{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:27:50Z","timestamp":1788791270179,"version":"build-2803163510"},"reference-count":135,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Chronobiology International"],"DOI":"10.1080\/07420528.2026.2723197","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:37:06Z","timestamp":1788788226000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["DRP-1 and circadian rhythms: deciphering their impact on PCOS"],"prefix":"10.1080","author":[{"given":"Aparna Eledath","family":"Kolasseri","sequence":"first","affiliation":[{"name":"Vellore Institute of Technology","place":["Vellore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrani Paramasivan","family":"Latha Laxmi","sequence":"additional","affiliation":[{"name":"Vellore Institute of Technology","place":["Vellore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaraman","family":"Jayanthi","sequence":"additional","affiliation":[{"name":"Vellore Institute of Technology","place":["Vellore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-6308","authenticated-orcid":false,"given":"Ramasamy","family":"Tamizhselvi","sequence":"additional","affiliation":[{"name":"Vellore Institute of Technology","place":["Vellore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"48","key":"e_1_3_4_2_1","doi-asserted-by":"crossref","first-page":"45208","DOI":"10.1021\/acsomega.3c06547","article-title":"DRP1: at the crossroads of dysregulated mitochondrial dynamics and altered cell signaling in cancer cells","volume":"8","author":"Adhikary A","year":"2023","unstructured":"Adhikary A, Mukherjee A, Banerjee R, Nagotu S. 2023. DRP1: at the crossroads of dysregulated mitochondrial dynamics and altered cell signaling in cancer cells. ACS Omega. 8(48):45208\u201345223.","journal-title":"ACS Omega"},{"issue":"3","key":"e_1_3_4_3_1","doi-asserted-by":"crossref","first-page":"C835","DOI":"10.1152\/ajpcell.00205.2022","article-title":"Role of androgens and androgen receptor in control of mitochondrial function","volume":"323","author":"Ahmad I","year":"2022","unstructured":"Ahmad I, Newell-Fugate AE. 2022. Role of androgens and androgen receptor in control of mitochondrial function. Am J Physiol-Cell Physiol. 323(3):C835\u201346.","journal-title":"Am J Physiol-Cell Physiol"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-11010-3"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-128"},{"issue":"7206","key":"e_1_3_4_6_1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature07181","article-title":"UCP2 mediates ghrelin\u2019s action on NPY\/AgRP neurons by lowering free radicals","volume":"454","author":"Andrews ZB","year":"2008","unstructured":"Andrews ZB et al. 2008. UCP2 mediates ghrelin\u2019s action on NPY\/AgRP neurons by lowering free radicals. Nature. 454(7206):846\u2013851.","journal-title":"Nature"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.06.009"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0178"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.57"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-022-02739-y"},{"issue":"11","key":"e_1_3_4_11_1","doi-asserted-by":"crossref","first-page":"e21237","DOI":"10.1016\/j.heliyon.2023.e21237","article-title":"Melatonin as a promising therapeutic intervention for restoring ovarian function in letrozole-induced polycystic ovary syndrome rats","volume":"9","author":"Basheer M","year":"2023","unstructured":"Basheer M et al. 2023. Melatonin as a promising therapeutic intervention for restoring ovarian function in letrozole-induced polycystic ovary syndrome rats. Heliyon. 9(11):e21237.","journal-title":"Heliyon"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10081851"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.010"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218"},{"issue":"3","key":"e_1_3_4_15_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41419-023-05721-3","article-title":"Rab32 promotes glioblastoma migration and invasion via regulation of ERK\/Drp1-mediated mitochondrial fission","volume":"14","author":"Chen P","year":"2023","unstructured":"Chen P et al. 2023. Rab32 promotes glioblastoma migration and invasion via regulation of ERK\/Drp1-mediated mitochondrial fission. Cell Death Dis. 14(3):198.","journal-title":"Cell Death Dis"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-025-05609-9"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01547-9"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.70233"},{"issue":"8","key":"e_1_3_4_19_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1158\/1541-7786.MCR-10-0445","article-title":"Novel role of androgens in mitochondrial fission and apoptosis","volume":"9","author":"Choudhary V","year":"2011","unstructured":"Choudhary V et al. 2011. Novel role of androgens in mitochondrial fission and apoptosis. Mol Cancer Res. 9(8):1067\u20131077.","journal-title":"Mol Cancer