{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:51:28Z","timestamp":1791427888241,"version":"4.3.3"},"reference-count":40,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Medicine"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1080\/07853890410028456","type":"journal-article","created":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T21:43:32Z","timestamp":1083966212000},"page":"225-231","source":"Crossref","is-referenced-by-count":13,"title":["Cardiovascular autonomic regulation in patients with 3243A>G mitochondrial DNA mutation"],"prefix":"10.1080","volume":"36","author":[{"given":"Kirsi","family":"Majamaa\u2010Voltti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Majamaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keijo","family":"Peuhkurinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"M\u00e4kikallio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Huikuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"CIT0001","first-page":"481","volume":"16","author":"Pavlakis SG","year":"1984","journal-title":"Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: a distinctive clinical syndrome. Ann Neur"},{"key":"CIT0002","first-page":"1713","volume":"120","author":"Chinnery PF","year":"1997","journal-title":"The relation-ship between mutation load and clinical phenotypes. Brain"},{"key":"CIT0003","first-page":"216","volume":"250","author":"K\u00e4rpp\u00e4 M","year":"2002","journal-title":"J Neurol"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.CIR.91.4.955","volume":"91","author":"Anan R","year":"1995","journal-title":"Circulation"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0008-6363(97)00141-7","volume":"35","author":"Antozzi C","year":"1997","journal-title":"Cardiovasc Res"},{"key":"CIT0007","first-page":"256","volume":"59","author":"Kleiger RE","year":"1987","journal-title":"Decreased heart rate varia-bility and its association with increased mortality after myocardial infarction. Am J Cardiol"},{"key":"CIT0008","first-page":"178","volume":"87","author":"M\u00e4kikallio T","year":"2001","journal-title":"Fractal analysis and time- and frequency-domain measures of heart rate variability as predictors of mortality in patients with heart failure. Am J Cardiol"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0735-1097(91)90791-7","volume":"18","author":"Farrel TG","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"CIT0010","first-page":"1395","volume":"37","author":"M\u00e4kikallio T","year":"2001","journal-title":"Prediction of sudden cardiac death by fractal analysis of heart rate variability in elderly subjects. J Am Coll Cardiol"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1161\/01.CIR.90.2.878","volume":"90","author":"Tsuji H","year":"1994","journal-title":"The Framingham Heart Study. Circulation"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/S0735-1097(99)00468-4","volume":"34","author":"Huikuri HV","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/01.CIR.101.1.47","volume":"101","author":"Huikuri HV","year":"2000","journal-title":"Circulation"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1161\/01.CIR.93.10.1836","volume":"93","author":"Huikuri HV","year":"1996","journal-title":"Circulation"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/003693305700200504","volume":"2","author":"Rankin J","year":"1957","journal-title":"2. Prognosis. Scot Med J"},{"key":"CIT0018","first-page":"218","author":"Guy E","year":"1976","journal-title":"Early Clinical Drug Evaluation (ECDEU) Assessment Manual for Psychopharma-cology.National Institute of Mental HealthRockville"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80013-6","volume":"2","author":"Schiller NB","year":"1989","journal-title":"J Am Soc Echocardiogr"},{"key":"CIT0020","first-page":"1073","volume":"77","author":"Huikuri HV","year":"1996","journal-title":"Heart rate variability in systemic hypertension. Am J Cardiol"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/01.CIR.100.4.393","volume":"100","author":"Pikkuj\u00e4ms\u00e4 SM","year":"1999","journal-title":"Circulation"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1161\/01.CIR.97.20.2031","volume":"97","author":"Huikuri HV","year":"1998","journal-title":"Circula-tion"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","volume":"93","author":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","year":"1996","journal-title":"Circulation"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1161\/01.CIR.93.12.2142","volume":"21","author":"Bigger JT","year":"1996","journal-title":"Circulation"},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1063\/1.166141","volume":"5","author":"Peng CK","year":"1995","journal-title":"Chaos"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1161\/01.CIR.96.3.842","volume":"96","author":"Ho KK","year":"1997","journal-title":"Circulation"},{"key":"CIT0027","first-page":"1519","volume":"14","author":"Airaksinen KEJ","year":"1993","journal-title":"Valsalva manoeuvre in the assess-ment of baroreflex sensitivity in patients with coronary artery disease. Eur Heart J"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0006-291X(05)80860-5","volume":"173","author":"Kobayashi Y","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0030","first-page":"687","volume":"84","author":"Burger AJ","year":"1999","journal-title":"Effect of glycemic control on heart rate variability in type I diabetic patients with cardiac autonomic neuropathy. Am J Cardiol"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0022-0736(92)90112-D","volume":"25","author":"Takase B","year":"1992","journal-title":"J Electrocardiol"},{"key":"CIT0032","first-page":"1364","volume":"126","author":"Chakko S","year":"1993","journal-title":"Alterations in heart rate variability and its circadian rhythm in hypertensive patients with left ventricular hypertrophy free of coronary artery disease. Am Heart J"},{"key":"CIT0033","first-page":"1206","volume":"8","author":"Petretta M","year":"1995","journal-title":"Power spectral analysis of heart period vari-ability in hypertensive patients with left ventricular hyper-trophy. Am J Hypertens"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1097\/00004872-199816110-00011","volume":"16","author":"Muiesan ML","year":"1998","journal-title":"J Hypertens"},{"key":"CIT0035","first-page":"164","volume":"85","author":"Bigger JT","year":"1992","journal-title":"Frequency domain measures of heart period variability and mortality after myocardial infarction. Circula-tion"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00400668","volume":"39","author":"Maassen JA","year":"1996","journal-title":"Diabetologia"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/01.HYP.28.1.16","volume":"28","author":"Perkiom\u00e4ki JS","year":"1996","journal-title":"Hypertension"},{"key":"CIT0038","first-page":"305","volume":"70","author":"Haapaniemi TH","year":"2001","journal-title":"Ambulatory ECG and analysis of heart rate variability in Parkinson's disease. J Neurol Neurosurg Psychiatry"},{"key":"CIT0039","first-page":"26","volume":"72","author":"Ansakorpi H","year":"2002","journal-title":"Heart rate dynamics in refractory and well controlled temporal lobe epilepsy. J Neurol Neurosurg Psychiatry"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.CIR.98.6.547","volume":"98","author":"Taylor JA","year":"1998","journal-title":"Circulation"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2281.2001.00344.x"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(75)90054-5"},{"key":"CIT0043","first-page":"234","volume":"32","author":"Bernardi L","year":"1996","journal-title":"Physical activity influences heart rate variability and very-low-fre-quency components in Holter electrocardiograms. Cardiovasc Res"},{"key":"CIT0044","first-page":"655","volume":"40","author":"Vissing J","year":"1996","journal-title":"Haller RG. Exercise fuel mobilisation in mitochondrial myopathy: a metabolic dilemma. Ann Neurol"}],"container-title":["Annals of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/07853890410028456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T11:23:29Z","timestamp":1526297009000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07853890410028456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,7,8]]},"published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1080\/07853890410028456"],"URL":"https:\/\/doi.org\/10.1080\/07853890410028456","relation":{},"ISSN":["0785-3890","1365-2060"],"issn-type":[{"value":"0785-3890","type":"print"},{"value":"1365-2060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}