{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:38:36Z","timestamp":1788824316295,"version":"build-2803163510"},"reference-count":116,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","award":["R01MH111276"],"award-info":[{"award-number":["R01MH111276"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/07853890.2025.2611202","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:17:08Z","timestamp":1767939428000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":5,"title":["Central hypocretin\/orexin administration alleviates sleep\/wake disturbances, anhedonia, and neuroinflammation in an animal model of seasonal affective disorder"],"prefix":"10.1080","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7119-3194","authenticated-orcid":false,"given":"Allison","family":"Costello","sequence":"first","affiliation":[{"name":"Department of Psychology, Behavioral Neuroscience Program","place":["East Lansing, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Linning-Duffy","sequence":"additional","affiliation":[{"name":"Department of Psychology, Behavioral Neuroscience Program","place":["East Lansing, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Psychology, Behavioral Neuroscience Program","place":["East Lansing, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Lonstein","sequence":"additional","affiliation":[{"name":"Department of Psychology, Behavioral Neuroscience Program","place":["East Lansing, USA"]},{"name":"Neuroscience Program, Michigan State University","place":["East Lansing, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-2542","authenticated-orcid":false,"given":"Lily","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Psychology, Behavioral Neuroscience Program","place":["East Lansing, USA"]},{"name":"Neuroscience Program, Michigan State University","place":["East Lansing, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.1993.17"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790120076010"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.163.3.338"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06111792"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.2871"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2008.10.4\/jmendlewicz"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14172"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0804"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730403256651"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2018.09.003"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.12.004"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057115"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.002"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22822"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.01.031"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00072"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.06.038"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.04.069"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15248"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-022-01256-x"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2249015"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.10.010"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0031442"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3200-12.2013"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151288"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23376"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873048800300203"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602425103"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.163.3.332"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90074-n"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810160043008"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06188blu"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0924270800037522"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-9384(97)00146-7"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3936"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-7-14"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.11.004"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.04.012"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/07487304231170068"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-022-01427-8"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22424"},{"key":"e_1_3_4_43_1","volume-title":"Vol. 1 of the rat brain in stereotaxic coordinates","author":"Paxinos G","year":"2007","unstructured":"Paxinos G, Watson C. Vol. 1 of the rat brain in stereotaxic coordinates. 6th ed. Amsterdam, Boston: Elsevier; 2007.","edition":"6"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13581-z"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1268-12.2013"},{"issue":"8","key":"e_1_3_4_46_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ijdevneu.2003.09.001","article-title":"Morphological development of microglia in the postnatal rat brain: a quantitative study","volume":"21","author":"Orlowski D","year":"2003","unstructured":"Orlowski D, Soltys Z, Janeczko K. Morphological development of microglia in the postnatal rat brain: a quantitative study. Int J Dev Neurosci. 2003;21(8):445\u2013450.","journal-title":"Int J Dev Neurosci"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.3791\/57648"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00235"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00003"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e36402"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3878-07.2007"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.12.045"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.06.015"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(02)00110-9"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.926825"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2017.10.014"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700983114"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.1058"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.03.004"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2009.02012.x"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.07.007"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-3-28"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.155496"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13902"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1817380"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.10.013"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(02)00052-9"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(99)01030-3"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200103050-00008"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086436"},{"issue":"4","key":"e_1_3_4_72_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1210\/en.2002-0030","article-title":"Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors","volume":"144","author":"Johren O","year":"2003","unstructured":"Johren O, et al. Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors. Endocrinology. 2003;144(4):1219\u20131225.","journal-title":"Endocrinology"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.8.3324"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.05.004"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063136"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.03.043"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111655"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2014.4816"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2010.00870.x"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4332-06.2006"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.07.026"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0011-z"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00125"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0450-11.2011"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2233"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.09.062"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.05.033"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.04.004"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/941413"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.6_supplement.321s"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(00)02398-2"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7604"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.08.033"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10264fp"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(02)00176-3"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.681700"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318206ff6f"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01841-1"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02235-7"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12101372"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0739-8"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1513-1"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.07.003"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00430"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111708"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22738"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01024"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9438-6"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.08.037"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166230"},{"key":"e_1_3_4_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.11.029"},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.03.019"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.02.087"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04315.x"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163780"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262955"},{"key":"e_1_3_4_117_1","unstructured":"Costello A. Light orexin and SAD: a mechanistic study using a diurnal rodent model. . :.Michigan State University\u2009ProQuest Dissertations & Theses \u20092024:31640069."}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2025.2611202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:17:10Z","timestamp":1767939430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2025.2611202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":116,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/07853890.2025.2611202"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2025.2611202","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2611202"}}