Res"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.11012"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.954186"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.12.002"},{"issue":"2","key":"e_1_3_4_23_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/2096-2924.320884","article-title":"Long-term androgen-induced nonalcoholic fatty liver disease in a polycystic ovary syndrome mouse model is related to mitochondrial dysfunction","volume":"5","author":"Cui P","year":"2021","unstructured":"Cui P et al. 2021. Long-term androgen-induced nonalcoholic fatty liver disease in a polycystic ovary syndrome mouse model is related to mitochondrial dysfunction. Reprod Dev Med. 5(2):71\u201380.","journal-title":"Reprod Dev Med"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-022-01333-w"},{"issue":"1","key":"e_1_3_4_25_1","first-page":"56","article-title":"The influence of melatonin supplementation on in vitro culture of murine embryos from polycystic ovary syndrome experimental models","volume":"30","author":"de Oliveira Pinheiro M","year":"2026","unstructured":"de Oliveira Pinheiro M et al. 2026. The influence of melatonin supplementation on in vitro culture of murine embryos from polycystic ovary syndrome experimental models. JBRA Assisted Reproduction. 30(1):56.","journal-title":"JBRA Assisted Reproduction"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.11165"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1415455"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098479"},{"issue":"1","key":"e_1_3_4_29_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cell.2013.09.004","article-title":"Mitochondrial dynamics controlled by mitofusins regulate agrp neuronal activity and diet-induced obesity","volume":"155","author":"Dietrich MO","year":"2013","unstructured":"Dietrich MO, Liu ZW, Horvath TL. 2013. Mitochondrial dynamics controlled by mitofusins regulate agrp neuronal activity and diet-induced obesity. Cell. 155(1):188\u2013199.","journal-title":"Cell"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S511467"},{"issue":"1","key":"e_1_3_4_31_1","first-page":"316","article-title":"Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR","volume":"43","author":"Ding Y","year":"2019","unstructured":"Ding Y et al. 2019. Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR. Int J Mol Med. 43(1):316\u2013324.","journal-title":"Int J Mol Med"},{"issue":"1","key":"e_1_3_4_32_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s12967-023-04200-9","article-title":"The role of mitochondria in the resistance of melanoma to PD-1 inhibitors","volume":"21","author":"Du F","year":"2023","unstructured":"Du F et al. 2023. The role of mitochondria in the resistance of melanoma to PD-1 inhibitors. J Transl Med. 21(1):345.","journal-title":"J Transl Med"},{"issue":"4","key":"e_1_3_4_33_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41419-020-2461-9","article-title":"Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways","volume":"11","author":"Duan C","year":"2020","unstructured":"Duan C et al. 2020. Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways. Cell Death Dis. 11(4):251.","journal-title":"Cell Death Dis"},{"issue":"5","key":"e_1_3_4_34_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale HF","year":"2018","unstructured":"Escobar-Morreale HF. 2018. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 14(5):270\u2013284.","journal-title":"Nat Rev Endocrinol"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5652586"},{"issue":"2","key":"e_1_3_4_36_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrm3266","article-title":"Dynamin, a membrane-remodelling GTPase","volume":"13","author":"Ferguson SM","year":"2012","unstructured":"Ferguson SM, De Camilli P. 2012. Dynamin, a membrane-remodelling GTPase. Nat Rev Mol Cell Biol. 13(2):75\u201388.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S127475"},{"key":"e_1_3_4_38_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-4614-3573-0_2","volume-title":"Mitochondrial Oxidative PhosphorylationNuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology","author":"Ferree A","year":"2012","unstructured":"Ferree A, Shirihai O. 2012. Mitochondrial dynamics: the intersection of form and function. Mitochondrial oxidative phosphorylation: Nuclear-encoded genes, enzyme regulation, and pathophysiology. In: Bernhard K, editor. Mitochondrial Oxidative PhosphorylationNuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology. Springer; pp 13\u201340."},{"issue":"3","key":"e_1_3_4_39_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122308","article-title":"Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration","volume":"10","author":"Ferreira-da-Silva A","year":"2015","unstructured":"Ferreira-da-Silva A et al. 2015. