{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:20:31Z","timestamp":1790713231123,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":1189,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p> <jats:italic>Aim<\/jats:italic>: To make a prospective assessment of close family members of patients with coeliac disease (CD) by testing their endomysium (EMA) and antigliadin antibodies once a year over a period of 12 y and to investigate whether and when they would develop a positive serology for CD while on a gluten\u2010containing diet. <jats:italic>Methods<\/jats:italic>: Since first\u2010degree relatives of CD patients have a high prevalence of CD, we screened 92 children and adolescents, all first\u2010degree relatives of coeliac patients, for EMA and total IgA antibodies, once a year. <jats:italic>Results<\/jats:italic>: Among 11 relatives, at the time of the first screening, 6 already had a positive serology and histology for CD, while 5 became positive only after a period of 2 to 5 y of negative testing. The jejunal mucosa biopsy of these five relatives with retarded positive serology for CD showed a flat mucosa in four of them and a partial villous atrophy in one. They were all HLA DQ2 positive and clinically silent for CD.<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: CD can manifest itself after years of negative serological testing.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2003.tb02475.x","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T00:41:44Z","timestamp":1281141704000},"page":"1149-1152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Onset of coeliac disease: a prospective longitudinal study"],"prefix":"10.1111","volume":"92","author":[{"given":"K","family":"Pittschieler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Gentili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Niederhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","unstructured":"PittschielerK LadinserB.Coeliac disease: screened by a new strategy.Acta P\u00e6diatr1996; Suppl 412:42\u20135.","DOI":"10.1111\/j.1651-2227.1996.tb14247.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90989-X"},{"key":"e_1_2_1_4_2","first-page":"773","article-title":"Coeliac disease in the year 2000","volume":"31","author":"Auricchio S","year":"1999","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026612121041"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.6.776"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200201000-00012"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91262-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.4.476"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.6.495"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613040"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.d01-892.x"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1651-2227.2003.tb02475.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1651-2227.2003.tb02475.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:17:43Z","timestamp":1700277463000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1651-2227.2003.tb02475.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":11,"aliases":["10.1080\/08035250310005332"],"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1111\/j.1651-2227.2003.tb02475.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1651-2227.2003.tb02475.x","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"2007-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}