{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:42:50Z","timestamp":1790066570739,"version":"4.0.1"},"reference-count":50,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100581"],"award-info":[{"award-number":["81100581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bethune\u00b7Merck Diabetes Research Fund","award":["2018 to S Shao"],"award-info":[{"award-number":["2018 to S Shao"]}]},{"name":"Wu Jieping Medical Foundation Special fund for clinical research","award":["2020 to S Shao"],"award-info":[{"award-number":["2020 to S Shao"]}]},{"name":"Cardiac rehabilitation and metabolic therapy research fund","award":["2018 to S Shao"],"award-info":[{"award-number":["2018 to S Shao"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1080\/07853890.2021.1925147","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T05:55:00Z","timestamp":1626242100000},"page":"1100-1108","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Trimetazidine ameliorates hindlimb ischaemic damage in type 2 diabetic mice"],"prefix":"10.1080","volume":"53","author":[{"given":"Yan","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology","place":["Wuhan, PR China"]},{"name":"Branch of national clinical research center for metabolic diseases","place":["Hubei, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology","place":["Wuhan, PR China"]},{"name":"Branch of national clinical research center for metabolic diseases","place":["Hubei, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Tongji Hospital, Huazhong University of Science & Technology","place":["Wuhan, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Shao","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology","place":["Wuhan, PR China"]},{"name":"Branch of national clinical research center for metabolic diseases","place":["Hubei, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMvcm1406358"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.01.018"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.10.019"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.19.2570"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303849"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.8.1433"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.022"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0005-0"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303505"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.049"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319714530040"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319718780551"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2527"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2.5.857"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12250"},{"issue":"45","key":"e_1_3_3_17_1","first-page":"207","article-title":"Trimetazidine: a second look. Just a placebo","volume":"9","year":"2000","unstructured":"Trimetazidine: a second look. Just a placebo. Prescrire Int. 2000;9(45):207\u2013209.","journal-title":"Prescrire Int"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.10.022"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0849-1"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvv051"},{"issue":"7","key":"e_1_3_3_21_1","first-page":"49","article-title":"Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina","volume":"43","author":"Syrkin AL","year":"2003","unstructured":"Syrkin AL, Artiukhina EG, Kanorski\u012d SG, et\u00a0al. Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina. Kardiologiia. 2003;43(7):49\u201352.","journal-title":"Kardiologiia"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.01.003"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.185"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000079225.50817.71"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.09.014"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1583"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2007.06.014"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000376"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.028"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.12.010"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005090"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93825"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.10024"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00980"},{"issue":"9","key":"e_1_3_3_35_1","first-page":"16991","article-title":"Mesenchymal stem cells preconditioned with trimetazidine promote neovascularization of hearts under hypoxia\/reoxygenation injury","volume":"8","author":"Hu X","year":"2015","unstructured":"Hu X, Yang J, Wang Y, et\u00a0al. Mesenchymal stem cells preconditioned with trimetazidine promote neovascularization of hearts under hypoxia\/reoxygenation injury. Int J Clin Exp Med. 2015;8(9):16991\u201317005.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.02.014"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.2.185"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.18.1.0287"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.5.853"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0026-1"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.043"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49473-7"},{"issue":"4","key":"e_1_3_3_43_1","first-page":"135","article-title":"The effect of trimetazidine on C-reactive protein, cytokines and adhesion molecules in the course of acute myocardial infarction","volume":"44","author":"Pudil R","year":"2001","unstructured":"Pudil R, Pidrman V, Krejsek J, et\u00a0al. The effect of trimetazidine on C-reactive protein, cytokines and adhesion molecules in the course of acute myocardial infarction. Acta Med . 2001;44(4):135\u2013140.","journal-title":"Acta Med"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.150839"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.949765"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1072805"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.137"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.11.011"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0063-8"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23044"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00897"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2021.1925147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:35:06Z","timestamp":1756964106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2021.1925147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1080\/07853890.2021.1925147"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2021.1925147","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-31","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}