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. PLoS One. 10(3), p.e0122308.","journal-title":"PLoS One"},{"issue":"10","key":"e_1_3_4_40_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/tra.12676","article-title":"The structural biology of the dynamin-related proteins: new insights into a diverse, multitalented family","volume":"20","author":"Ford MGJ","year":"2019","unstructured":"Ford MGJ, Chappie JS. 2019. The structural biology of the dynamin-related proteins: new insights into a diverse, multitalented family. Traffic. 20(10):717\u2013740.","journal-title":"Traffic"},{"issue":"5","key":"e_1_3_4_41_1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/emmm.201303782","article-title":"Mitochondrial response to nutrient availability and its role in metabolic disease","volume":"6","author":"Gao AW","year":"2014","unstructured":"Gao AW, Cant\u00f3 C, Houtkooper RH. 2014. Mitochondrial response to nutrient availability and its role in metabolic disease. EMBO Mol Med. 6(5):580\u2013589.","journal-title":"EMBO Mol Med"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107537"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18753-6"},{"issue":"2","key":"e_1_3_4_44_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41419-024-06511-1","article-title":"Ruxolitinib induces apoptosis and pyroptosis of anaplastic thyroid cancer via the transcriptional inhibition of DRP1-mediated mitochondrial fission","volume":"15","author":"Guo YW","year":"2024","unstructured":"Guo YW et al. 2024. Ruxolitinib induces apoptosis and pyroptosis of anaplastic thyroid cancer via the transcriptional inhibition of DRP1-mediated mitochondrial fission. Cell Death Disease. 15(2):125.","journal-title":"Cell Death Disease"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0949-5"},{"issue":"9371","key":"e_1_3_4_46_1","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/S0140-6736(03)13409-5","article-title":"Polycystic ovary syndrome and endometrial carcinoma","volume":"361","author":"Hardiman P","year":"2003","unstructured":"Hardiman P, Pillay OS, Atiomo W. 2003. Polycystic ovary syndrome and endometrial carcinoma. Lancet. 361(9371):1810\u20131812.","journal-title":"Lancet"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal033"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2324-19.2020"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2025.112606"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xagr.2025.100479"},{"issue":"1","key":"e_1_3_4_51_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/bbrc.1998.9275","article-title":"Circadian oscillation ofBMAL1, a partner of a mammalian clock GeneClock, in rat suprachiasmatic nucleus","volume":"250","author":"Honma S","year":"1998","unstructured":"Honma S et al. 1998. Circadian oscillation ofBMAL1, a partner of a mammalian clock GeneClock, in rat suprachiasmatic nucleus. Biochem Bioph Res Co. 250(1):83\u201387.","journal-title":"Biochem Bioph Res Co"},{"issue":"5","key":"e_1_3_4_52_1","first-page":"E794","article-title":"Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production","volume":"316","author":"Hu M","year":"2019","unstructured":"Hu M et al. 2019. Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production. Am J Physiol-Endoc M. 316(5):E794\u2013809.","journal-title":"Am J Physiol-Endoc M"},{"issue":"13","key":"e_1_3_4_53_1","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1002\/1878-0261.13212","article-title":"DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1\/MMP12 axis","volume":"16","author":"Huang TL","year":"2022","unstructured":"Huang TL et al. 2022. DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1\/MMP12 axis. Mol Oncol. 16(13):2585\u20132606.","journal-title":"Mol Oncol"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01054-14"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.962154"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1142512"},{"issue":"8","key":"e_1_3_4_57_1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/humrep\/deac139","article-title":"Derailed peripheral circadian genes in polycystic ovary syndrome patients alters peripheral conversion of androgens synthesis","volume":"37","author":"Johnson BS","year":"2022","unstructured":"Johnson BS et al. 2022. Derailed peripheral circadian genes in polycystic ovary syndrome patients alters peripheral conversion of androgens synthesis. Hum Reproduction. 37(8):1835\u20131855.","journal-title":"Hum Reproduction"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.04.009"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1530\/endoabs.110.P1030"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.06.192"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.199562"},{"issue":"4","key":"e_1_3_4_62_1","doi-asserted-by":"crossref","first-page":"e258","DOI":"10.1212\/NXG.0000000000000258","article-title":"De Novo DNM1L mutation associated with mitochondrial epilepsy syndrome with fever sensitivity","volume":"4","author":"Ladds E","year":"2018","unstructured":"Ladds E et al. 2018. De Novo DNM1L mutation associated with mitochondrial epilepsy syndrome with fever sensitivity. Neurol Genet. 