{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:35:03Z","timestamp":1774323303269,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":1250,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p> <jats:italic>Aim<\/jats:italic>: To evaluate the response rate to antimycobacterial drug therapy in patients with cystic fibrosis (CF) suffering from infection by non\u2010tuberculous mycobacteria (NTM). <jats:italic>Methods<\/jats:italic>: Ten patients, aged 10\u201334 y, out of 180 CF patients, were diagnosed with NTM disease. They had been regularly checked and examined for pulmonary symptoms, and had had chest X\u2010rays and sputum cultures (including for mycobacteria) performed. One additional 36\u2010y\u2010old female received her CF diagnosis soon after the NTM diagnosis. <jats:italic>Results<\/jats:italic>: Mycobacterium avium\u2010intracellulare complex (MAC) was found in 10 out of 11 patients and M. kansasii in 1 patient. Treatment with antimycobacterial drugs resulted in clinical improvement (weight gain or stabilization of weight and\/or improved or stabilized lung function in 8 out of 11 patients) and mycobacterial culture turned negative in 10 out of 11.<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: Promising results may be associated with early intervention with antimycobacterial therapy in CF patients.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2003.tb00623.x","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T04:31:14Z","timestamp":1281155474000},"page":"910-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Early chemotherapy for non\u2010tuberculous mycobacterial infections in patients with cystic fibrosis"],"prefix":"10.1111","volume":"92","author":[{"given":"U","family":"Forsl\u00f6w","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Geborek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Hjelte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Petrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Heurlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198909283211304"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549309008551"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.6.1381"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.45.5.397"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14b18.x"},{"key":"e_1_2_1_7_2","first-page":"272","article-title":"Non\u2010tuberculous mycobacterial pulmonary disease in cystic fibrosis","volume":"11","author":"Olivier K","year":"1996","journal-title":"Respir Infect"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.39.5.369"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.2_Supplement.146S"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511570247.002"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.11.838"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199835040-00004"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405123301904"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.35675"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199912)28:6<449::AID-PPUL11>3.0.CO;2-H"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.suppl_1.93"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00809.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/3.5.1052"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1183\/09031936.94.07020247","article-title":"Mycobacterium avium complex develop resistance to synergistically active drug combinations during infection","volume":"7","author":"Hoffner SE","year":"1994","journal-title":"Eur Respir J"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.3.167"},{"key":"e_1_2_1_21_2","first-page":"3398","article-title":"HIV\u2010negative patients with atypical pulmonary mycobacterium infection. Unfavourable prognosis for M avium infection","volume":"94","author":"Heurlin N","year":"1997","journal-title":"Lakartidningen"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.2.8756832"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.1.70"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2003.tb00623.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2003.tb00623.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:46:57Z","timestamp":1700261217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2003.tb00623.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":22,"aliases":["10.1080\/08035250310004388"],"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1111\/j.1651-2227.2003.tb00623.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2003.tb00623.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8]]},"assertion":[{"value":"2007-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}