{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:09:37Z","timestamp":1773421777895,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":2253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p><jats:bold>Aim: <\/jats:bold> Central apnoeas without an identifiable precipitating cause frequently occur in the neonatal period. Serious apnoeas should be treated with ventilation\u2010enhancing methylxanthines. Drugs such as opioids or prostaglandins (PGE<jats:sub>2<\/jats:sub>) are known to induce apnoea. PGE<jats:sub>2<\/jats:sub> is an endogenous hormone that plays an important role in the regulation of neural activity and a relationship between PGE<jats:sub>2<\/jats:sub> and central apnoeas has been postulated. <jats:italic>Methods<\/jats:italic>: In order to test the hypothesis that the incidence of central apnoeas in preterm infants is related to endogenous PGE concentration, we measured the urinary concentration of PGE<jats:sub>2<\/jats:sub> and PGE\u2010M and determined the number of central apnoeas &gt;10s\/12h in overnight polygraphy in 18 preterm infants with apnoeas, bradycardias and desaturations, and 18 normal controls. <jats:italic>Results<\/jats:italic>: We found 80.6 (SE 6.9) central apnoeas in the study group, and 52.9 (SE 4.1) in the control group (<jats:italic>p<\/jats:italic>= 0.002). Urinary PGE<jats:sub>2<\/jats:sub> concentration was 25.9 (SE 6.1)ng\/h\/1.73m<jats:sup>2<\/jats:sup> in the control, 31.2 (SE 15.8) ng\/h\/1.73m<jats:sup>2<\/jats:sup> in the study group (<jats:italic>p<\/jats:italic>= n.s.), PGE\u2010M concentration was 486 (SE 35) ng\/h\/1.73m<jats:sup>2<\/jats:sup> in the control and 1132 (SE 131) ng\/h\/1.73m<jats:sup>2<\/jats:sup> in the study group (<jats:italic>p<\/jats:italic> &lt; 0.0001). There was a significant correlation between the number of central apnoeas and the PGE\u2010M concentration in the study group (<jats:italic>r<\/jats:italic>= 0.68, <jats:italic>p<\/jats:italic> &lt; 0.0001).<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: Our results suggest a relationship between PGE and the respiratory system and open potential therapeutic options for the treatment of central apnoeas in neonates.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2000.tb00766.x","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T02:30:06Z","timestamp":1281148206000},"page":"1364-1368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Central apnoea and endogenous prostaglandins in neonates"],"prefix":"10.1111","volume":"89","author":[{"given":"B","family":"Hoch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bernhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80349-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30988-9"},{"key":"e_1_2_1_4_1","volume-title":"The international classification of sleep disorders. 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