4(4):e258.","journal-title":"Neurol Genet"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09430-8"},{"issue":"6","key":"e_1_3_4_64_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/cells13060523","article-title":"Steroidogenesis upregulation through mitochondria-associated endoplasmic reticulum Membranes and mitochondrial dynamics in rat testes: the role of D-Aspartate","volume":"13","author":"Latino D","year":"2024","unstructured":"Latino D et al. 2024. Steroidogenesis upregulation through mitochondria-associated endoplasmic reticulum Membranes and mitochondrial dynamics in rat testes: the role of D-Aspartate. Cells. 13(6):523.","journal-title":"Cells"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00429"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.12.017"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107250"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-022-01661-w"},{"key":"e_1_3_4_69_1","doi-asserted-by":"crossref","first-page":"153958","DOI":"10.1016\/j.tox.2024.153958","article-title":"Dihydrotestosterone induces reactive oxygen species accumulation and mitochondrial fission leading to apoptosis of granulosa cells","volume":"509","author":"Li X","year":"2024","unstructured":"Li X et al. 2024. Dihydrotestosterone induces reactive oxygen species accumulation and mitochondrial fission leading to apoptosis of granulosa cells. Toxicology. 509:153958.","journal-title":"Toxicology"},{"issue":"1","key":"e_1_3_4_70_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EC-23-0343","article-title":"Mfn2 regulates mitochondria-associated ER membranes to affect PCOS oocyte development","volume":"13","author":"Liao X","year":"2023","unstructured":"Liao X et al. 2023. Mfn2 regulates mitochondria-associated ER membranes to affect PCOS oocyte development. Endocr Connect. 13(1):1\u201310.","journal-title":"Endocr Connect"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2008"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines7010005"},{"issue":"4","key":"e_1_3_4_73_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.201511036","article-title":"Metabolic regulation of mitochondrial dynamics","volume":"212","author":"Mishra P","year":"2016","unstructured":"Mishra P, Chan DC. 2016. Metabolic regulation of mitochondrial dynamics. J Cell Biol. 212(4):379\u2013387.","journal-title":"J Cell Biol"},{"issue":"4","key":"e_1_3_4_74_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1083\/jcb.201110058","article-title":"DRP1-dependent mitochondrial fission initiates follicle cell differentiation during drosophila oogenesis","volume":"197","author":"Mitra K","year":"2012","unstructured":"Mitra K, Rikhy R, Lilly M, Lippincott-Schwartz J. 2012. DRP1-dependent mitochondrial fission initiates follicle cell differentiation during drosophila oogenesis. J Cell Biol. 197(4):487\u2013497.","journal-title":"J Cell Biol"},{"issue":"7","key":"e_1_3_4_75_1","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3390\/ijms19072076","article-title":"Mitochondrial dysfunctions in type I endometrial carcinoma: exploring their role in oncogenesis and tumor progression","volume":"19","author":"Musicco C","year":"2018","unstructured":"Musicco C et al. 2018. Mitochondrial dysfunctions in type I endometrial carcinoma: exploring their role in oncogenesis and tumor progression. Int J Mol Sci. 19(7):2076.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-00946-w"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.035"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1068045"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(99)00242-7"},{"issue":"6","key":"e_1_3_4_80_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/s43018-023-00563-6","article-title":"Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases","volume":"4","author":"Parida PK","year":"2023","unstructured":"Parida PK et al. 2023. Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases. Nat Cancer. 4(6):893\u2013907.","journal-title":"Nat Cancer"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00029"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.12717\/DR.2022.26.2.71"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105011"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.12.4403"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902958R"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03818-6"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2013.823160"},{"issue":"9","key":"e_1_3_4_88_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1160\/TH14-09-0797","article-title":"Metformin reduces hyper-reactivity of platelets from patients with polycystic ovary syndrome by improving mitochondrial integrity","volume":"114","author":"Randriamboavonjy V","year":"2015","unstructured":"Randriamboavonjy V et al. 2015. Metformin reduces hyper-reactivity of platelets from patients with polycystic ovary syndrome by improving mitochondrial integrity. Thromb Haemost. 