{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:26:25Z","timestamp":1790375185480,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":1281,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p> <jats:italic>Aim<\/jats:italic>: To compare short\u2010term effects and neurodevelopmental outcome of neonatal glucocorticoid therapy between two centres. <jats:italic>Methods<\/jats:italic>: A retrospective study was performed in two centres using a tapering course of either 5 to 1 mgkg<jats:sup>\u22121<\/jats:sup> hydrocortisone (HC; 22 d) or 0.5 to 0.1 mg kg<jats:sup>\u22121<\/jats:sup> dexamethasone (DEX; 21 d). In both centres glucocorticoid\u2010treated infants and control patients were matched for gestational age, birthweight, severity of infant respiratory distress syndrome and periventricular\u2010intraventricular haemorrhage. The following short\u2010term glucocorticoid\u2010induced effects were investigated in 25 HC\u2010treated and 25 control patients in centre A, and in 23 DEX\u2010treated and 23 control patients in centre B: oxygen dependency (inspiratory oxygen fraction), arterial pressure, blood glucose and urea concentrations, weight gain and head circumference before, during and after therapy (in treated infants), or at an interval comparable to treated infants (in control infants). Neurological outcome, psychomotor development and school performance at 5\u20137 y of age was evaluated in all groups. <jats:italic>Results<\/jats:italic>: HC and DEX were equally potent in reducing oxygen dependency. Mean arterial pressure as well as blood glucose and urea concentrations were significantly increased during DEX, but not during HC treatment. Weight gain stopped during DEX therapy, but not during HC. Head circumference in both treatment groups was decreased after therapy compared with controls. Neonatally DEX \u2010treated children needed special school education significantly more often (<jats:italic>p<\/jats:italic> &lt; 0.01) than controls at 5\u20137 y of age. No differences between neonatally HC\u2010treated children and controls on neurodevelopmental outcome were found at 5\u20137 y of age.<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: Neonatal HC therapy has fewer short\u2010 and long\u2010term adverse effects than neonatal DEX therapy.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2003.tb02541.x","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T21:51:55Z","timestamp":1281131515000},"page":"827-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Short\u2010 and long\u2010term effects of neonatal glucocorticoid therapy: is hydrocortisone an alternative to dexamethasone?"],"prefix":"10.1111","volume":"92","author":[{"given":"M","family":"van der Heide\u2010Jalving","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PJGH","family":"Kamphuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJ","family":"van der Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VM","family":"Wiegant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CJ","family":"Heijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Veen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"van Bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906083202301"},{"key":"e_1_2_1_3_2","volume-title":"Cochrane Library","author":"Halliday HL","year":"2001"},{"key":"e_1_2_1_4_2","volume-title":"Cochrane Library","author":"Halliday HL","year":"2001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440203"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb13957.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.5.e7"},{"key":"e_1_2_1_8_2","first-page":"900","article-title":"Neonatal treatment with dexamethasone reduces myocardial weight in juvenile and adult rats","volume":"52","author":"Vries WB","year":"2002","journal-title":"Pediatr Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199807000-00017"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(89)90073-7"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.1.15"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.83.3.F177"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-1-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.2.413"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.6.1258"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.97.2.210"},{"key":"e_1_2_1_17_2","first-page":"1431","volume-title":"The pharmacological basis of therapeutics","author":"Haynes RC","year":"1990"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.1.55"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(87)90040-0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90210-4"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00974058"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83290-1"},{"key":"e_1_2_1_24_2","volume-title":"Examination of the child with minor neurological dysfunction","author":"Touwen BCL","year":"1979"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980228)17:4<407::AID-SIM742>3.0.CO;2-L"},{"key":"e_1_2_1_26_2","first-page":"1557","volume-title":"Endocrinology","author":"Feldman D.","year":"1998"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199805)41:5<761::AID-ART2>3.0.CO;2-M"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02463-6"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.262"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00444135"},{"key":"e_1_2_1_31_2","first-page":"299A","article-title":"Impairment of spatial learning performance and hippocampal synaptic plasticity in adult rats treated with dexamethasone in early life","volume":"49","author":"Kamphuis PJGH","year":"2002","journal-title":"Pediatr Res"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(00)00115-X"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90088-0"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.2.217"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.330"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1152\/physrev.1985.65.4.946","article-title":"Biochemical effects of corticosteroids on neuronal tissues","volume":"65","author":"Meyer JS","year":"1985","journal-title":"Physiol Rev"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1159\/000112380"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90045-7"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1425"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2003.tb02541.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2003.tb02541.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T20:26:01Z","timestamp":1700166361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2003.tb02541.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":38,"aliases":["10.1080\/08035250310002425"],"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1111\/j.1651-2227.2003.tb02541.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2003.tb02541.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7]]},"assertion":[{"value":"2007-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}