{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:25:01Z","timestamp":1790101501331,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":2437,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p>Umbilical artery Doppler flow velocity waveform studies were performed over a period of 4 y on 242 women with severe pre\u2010eclampsia before 34 wk gestation. Sixty\u2010eight (28%) had absent end\u2010diastolic umbilical artery Doppler flow velocities. One hundred and ninety\u2010three infants survived to hospital discharge and were followed at 6\u2010monthly intervals until 48 mo of age. Fhe mean corrected developmental quotient was 94 \u00b1 8 at 24 mo of age and 87 \u00b1 9 at 48 mo. Ninety\u2010two percent of the infants had a developmental quotient of &gt;80 at 24 mo and 72% at 48 mo of age. Fhis decline is thought to be due to the impact of social circumstances. Fhere were no differences between the developmental quotients of the infants with normal and those with absent end\u2010diastolic umbilical artery Doppler flow velocities at either 24 or 48 mo of age. At 24 mo of age, infants with absent end\u2010diastolic umbilical artery Doppler flow velocities scored lower in the Performance subscale test (<jats:italic>p<\/jats:italic>= 0.03).<\/jats:p><jats:p>developmental quotients of infants from poorer socioeconomic backgrounds were significantly lower than those living in more privileged circumstances. At 48 mo, 153 (97%) of the children presented with normal gross motor development. Four infants had cerebral palsy. No differences were noted in the motor outcomes between the infants of women with normal umbilical artery waveforms and those with absent end\u2010diastolic umbilical artery Doppler flow velocities.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2000.tb00340.x","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T04:43:33Z","timestamp":1281156213000},"page":"566-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Infants of women with severe early pre\u2010eclampsia: the effect of absent end\u2010diastolic umbilical artery Doppler flow velocities on neurodevelopmental outcome"],"prefix":"10.1111","volume":"89","author":[{"given":"GF","family":"Kirsten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JI","family":"van Zyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"van 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