114(9):569\u2013578.","journal-title":"Thromb Haemost"},{"issue":"1","key":"e_1_3_4_89_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12929-022-00846-7","article-title":"The A\u2019-helix of CYP11A1 remodels mitochondrial cristae","volume":"29","author":"Rosal KG","year":"2022","unstructured":"Rosal KG, Chen WY, Chung BC. 2022. The A\u2019-helix of CYP11A1 remodels mitochondrial cristae. J Biomed Sci. 29(1):61.","journal-title":"J Biomed Sci"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"issue":"10","key":"e_1_3_4_91_1","first-page":"1","article-title":"Androgen-mediated perturbation of the hepatic circadian System through epigenetic modulation promotes NAFLD in PCOS mice","volume":"163","author":"Roy S","year":"2022","unstructured":"Roy S et al. 2022. Androgen-mediated perturbation of the hepatic circadian System through epigenetic modulation promotes NAFLD in PCOS mice. Endocrinology. 163(10):1\u201316.","journal-title":"Endocrinology"},{"issue":"1","key":"e_1_3_4_92_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41598-020-57672-w","article-title":"Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome","volume":"10","author":"Salehi R","year":"2020","unstructured":"Salehi R et al. 2020. Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome. Sci Rep. 10(1):1021.","journal-title":"Sci Rep"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00452"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.01.011"},{"issue":"1","key":"e_1_3_4_95_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0748730414554222","article-title":"Circadian clock function in the mammalian ovary","volume":"30","author":"Sellix MT","year":"2015","unstructured":"Sellix MT. 2015. Circadian clock function in the mammalian ovary. J Biol Rhythms. 30(1):7\u201319.","journal-title":"J Biol Rhythms"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.06.002"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111818"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1097\/RD9.0000000000000051"},{"key":"e_1_3_4_99_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/259345","article-title":"Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder","volume":"2010","author":"Shechter A","year":"2010","unstructured":"Shechter A, Db B. 2010. Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder. Int J Endocrinol. 2010:1\u201317.","journal-title":"Int J Endocrinol"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02385"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156251"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.789008"},{"key":"e_1_3_4_103_1","doi-asserted-by":"crossref","first-page":"100037","DOI":"10.1016\/j.arres.2022.100037","article-title":"Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases","volume":"5","author":"Sulaimon LA","year":"2022","unstructured":"Sulaimon LA et al. 2022. Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases. Adv Redox Res. 5:100037.","journal-title":"Adv Redox Res"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.1.5389"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3639302"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.7.15695"},{"issue":"37","key":"e_1_3_4_107_1","doi-asserted-by":"crossref","first-page":"60021","DOI":"10.18632\/oncotarget.11047","article-title":"Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients","volume":"7","author":"Tanwar DK","year":"2016","unstructured":"Tanwar DK et al. 2016. Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients. Oncotarget. 7(37):60021\u201360037.","journal-title":"Oncotarget"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0925"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136233"},{"issue":"59","key":"e_1_3_4_110_1","doi-asserted-by":"crossref","first-page":"99825","DOI":"10.18632\/oncotarget.21076","article-title":"Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2\/M arrest","volume":"8","author":"Tsuyoshi H","year":"2017","unstructured":"Tsuyoshi H et al. 2017. Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2\/M arrest. Oncotarget. 8(59):99825\u201399840.","journal-title":"Oncotarget"},{"issue":"20","key":"e_1_3_4_111_1","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.cub.2014.08.060","article-title":"Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles","volume":"24","author":"Udagawa O","year":"2014","unstructured":"Udagawa O et al. 2014. Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles. Curr Biol. 24(20):2451\u20132458.","journal-title":"Curr Biol"},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.08.1425"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.848214"},{"issue":"10","key":"e_1_3_4_114_1","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.3390\/cells9102323","article-title":"Clock-controlled mitochondrial dynamics correlates with cyclic pregnenolone synthesis","volume":"9","author":"Witzig M","year":"2020","unstructured":"Witzig M et al. 2020. Clock-controlled mitochondrial dynamics correlates with cyclic pregnenolone synthesis. Cells. 