{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:20Z","timestamp":1780272020901,"version":"3.54.0"},"reference-count":31,"publisher":"Informa UK Limited","issue":"9","funder":[{"name":"Pakistan Science foundation","award":["PSF-257"],"award-info":[{"award-number":["PSF-257"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biomolecular Structure and Dynamics"],"published-print":{"date-parts":[[2026,6,13]]},"DOI":"10.1080\/07391102.2025.2543358","type":"journal-article","created":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T15:28:29Z","timestamp":1754839709000},"page":"4330-4348","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Mutation-specific structural changes in BRAF: understanding dimerization and drug binding for targeted therapy"],"prefix":"10.1080","volume":"44","author":[{"given":"Minjie","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]},{"name":"Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Zafar","sequence":"additional","affiliation":[{"name":"Evolutionary Biology Lab, CABB, University of Agriculture Faisalabad","place":["Faisalabad Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Serfraz","sequence":"additional","affiliation":[{"name":"Evolutionary Biology Lab, CABB, University of Agriculture Faisalabad","place":["Faisalabad Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Chongqing General Hospital","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,8,10]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2020.105660"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2019.1705186"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1107\/97809553602060000864"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065000"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011536"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210421"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2006.12.005"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.29.18623"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.8.7768349"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08833"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23354"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00780-4"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.024"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.169"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.06.007"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540130805"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3781"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08314"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210422"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky300"},{"key":"e_1_3_5_26_1","unstructured":"Schr\u00f6dinger Release 2025-2. (2025). Prime Schr\u00f6dinger LLC New York NY."},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00645"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21367"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14126"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(04)00215-6"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1443"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.08.001"}],"container-title":["Journal of Biomolecular Structure and Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07391102.2025.2543358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T23:01:05Z","timestamp":1780268465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07391102.2025.2543358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,10]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,6,13]]}},"alternative-id":["10.1080\/07391102.2025.2543358"],"URL":"https:\/\/doi.org\/10.1080\/07391102.2025.2543358","relation":{},"ISSN":["0739-1102","1538-0254"],"issn-type":[{"value":"0739-1102","type":"print"},{"value":"1538-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbsd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}