{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:32:06Z","timestamp":1788564726916,"version":"build-2803163510"},"reference-count":52,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82272313"],"award-info":[{"award-number":["82272313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/07853890.2025.2595332","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T13:12:16Z","timestamp":1765113136000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["ANXA3 hypomethylation as a prognostic biomarker in hepatitis B virus-related acute-on-chronic liver failure"],"prefix":"10.1080","volume":"57","author":[{"given":"Zhaohui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Severe Liver Disease, Shandong Public Health Clinical Center of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital (Qingdao) of Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital (Qingdao) of Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University","place":["Jinan, China"]},{"name":"Hepatology Institute of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7868-6263","authenticated-orcid":false,"given":"Chao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University Dezhou Hospital","place":["Dezhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Qilu Hospital of Shandong University","place":["Jinan, China"]},{"name":"Hepatology Institute of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15733"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15328"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323395"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14927"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S506050"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2400"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1433-4"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.11.003"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.05.013"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107139"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.034"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6402-0"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.052"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-025-02287-4"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2024.01.006"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27717"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13631"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.861459"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140715029"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00907-4"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-024-02346-6"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112686"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.07.017"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep04432"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32984"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1267844"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13271"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-13-2642"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314641"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09946-3"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.746643"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-00967-4"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00520-7"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.953297"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04294-1"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.4230102"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.08.008"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.657076"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.890941"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29792-6"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01763-2"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.09.008"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-023-00306-2"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108456"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0659-3"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.4495"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2024.153875"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4545"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13239"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1421597"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2025.2595332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T13:12:17Z","timestamp":1765113137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2025.2595332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/07853890.2025.2595332"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2025.2595332","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2595332"}}