{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:06:41Z","timestamp":1770746801740,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":1676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>High levels of serum leptin (LPT) were reported in adult patients with sepsis and a protective role was suggested. LPT was determined in sera from 55 children with severe sepsis at admission (0 h), 6, 24 and 48 h. LPT levels were higher at 0 h than at 24 h (2.80 vs 1.61 ng\/ml; <jats:italic>p<\/jats:italic>= 0.009) and a negative correlation was found with IL\u201013 (<jats:italic>p<\/jats:italic>= 0.009), and granulocyte counts (<jats:italic>p<\/jats:italic>= 0.035), but not with other factors. Infants younger than 12 mo of age had higher LPT levels than older infants (5.88 vs 2.38 ng\/ml; <jats:italic>p<\/jats:italic>= 0.0005). The increase in LPT levels was higher in non\u2010survivor patients than in survivors, with a maximum difference at 24 h (5.30 vs 1.45 ng\/ml; <jats:italic>p<\/jats:italic>= 0.0042). However, LPT levels were not associated with shock, multiorgan failure or the severity score. Children who died showed higher percentiles of weight than survivors (<jats:italic>p<\/jats:italic>= 0.025). A subgroup with higher LPT (&lt;Pc75) included mainly patients with weight &lt;Pc50 (<jats:italic>p<\/jats:italic>= 0.0065), low IL\u201013 levels (<jats:italic>p<\/jats:italic>= 0.007) and low granulocyte counts (<jats:italic>p<\/jats:italic>= 0.013), <jats:italic>Neisseria meningitidis<\/jats:italic> B being the most frequently isolated germ (<jats:italic>p<\/jats:italic>= 0.022).<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: Using a model of severe infection, mainly meningococcal, in young children (median 3 y 6 mo old), it was not possible to confirm previous results in adults. A general protective role for LPT in sepsis seems unlikely.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2002.tb03291.x","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T22:27:00Z","timestamp":1281133620000},"page":"626-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of leptin levels and body weight in survival of children with sepsis"],"prefix":"10.1111","volume":"91","author":[{"given":"A","family":"Blanco\u2010Quir\u00f3s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Casado\u2010Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Arranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JA","family":"Garrote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Asensio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06348-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0997-1029"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.5.4952"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/314963"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.1.4610"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1997.tb00160.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119824"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118653"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978967"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198811000-00006"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)93067-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050060"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198604000-00002"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2346.1999.00535.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.4.E658"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000023306"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","article-title":"Leptin in the regulation of immunity, inflammation, and hematopoiesis","volume":"68","author":"Fantuzzi G","year":"2000","journal-title":"J Leukocyte Biol"},{"key":"e_1_2_1_19_2","first-page":"7","article-title":"Leptin and the immune system: how nutritional status influences the immune response","volume":"11","author":"Matarese G.","year":"2000","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1681\/ASN.V961074","article-title":"Inappropriate elevation of serum leptin levels in children with chronic renal failure. 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