{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:33:12Z","timestamp":1791289992489,"version":"4.3.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":2192,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>In a representative series of 53 females with Rett syndrome (RS), aged 5\u201355 y, a history of epilepsy was present in 50 (94%), 45 of whom had 5\u2010y active epilepsy. Compared with severe mental retardation in general, the median age of seizure onset was significantly later (4 vs 0.8 y) and partial complex seizures were more frequent (54% vs 23%). Neonatal seizures had occurred in only one and infantile spasms in none compared with 26% and 12%. After teenage, the severity of epilepsy tended to decrease, i.e. lower seizure frequency and relatively more partial seizures. The rate of being seizure\u2010free for 1 y was 8% after 10 y and 40% after 27 y of epilepsy duration. Frequent seizures were associated with smaller head circumference.<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: This epilepsy profile could fit in with present\u2010day knowledge of RS as a form of dendrito\u2010synaptogenic developmental failure with mainly late postnatal consequences, as well as being a relatively stationary condition in adulthood.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2001.tb00252.x","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T02:05:07Z","timestamp":1281146707000},"page":"34-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["Epilepsy in a representative series of Rett syndrome"],"prefix":"10.1111","volume":"90","author":[{"given":"U","family":"Steffenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Hagberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Hagberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140412"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_2_1_4_1","first-page":"4","volume-title":"Rett syndrome\u2014clinical and biological aspects. 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