{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:13:49Z","timestamp":1786947229945,"version":"build-2736575974"},"reference-count":72,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Y.S.P. Industries (M) Sdn. Bhd"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2023,12,12]]},"DOI":"10.1080\/07853890.2023.2270502","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T23:09:21Z","timestamp":1697756961000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Simultaneous determination of tramadol and paracetamol in human plasma using LC-MS\/MS and application in bioequivalence study of \u00adfixed-dose combination"],"prefix":"10.1080","volume":"55","author":[{"given":"Gabriel Onn Kit","family":"Loh","sequence":"first","affiliation":[{"name":"Bioxis Sdn. Bhd., Taman Perindustrian Bukit Minyak, Simpang Ampat, Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Yii Ling","family":"Wong","sequence":"additional","affiliation":[{"name":"Bioxis Sdn. Bhd., Taman Perindustrian Bukit Minyak, Simpang Ampat, Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen Zhu","family":"Goh","sequence":"additional","affiliation":[{"name":"Bioxis Sdn. Bhd., Taman Perindustrian Bukit Minyak, Simpang Ampat, Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Tze Fung","family":"Tan","sequence":"additional","affiliation":[{"name":"Bioxis Sdn. Bhd., Taman Perindustrian Bukit Minyak, Simpang Ampat, Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Clinical Trial, Institute for Clinical Research, Ampang Hospital, Ministry of Health, Jalan Mewah Utara, Ampang, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Hui","family":"Pang","sequence":"additional","affiliation":[{"name":"Centre for Clinical Trial, Institute for Clinical Research, Ampang Hospital, Ministry of Health, Jalan Mewah Utara, Ampang, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Halimah","family":"Shahridzo","sequence":"additional","affiliation":[{"name":"Centre for Clinical Trial, Institute for Clinical Research, Ampang Hospital, Ministry of Health, Jalan Mewah Utara, Ampang, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nair","family":"Damenthi","sequence":"additional","affiliation":[{"name":"Centre for Clinical Trial, Institute for Clinical Research, Ampang Hospital, Ministry of Health, Jalan Mewah Utara, Ampang, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi","family":"Hermansyah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiau Ming","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia"},{"name":"Pengiran Anak Puteri Rashidah Sa\u2019adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam"},{"name":"School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Khiang","family":"Peh","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00578.x"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.03.029"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-011-0168-0"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21596"},{"issue":"1","key":"e_1_3_5_6_1","first-page":"11","article-title":"Paracetamol: mechanism of action, applications and safety concern","volume":"71","author":"J\u00f3\u017awiak-Bebenista M","year":"2014","unstructured":"J\u00f3\u017awiak-Bebenista M, Nowak JZ. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 2014;71(1):11\u201323.","journal-title":"Acta Pol Pharm"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200060010-00008"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00355.x"},{"key":"e_1_3_5_9_1","unstructured":"U.S. Food and Drug Administration. Ultracet (325\u2009mg acetaminophen\/37.5\u2009mg tramadol hydrochloride) tablets. R. W. Johnson Pharmaceutical Research Institute. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2001\/21123_Ultracet.cfm"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363110-00007"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S33112"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9673(99)00028-x"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.584"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.01.038"},{"issue":"1","key":"e_1_3_5_15_1","article-title":"Determination of tramadol in human plasma by HPLC with fluorescence detection","volume":"3","author":"Baconi DL","year":"2016","unstructured":"Baconi DL, Stan M, Abdul Jalil Ebrahim Z, et\u00a0al. Determination of tramadol in human plasma by HPLC with fluorescence detection. J Mind Med Sci. 2016;3(1) Article 7.","journal-title":"J Mind Med Sci"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.11.034"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-4347(97)00267-3"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9673(01)01567-9"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0731-7085(01)00448-4"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.02.025"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.11-457"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9ra08717f"},{"issue":"3","key":"e_1_3_5_23_1","first-page":"34","article-title":"Development and validation of a spectrophotometric method for the determination of tramadol in human urine using liquid-liquid extraction and ion pair formation","volume":"1","author":"Ismaiel OA","year":"2012","unstructured":"Ismaiel OA, Hosny MM. Development and validation of a spectrophotometric method for the determination of tramadol in human urine using liquid-liquid extraction and ion pair formation. Int J Instrum Sci. 2012;1(3):34\u201340.","journal-title":"Int J Instrum Sci"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.04.006"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0731-7085(03)00573-9"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0731-7085(02)00174-7"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.03.016"},{"key":"e_1_3_5_28_1","doi-asserted-by":"crossref","unstructured":"Soysa P Kolambage S. Rapid HPLC\/UV method for analysis of urinary and plasma\/serum paracetamol concentrations. J Natl Sci Found. 2010;38:(2):131\u2013137.","DOI":"10.4038\/jnsfsr.v38i2.2039"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0731-7085(99)00051-5"},{"key":"e_1_3_5_30_1","first-page":"95","article-title":"Simultaneous determination of six analgesics in human plasma using solid-phase extraction and liquid chromatography","volume":"29","author":"Fern\u00e1ndez P","year":"2012","unstructured":"Fern\u00e1ndez P, Taboada V, Bermejo AM, et\u00a0al. Simultaneous determination of six analgesics in human plasma using solid-phase extraction and liquid chromatography. Rev Toxicol. 2012;29:95\u201399.","journal-title":"Rev Toxicol"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmt174"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.11.031"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2015.02.008"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2017v9i5.17746"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2019.104093"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.02.019"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.7976"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-4347(00)84010-4"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.06.012"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-007-0268-9"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.02.071"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422012001000012"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-4347(00)00318-2"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9673(99)01252-2"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.12793\/tcp.2016.24.1.30"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S64261"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bks139"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-016-0145-9"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.11.012"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2018-0039"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-008-0560-3"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.10.009"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.01.005"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2018.01.006"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4232"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2019.104146"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/30.7.463"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1605950"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.10.030"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/34.7.367"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.02.027"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.07.009"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1850"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2012.12.039"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21492"},{"key":"e_1_3_5_66_1","unstructured":"European Medicines Agency. Guideline on bioanalytical method validation. Committee for Medicinal Products for Human Use. 2012. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-bioanalytical-method-validation_en.pdf"},{"key":"e_1_3_5_67_1","unstructured":"Food and Drug Administration. Guidance for industry: bioanalytical method validation. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Veterinary Medicine (CVM). 2018. Available from: https:\/\/www.fda.gov\/files\/drugs\/published\/Bioanalytical-Method-Validation-Guidance-for-Industry.pdf"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.03.003"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2020.122337"},{"key":"e_1_3_5_70_1","volume-title":"Design and analysis of bioavailability and bioequivalence studies","author":"Chow SC","year":"2009","unstructured":"Chow SC, Liu JP. Design and analysis of bioavailability and bioequivalence studies. 3rd ed. New York (NY): CRC Press, Taylor & Francis Group; 2009.","edition":"3"},{"key":"e_1_3_5_71_1","unstructured":"European Medicines Agency. ASEAN guideline for the conduct of bioequivalence studies. 2015. Available from: https:\/\/asean.org\/wp-content\/uploads\/2012\/10\/BE_Guideline_FinalMarch2015_endorsed_22PPWG.pdf"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2019-0146"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55761-z"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2023.2270502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T12:06:51Z","timestamp":1708430811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2023.2270502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,12,12]]}},"alternative-id":["10.1080\/07853890.2023.2270502"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2023.2270502","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,19]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2270502"}}