{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:26:59Z","timestamp":1793384819805,"version":"4.5.0"},"reference-count":93,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1080\/07853890.2021.1925150","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T11:53:44Z","timestamp":1622116424000},"page":"750-761","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":110,"title":["Influence of gut microbiota on eye diseases: an overview"],"prefix":"10.1080","volume":"53","author":[{"given":"Pasquale","family":"Napolitano","sequence":"first","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise","place":["Campobasso, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaelena","family":"Filippelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise","place":["Campobasso, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Davinelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise","place":["Campobasso, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bartollino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise","place":["Campobasso, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"dell\u2019Omo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise","place":["Campobasso, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Costagliola","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise","place":["Campobasso, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160510"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400731"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7010014"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0264-8"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083115-022438"},{"key":"e_1_3_2_7_1","article-title":"The NIH human microbiome project","author":"Peterson J","year":"2009","unstructured":"Peterson J, Garges S, Giovanni M, et al. The NIH human microbiome project. Genome Res. 2009.","journal-title":"Genome Res"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06244"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000465"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.02.019"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.06.008"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-018-0148-5"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22677"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0097-2"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00232"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105684"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24813"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.014"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3911"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00006-09"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5065703"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.01.001"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170494"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1969"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9129163"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23643"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19733"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111677"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.018"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2004"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-322X.150799"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370218813616"},{"issue":"14","key":"e_1_3_2_33_1","article-title":"Dry age-related macular degeneration: Mechanisms, therapeutic targets, and imaging","volume":"54","author":"Bowes Rickman C","year":"2013","unstructured":"Bowes Rickman C, Farsiu S, Toth CA, et al. Dry age-related macular degeneration: Mechanisms, therapeutic targets, and imaging. Investig Ophthalmol Vis Sci. 2013;54(14):ORSF68-80.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2012.01134.x"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00171-12"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40826"},{"key":"e_1_3_2_37_1","article-title":"Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration","author":"Rowan S","year":"2018","unstructured":"Rowan S, Taylor A. Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration. Proc Natl Acad Sci USA. 2018.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165886"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010667"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-020-00257-5"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02773.x"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.01.013"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0292"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496153"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx184"},{"key":"e_1_3_2_48_1","first-page":"146","article-title":"Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma","volume":"14","author":"Challa P","year":"2008","unstructured":"Challa P, et al. Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma. Mol Vis. 2008;14:146\u2013149.","journal-title":"Mol Vis"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.11.004"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9596"},{"issue":"4","key":"e_1_3_2_51_1","first-page":"1219","article-title":"Helicobacter pylori (H. pylori) molecular signature in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma","volume":"19","author":"Chan CC","year":"2004","unstructured":"Chan CC, Smith JA, Shen DF, et al. Helicobacter pylori (H. pylori) molecular signature in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma. Histol Histopathol. 2004;19(4):1219\u20131226.","journal-title":"Histol Histopathol"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-12-199406150-00001"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i4.400"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.8.1050"},{"key":"e_1_3_2_55_1","first-page":"454","article-title":"Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans","volume":"22","author":"Collins DW","year":"2016","unstructured":"Collins DW, et al. Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans. Mol Vis. 2016;22:454\u2013471.","journal-title":"Mol Vis"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-257"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1575"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1474-4"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104416"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.07.014"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2015.07.015"},{"issue":"28","key":"e_1_3_2_62_1","article-title":"Helicobacter pylori infection and eye diseases: A systematic review","volume":"93","author":"Sacc\u00e0 SC","year":"2014","unstructured":"Sacc\u00e0 SC, Vagge A, Pulliero A, et al. Helicobacter pylori infection and eye diseases: A systematic review. Med. (United States). 2014;93(28):e216.","journal-title":"Med. (United States)"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.03.011"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17059"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6096"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0779-5"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330053"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70081-2"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S162135"},{"issue":"3","key":"e_1_3_2_70_1","first-page":"151","article-title":"Preoperative disinfection of the conjunctival sac with antibiotics and iodine compounds: A prospective randomized multicenter study","volume":"52","author":"Inoue Y","year":"2008","unstructured":"Inoue Y, Usui M, Ohashi Y, et al. Preoperative disinfection of the conjunctival sac with antibiotics and iodine compounds: A prospective randomized multicenter study. J Ophthalmol. 2008;52(3):151\u2013161.","journal-title":"J Ophthalmol"},{"key":"e_1_3_2_71_1","article-title":"Comparative lid flora in anterior blepharitis","author":"Kula\u00e7o\u01e7lu DN","year":"2001","unstructured":"Kula\u00e7o\u01e7lu DN, et al. Comparative lid flora in anterior blepharitis. Turkish J Med Sci. 200131:359-363.","journal-title":"Turkish J Med Sci"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.12.024"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0682-6"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-019-1118-x"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31821de36f"},{"key":"e_1_3_2_76_1","article-title":"Ocular demodicidosis as a risk factor of adult recurrent chalazion","author":"Yam JCS","year":"2013","unstructured":"Yam JCS, Tang BSF, Chan TM, et al. Ocular demodicidosis as a risk factor of adult recurrent chalazion. Eur. J. Ophthalmol. 2013.","journal-title":"Eur. J. Ophthalmol"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2008.01714.x"},{"key":"e_1_3_2_78_1","article-title":"Linear chalaziosis","author":"Bonifazi E.","year":"2005","unstructured":"Bonifazi E. Linear chalaziosis. Eur J Pediatr Dermatol. 2005.","journal-title":"Eur J Pediatr Dermatol"},{"issue":"3","key":"e_1_3_2_79_1","first-page":"325","article-title":"Human microbiota and ophthalmic disease","volume":"89","author":"Lu LJ","year":"2016","unstructured":"Lu LJ, Liu J. Human microbiota and ophthalmic disease. Yale J Biol Med. 2016;89(3):325\u2013330.","journal-title":"Yale J Biol Med"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12308"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03880-5"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1086\/320518"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071398"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.07.008"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099252"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6939"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12810"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2016.04.004"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23561"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.06.004"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5041417"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.75"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00979"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2017.04.005"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2021.1925150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:33:58Z","timestamp":1756964038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2021.1925150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":93,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1080\/07853890.2021.1925150"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2021.1925150","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}