{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:18:44Z","timestamp":1783585124679,"version":"3.55.0"},"reference-count":29,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province","award":["2023Y9420"],"award-info":[{"award-number":["2023Y9420"]}]},{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province","award":["2023Y0057"],"award-info":[{"award-number":["2023Y0057"]}]},{"name":"Fujian Cancer Hospital High-level Talent Training Project","award":["2023YNG06(in-hospital project No. 4001024)"],"award-info":[{"award-number":["2023YNG06(in-hospital project No. 4001024)"]}]},{"name":"Fujian Provincial Health Commission Youth Scientific Research Project","award":["2024QNA056"],"award-info":[{"award-number":["2024QNA056"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/07853890.2026.2698360","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:54:42Z","timestamp":1783583682000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Randomized phase-II trial of surufatinib plus FOLFOX\/FOLFIRI versus FOLFOXIRI as second-line therapy for metastatic colorectal cancer"],"prefix":"10.1080","volume":"58","author":[{"given":"Liyu","family":"Su","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peicheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaisheng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhua","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Fujian Sanming First Hospital","place":["Sanming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinluan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Quanzhou First Hospital","place":["Quanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Administrative Office of Science and Technology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-1691","authenticated-orcid":false,"given":"Rongbo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital","place":["Fuzhou, China"]},{"name":"Fujian Key Laboratory of Translational Cancer Medicine","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_3_5_2_1","unstructured":"National comprehensive cancer network. NCCN clinical practice guidelines in oncology (NCCN Guidelines). Colon Cancer version 5; 2025. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/colon.pdf. Accessed January 8 2026."},{"key":"e_1_3_5_3_1","unstructured":"ESMO living guideline. Metastatic Colorectal Cancer Advanced and Metastatic Disease Without Potential Conversion version 1.3. https:\/\/www.esmo.org\/guidelines\/living-guidelines\/esmo-living-guideline-metastatic-colorectal-cancer\/advanced-and-metastatic-disease-without-potential-conversion. Accessed December 28; 2025."},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12639"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70477-1"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.6305"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.8201"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70127-0"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1600"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30862-9"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00122-9"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.0928"},{"issue":"11","key":"e_1_3_5_13_1","first-page":"132","article-title":"Efficacy and survival analysis of modified FOLFOXIRI regimen as second-line treatment for advanced colorectal cancer","volume":"29","author":"Lin R","year":"2017","unstructured":"Lin R, Liu J, Li H, et al. Efficacy and survival analysis of modified FOLFOXIRI regimen as second-line treatment for advanced colorectal cancer. Haixiayaoxue. 2017;29(11):132\u2013135.","journal-title":"Haixiayaoxue"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359211042689"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11102650"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9792"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.4_suppl.278"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107126"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0257-y"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30493-9"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30496-4"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.7855"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00772-9"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2011.06.013"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(11)70150-2"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mog2.69"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2015.572"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2994"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03898-8"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2026.2698360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/07853890.2026.2698360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890.2026.2698360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:54:43Z","timestamp":1783583683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890.2026.2698360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/07853890.2026.2698360"],"URL":"https:\/\/doi.org\/10.1080\/07853890.2026.2698360","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iann20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2698360"}}