{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:28:15Z","timestamp":1792013295599,"version":"4.4.0"},"reference-count":149,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274247"],"award-info":[{"award-number":["82274247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/07853890.2026.2613484","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:10:38Z","timestamp":1769163038000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Gut microbiota in early and established stages of rheumatoid arthritis: from pathogenesis to promising prevention and treatment"],"prefix":"10.1080","volume":"58","author":[{"given":"Shuanglan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Hung","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"Quang Binh Medical College","place":["Quang Binh, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsen","family":"Hu","sequence":"additional","affiliation":[{"name":"Sichuan Jinxin Xi\u2019nan Women\u2019s and Children\u2019s Hospital Co., Ltd","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingman","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183836"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102777"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.12.009"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01202"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214514"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.763507"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327756"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac458"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113518"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0299-7"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-023-03260-y"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15802-x"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2021.04.013"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15831-7"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39785"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-023-03069-9"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42616"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac454"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102386"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-222035"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.1.57"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a030338"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12162"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12910"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76179"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120294"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2426"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2425"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201546094"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan0368"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909122107"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo00077a"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30594"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617460113"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.001"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.03.013"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501904"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39783"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad014"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.680073"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07196-7"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.002"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03727-5"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2564-6"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05711-8"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn5166"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102913"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40490"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.03.020"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-020-00960-1"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105192"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.43036"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02477-8"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115276"},{"issue":"6","key":"e_1_3_4_58_1","first-page":"656","article-title":"Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs","volume":"24","author":"Moen K","year":"2006","unstructured":"Moen K, Brun JG, Valen M, et al. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol. 2006;24(6):656\u2013663.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95997"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03235-w"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c05371"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601776"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20173"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.1.137"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119389"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-022-00912-0"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.692041"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40917"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036095"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30064-3"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.04.001"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40003"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93450"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3914"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez073"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2005.01575.x"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.4.2189"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78084"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15852"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.03.003"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm1511"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.17"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2021.152126"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-022-01284-6"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03880-9"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2021.12.010"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152586"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104055"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102564"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.01.018"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01525"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02490-4"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164196"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.799602"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01051"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI167671"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00934-6"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.07.009"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800285"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111090"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.670593"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.12.23"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i27.4344"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12888"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.09.007"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12333"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0436-y"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.736196"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.01.002"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01159"},{"key":"e_1_3_4_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.669889"},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.571049"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v60.30876"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263254"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121523"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10010048"},{"key":"e_1_3_4_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2024.100915"},{"key":"e_1_3_4_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.05.009"},{"key":"e_1_3_4_119_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.3.208"},{"key":"e_1_3_4_120_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319654"},{"key":"e_1_3_4_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020699"},{"key":"e_1_3_4_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.3.594s"},{"key":"e_1_3_4_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102392"},{"key":"e_1_3_4_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103207"},{"key":"e_1_3_4_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040325"},{"key":"e_1_3_4_126_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo00709b"},{"key":"e_1_3_4_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104603"},{"key":"e_1_3_4_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu330"},{"key":"e_1_3_4_129_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-056255"},{"key":"e_1_3_4_130_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.050245"},{"key":"e_1_3_4_131_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.086314"},{"key":"e_1_3_4_132_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608620104"},{"key":"e_1_3_4_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00204"},{"key":"e_1_3_4_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1187797"},{"key":"e_1_3_4_135_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900425RR"},{"key":"e_1_3_4_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2023.06.027"},{"key":"e_1_3_4_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104459"},{"key":"e_1_3_4_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2822-0"},{"key":"e_1_3_4_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21620"},{"key":"e_1_3_4_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11186"},{"key":"e_1_3_4_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1394-6"},{"key":"e_1_3_4_142_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez452"},{"key":"e_1_3_4_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3677"},{"key":"e_1_3_4_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41622"},{"key":"e_1_3_4_145_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000870"},{"key":"e_1_3_4_146_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2149020"},{"key":"e_1_3_4_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09361-0"},{"key":"e_1_3_4_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13479"},{"key":"e_1_3_4_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-013-0338-1"},{"key":"e_1_3_4_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801314"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2026.2613484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:10:42Z","timestamp":1769163042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2026.2613484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":149,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/07853890.2026.2613484"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2026.2613484","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2613484"}}