{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:13:23Z","timestamp":1793862803434,"version":"4.6.1"},"reference-count":51,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/07853890.2025.2595874","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T03:25:49Z","timestamp":1764818749000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy and safety of IL-23p19 and IL-12\/23p40 inhibitors in moderate-to-severe Crohn\u2019s disease: a systematic review and network meta-analysis"],"prefix":"10.1080","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3068-8125","authenticated-orcid":false,"given":"Motoki","family":"Kaneko","sequence":"first","affiliation":[{"name":"Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-6129","authenticated-orcid":false,"given":"Atsushi","family":"Sakuraba","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)02586-2"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.042"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-17431-8"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)32448-0"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.06.002"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(24)00044-x"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-025-02183-z"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01740-6"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101748"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312518"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(21)00312-5"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328052"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18110"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-025-03183-x"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2018.27"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2025.2511148"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283x17750355"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212196"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602773"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.982238"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135245"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.175"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci21404"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2314585"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)01762-8"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003082"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.01.047"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(23)00318-7"},{"key":"e_1_3_5_32_1","volume-title":"ACR Convergence","year":"2024","unstructured":"Panaccione R, DaneseS, Feagan B, et al. Efficacy and safety of guselkumab therapy in patients with moderately to severely active Crohn\u2019s disease: results of the GALAXI 2 and 3 phase 3 studies [abstract]. ACR Convergence. 2024. Nov; San Diego, CA, USA2024."},{"key":"e_1_3_5_33_1","doi-asserted-by":"crossref","unstructured":"Panaccione R Danese S Feagan B et al.; Sep 26\u201328 2024; Nashville TN USA2024. et al. Efficacy and safety of guselkumab therapy in patients with moderately to severely active Crohn\u2019s diseaseresults of the GALAXI 2 and 3 phase 3 studies [abstract]. Rheumatology Advanced Practice Providers (RhAPP); 2024","DOI":"10.1016\/S0016-5085(24)05019-4"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.02.033"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae190.0843"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.050"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)30570-6"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(22)00467-6"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(22)00466-4"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203572"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.035"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz115"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1532852"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0126-0"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168947"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2019.1664365"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.122.001512"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13706"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13379"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260954"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.3.6.17815"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy13030073"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2025.2595874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T08:49:03Z","timestamp":1766134143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2025.2595874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/07853890.2025.2595874"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2025.2595874","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2595874"}}