9(10):2323.","journal-title":"Cells"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30334"},{"issue":"1","key":"e_1_3_4_116_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/REP-20-0643","article-title":"Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway","volume":"162","author":"Xie F","year":"2021","unstructured":"Xie F et al. 2021. Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway. Reproduction. 162(1):73\u201382.","journal-title":"Reproduction"},{"issue":"4","key":"e_1_3_4_117_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nn.3960","article-title":"Mitochondrial control by DRP1 in brain tumor initiating cells","volume":"18","author":"Xie Q","year":"2015","unstructured":"Xie Q et al. 2015. Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci. 18(4):501\u2013510.","journal-title":"Nat Neurosci"},{"key":"e_1_3_4_118_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1470717"},{"key":"e_1_3_4_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-024-01337-0"},{"key":"e_1_3_4_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-025-01818-9"},{"key":"e_1_3_4_121_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20941"},{"issue":"1","key":"e_1_3_4_122_1","first-page":"E91","article-title":"Melatonin ameliorates excessive PINK1\/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS","volume":"319","author":"Yi S","year":"2020","unstructured":"Yi S et al. 2020. Melatonin ameliorates excessive PINK1\/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS. Am J Physiol-Endoc M. 319(1):E91\u2013E101.","journal-title":"Am J Physiol-Endoc M"},{"issue":"10","key":"e_1_3_4_123_1","doi-asserted-by":"crossref","first-page":"e0306152","DOI":"10.1371\/journal.pone.0306152","article-title":"Maternal total sleep deprivation causes oxidative stress and mitochondrial dysfunction in oocytes associated with fertility decline in mice","volume":"19","author":"Yi ZY","year":"2024","unstructured":"Yi ZY et al. 2024. Maternal total sleep deprivation causes oxidative stress and mitochondrial dysfunction in oocytes associated with fertility decline in mice. PLOS ONE. 19(10):e0306152.","journal-title":"PLOS ONE"},{"key":"e_1_3_4_124_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018228"},{"key":"e_1_3_4_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020564"},{"key":"e_1_3_4_126_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cca.2019.11.003","article-title":"Mo Z cheng. Polycystic ovarian syndrome: correlation between hyperandrogenism, insulin resistance and obesity","volume":"502","author":"Zeng X","year":"2020","unstructured":"Zeng X, Jie XY, Liu YT, Long SL. 2020. Mo Z cheng. Polycystic ovarian syndrome: correlation between hyperandrogenism, insulin resistance and obesity. Clinica (Rome) Acta. 502:214\u2013221.","journal-title":"Clinica (Rome) Acta"},{"key":"e_1_3_4_127_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-020-00489-4"},{"key":"e_1_3_4_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103526"},{"key":"e_1_3_4_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0961-2"},{"issue":"12","key":"e_1_3_4_130_1","doi-asserted-by":"crossref","first-page":"e240303","DOI":"10.1530\/EC-24-0303","article-title":"Melatonin attenuates hepatic oxidative stress by regulating the P62\/LC3 autophagy pathway in PCOS","volume":"13","author":"Zhang J","year":"2024","unstructured":"Zhang J et al. 2024. Melatonin attenuates hepatic oxidative stress by regulating the P62\/LC3 autophagy pathway in PCOS. Endocr Connections. 13(12):e240303.","journal-title":"Endocr Connections"},{"key":"e_1_3_4_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/reprod\/xaag041\/"},{"key":"e_1_3_4_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1094616"},{"key":"e_1_3_4_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.494"},{"key":"e_1_3_4_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.01.050"},{"key":"e_1_3_4_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01839-8"},{"key":"e_1_3_4_136_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.61379"}],"container-title":["Chronobiology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07420528.2026.2723197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/07420528.2026.2723197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07420528.2026.2723197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:37:12Z","timestamp":1788788232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07420528.2026.2723197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":135,"alternative-id":["10.1080\/07420528.2026.2723197"],"URL":"https:\/\/doi.org\/10.1080\/07420528.2026.2723197","relation":{},"ISSN":["0742-0528","1525-6073"],"issn-type":[{"value":"0742-0528","type":"print"},{"value":"1525-6073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icbi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icbi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}