{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:24:28Z","timestamp":1790749468085,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":1827,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>This study investigated faecal calprotectin concentration, a measure of intestinal inflammation, in infants and children with abdominal pain. Faecal calprotectin was measured by an enzyme\u2010linked immunosorbent assay kit in spot stool samples in 76 infants with typical infantile colic, 7 infants with transient lactose intolerance and 27 healthy infants. All infants were 2\u201010 wk of age. In addition, 19 children with recurrent abdominal pain (RAP; mean age 11.5 y), 17 with inflammatory bowel disease (IBD; mean age 11.1 y; 10 had Crohn's disease and 7 ulcerative colitis) and 24 healthy children (mean age 5.3 y) were studied. In infants with infantile colic the mean faecal calprotectin concentration was not different from that in healthy infants (278 \u00b1 105 vs 277 \u00b1 109 mg kg<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>= 0.97) or in infants with transient lactose intolerance (300.3 \u00b1 124 mg kg<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>= 0.60). The calprotectin level was similar in boys and girls and fell significantly with age (p = 0.04). Children with IBD had faecal calprotectin levels (293 \u00b1 218 mgkg<jats:sup>\u22121<\/jats:sup>) much higher than healthy children (40 \u00b1 28 mg kg<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic> &lt; 0.0001) and children with RAP without identified organic disease (18 \u00b1 24 mg kg<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic> &lt; 0.0001).<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: Faecal calprotectin may differentiate between functional abdominal pain and IBD in school\u2010aged children. In young infants high faecal calprotectin levels are normal.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2002.tb01638.x","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T03:00:07Z","timestamp":1281150007000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and healthy 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