{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:33:13Z","timestamp":1790886793469,"version":"4.1.0"},"reference-count":85,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2508085QH332"],"award-info":[{"award-number":["2508085QH332"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274490"],"award-info":[{"award-number":["82274490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205090"],"award-info":[{"award-number":["82205090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Traditional Chinese Medicine Inheritance and Innovation Project Fund","award":["[2022] No. 366"],"award-info":[{"award-number":["[2022] No. 366"]}]},{"name":"National High Level Key Discipline of Traditional Chinese Medicine, Traditional Chinese Medicine Arthralgia","award":["Chinese Medicine Ren Jiao Han [2023] No. 85"],"award-info":[{"award-number":["Chinese Medicine Ren Jiao Han [2023] No. 85"]}]},{"name":"Xin\u2019an Jianpi Tongbi Formula","award":["2024YFYLCZX36"],"award-info":[{"award-number":["2024YFYLCZX36"]}]},{"name":"Clinical Research Project of Anhui University of Traditional Chinese Medicine","award":["2024YFYLCZX09"],"award-info":[{"award-number":["2024YFYLCZX09"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/07853890.2025.2600171","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:21:48Z","timestamp":1765344108000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the ubiquitination regulatory network: opening new perspectives for rheumatoid arthritis therapy"],"prefix":"10.1080","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1824-9213","authenticated-orcid":false,"given":"Fanfan","family":"Wang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, China"]},{"name":"Department of Rheumatism Immunity, The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-7553","authenticated-orcid":false,"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, China"]},{"name":"Department of Rheumatism Immunity, The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Rheumatism Immunity, The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatism Immunity, The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"He","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, China"]},{"name":"Department of Rheumatism Immunity, The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.11.009"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000937316.70181.ff"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/166dsf"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2023.2297798"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201703170"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00128"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060310-170328"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014922"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-044916"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0099-1"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.874"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107224"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21675"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.39"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-051810-094654"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2020.11.004"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3982"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2019.08.004"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2015.486"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109736"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309560"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2022.102304"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12876"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01193-1"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.12701\/jyms.2022.00773"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-1894"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.37"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8295149"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-024-10737-1"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.12940"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.12.011"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202080"},{"issue":"5","key":"e_1_3_4_36_1","first-page":"S40","article-title":"The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis","volume":"34","author":"van Riel PL","year":"2016","unstructured":"van Riel PL, Renskers L. The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis. Clin Exp Rheumatol. 2016;34(5 Suppl 101):S40\u2013s44.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41446"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2282-3"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2015.01.008"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00849-0"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2094"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24220"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2015.30.3.233"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0331-5"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.13423\/j.cnki.cjcmi.007694"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113000"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3109135"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.853194"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-00990-4"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.08.017"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18050905"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.2741\/1817"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1412"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg037"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06580.x"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39563"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-273417"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.841732"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1939-1"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.912933"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxq470"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac072"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae595"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42856"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2081"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6728694"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135935"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1096603"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608773104"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00692-2"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40504"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13762"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39608"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01743"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.07.013"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1129"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202100367"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04695-y"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-024-00416-3"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012476"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.10.015"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.047"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11748"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002475"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00117"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.12.021"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2025.2600171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:21:50Z","timestamp":1765344110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2025.2600171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/07853890.2025.2600171"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2025.2600171","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2600171"}}