{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:32:29Z","timestamp":1753875149170,"version":"3.41.2"},"reference-count":131,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/07853890.2024.2322047","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:33:28Z","timestamp":1734687208000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Bioengineering and omics approaches for Type 1 diabetes practical research: advancements and constraints"],"prefix":"10.1080","volume":"57","author":[{"given":"Xi","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangju","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenmei","family":"An","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107842"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13562"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-078432"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188583"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.233"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.894422"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4524-8"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0430-6"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.06.071"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00908"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11085-z"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1250126"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3211"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2023.01.012"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000608"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2022-0210"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00797-x"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2022.109118"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35145"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2631-z"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23295-6"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.10.003"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2016.08.005"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-02055-5"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108067"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-00762-x"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.03.013"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.08.001"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.3791\/57599"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2020.100192"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100466"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.021"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719869004"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0259043"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01518-2"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.06.008"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios12050302"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9lc00253g"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax4520"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137017"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110892"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2712-z"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00223-4"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203368"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27151"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b02224"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14815-w"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103495"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078706"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17040-8"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.195"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.867663"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.3791\/62207"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00043.2021"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.602519"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2316"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000171"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8885-3_20"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134525"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4416-y"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0687"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005046"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2740-2_14"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102684"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05168-7"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102399"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.2337\/db22-0952"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05345-8"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.034"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1184"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.04.011"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121342"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2022.01.003"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202200064"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.032"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-021-01177-y"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2019.10.004"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121566"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbac062"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14070371"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13462"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/acb02e"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765202120190942"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.01.042"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200807R"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13040684"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.3791\/58302"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137005"},{"key":"e_1_3_5_90_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1025711401572"},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.057"},{"key":"e_1_3_5_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.03.054"},{"key":"e_1_3_5_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120613"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210268"},{"key":"e_1_3_5_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119766"},{"key":"e_1_3_5_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13040171"},{"key":"e_1_3_5_97_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4276928"},{"key":"e_1_3_5_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-018-0096-5"},{"key":"e_1_3_5_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00088"},{"key":"e_1_3_5_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602740103"},{"key":"e_1_3_5_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2021.10214"},{"key":"e_1_3_5_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-022-00262-3"},{"key":"e_1_3_5_103_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012616"},{"key":"e_1_3_5_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2022.151928"},{"key":"e_1_3_5_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001123"},{"key":"e_1_3_5_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-020-00296-y"},{"key":"e_1_3_5_107_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/acb7bf"},{"key":"e_1_3_5_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112667"},{"key":"e_1_3_5_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001364"},{"key":"e_1_3_5_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13353"},{"key":"e_1_3_5_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-019-6287-x"},{"key":"e_1_3_5_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-018-1017-6"},{"key":"e_1_3_5_113_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328217752859"},{"key":"e_1_3_5_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.05.066"},{"key":"e_1_3_5_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.09.022"},{"key":"e_1_3_5_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.035"},{"key":"e_1_3_5_117_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1086"},{"key":"e_1_3_5_118_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.151621"},{"key":"e_1_3_5_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.04.005"},{"key":"e_1_3_5_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123585"},{"key":"e_1_3_5_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01103-1"},{"key":"e_1_3_5_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201267119"},{"key":"e_1_3_5_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00531-x"},{"key":"e_1_3_5_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103099"},{"key":"e_1_3_5_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05801-7"},{"key":"e_1_3_5_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.02.012"},{"key":"e_1_3_5_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104379"},{"key":"e_1_3_5_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2022.104746"},{"key":"e_1_3_5_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00842"},{"key":"e_1_3_5_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.06.001"},{"key":"e_1_3_5_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.12.019"},{"key":"e_1_3_5_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11030383"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2024.2322047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:33:32Z","timestamp":1734687212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2024.2322047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":131,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/07853890.2024.2322047"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2024.2322047","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"type":"print","value":"0785-3890"},{"type":"electronic","value":"1365-2060"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2322047"}}