{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:34:13Z","timestamp":1773282853592,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T00:00:00Z","timestamp":1167696000000},"content-version":"vor","delay-in-days":1006,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>: To investigate the distribution and antimicrobial resistance in urinary tract pathogens, primarily <jats:italic>Escherichia coli<\/jats:italic>, in two age groups, children 2 y and adults 18\u201050 y, over a period of 12 y. <jats:italic>Methods<\/jats:italic>: From the database of the microbiological laboratory all urinary tract culture data were extracted and structured according to date, patient age, bacteriological findings, antimicrobial susceptibility results and sample type. Statistical longitudinal analysis of bacteriological findings and antimicrobial resistance trends in the two age groups were performed. <jats:italic>Results<\/jats:italic>: Statistical significance was obtained for the following results. <jats:italic>Escherichia coli<\/jats:italic> was the most common pathogen in both age groups and irrespective of sample type. In <jats:italic>E. coli<\/jats:italic> resistance to ampicillin and trimethoprim was higher in children than in adults and increased over time in both age groups. Resistance to fluoroquinolones was higher in adults than in children and increased over time in both groups. Resistance to pivmecillinam, cefadroxil and nitrofurantoin was below 2% in 2001 in both age groups.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: The steadily increasing and now high <jats:italic>E. coli<\/jats:italic> resistance levels in children to ampicillin and trimethoprim render empirical therapy with these drugs doubtful. The stable and low levels of resistance to pivmecillinam, cefadroxil and nitrofurantoin (&gt;2% in 2001) make these drugs reasonable alternatives in uncomplicated lower urinary tract infections.<\/jats:p>","DOI":"10.1080\/08035250410023034","type":"journal-article","created":{"date-parts":[[2004,4,2]],"date-time":"2004-04-02T12:07:32Z","timestamp":1080907652000},"page":"487-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Antimicrobial resistance in <i>Escherichia coli<\/i> in urine samples from children and adults: a 12 year analysis"],"prefix":"10.1111","volume":"93","author":[{"given":"K Abelson","family":"Storby","sequence":"first","affiliation":[]},{"given":"A","family":"\u00d6sterlund","sequence":"additional","affiliation":[]},{"given":"G","family":"Kahlmeter","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2007,1,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.2.222"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)34213-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1985.tb10059.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb03263.x"},{"key":"e_1_2_1_6_2","unstructured":"Swedish Antimicrobial Resistance Surveillance Programmehttp:\/\/www.srga.org\/eucastwt\/WTEUCAST.htm."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg028"},{"key":"e_1_2_1_8_2","unstructured":"RunehagenR KahlmeterG.A 10\u2010year study of the consumption of quinolones trimethoprim and mecillinam in relation to the development of antimicrobial resistance in a large number of species. 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Information fr\u00e5n L\u00e4kemedelsverket;1990:1."},{"key":"e_1_2_1_15_2","first-page":"212","article-title":"\u00d6kar resistensen mot trimetoprim\u2013sulfonamid?","volume":"88","author":"Bollgren I","year":"1991","journal-title":"L\u00e4kartidningen"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","unstructured":"KahlmeterG MendayP.Cross\u2010resistance and associated resistance in 2478Escherichia colifrom the pan\u2010European ECO\u2010SENS project surveying the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections. J Anti\u2010microb Chemother2003: in press.","DOI":"10.1093\/jac\/dkg280"},{"key":"e_1_2_1_17_2","first-page":"1965","article-title":"Fluororesistens hos humanpatogena bakterier. Nu resistensutveckling hos. 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