00268976.2023.2231571"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25010015"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21816"}],"updated-by":[{"DOI":"10.1080\/07391102.2024.2444746","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000}}],"container-title":["Journal of Biomolecular Structure and Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07391102.2024.2438357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T15:06:24Z","timestamp":1764860784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07391102.2024.2438357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":81,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,11,22]]}},"alternative-id":["10.1080\/07391102.2024.2438357"],"URL":"https:\/\/doi.org\/10.1080\/07391102.2024.2438357","relation":{},"ISSN":["0739-1102","1538-0254"],"issn-type":[{"value":"0739-1102","type":"print"},{"value":"1538-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}