{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:36:56Z","timestamp":1758807416761},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T00:00:00Z","timestamp":1175126400000},"content-version":"vor","delay-in-days":209,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Background:<\/jats:italic> Naloxone, a specific opiate antagonist, is widely used during neonatal resuscitation to reverse possible opiate\u2010induced respiratory depression. <jats:italic>Aim:<\/jats:italic> To determine the frequency with which naloxone is administered when resuscitation guidelines are conscientiously followed and to document any effect on respiratory morbidity. <jats:italic>Methods:<\/jats:italic> Perinatal data including naloxone administration and respiratory morbidity were collected retrospectively, and compared with prospectively collected data following the introduction of \u201cGood Practice\u201d guidelines. <jats:italic>Results:<\/jats:italic> There were 500 deliveries in the retrospective arm of the study and 1000 deliveries in the prospective arm. Although a similar proportion of women received opiates in labour in the two periods of study, there was a marked reduction in the use of naloxone when the guidelines were introduced (11% of opiate\u2010exposed deliveries compared to 0.2%). There was no significant effect on respiratory morbidity with the change in practice.<\/jats:p><jats:p> <jats:bold>Conclusion:<\/jats:bold> Naloxone is rarely needed to reverse the effects of opiates in newborn infants, and its use can be curtailed by following current resuscitation guidelines without increasing respiratory morbidity.<\/jats:p>","DOI":"10.1080\/08035250500525319","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T20:10:33Z","timestamp":1140207033000},"page":"1083-1086","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Safe reduction in administration of naloxone to newborn infants: An observational study"],"prefix":"10.1111","volume":"95","author":[{"given":"Deborah","family":"Box","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Cochran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,29]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Resuscitation of babies at birth","author":"Royal College of Paediatrics and Child Health, Royal College of Obstetrics and Gynaecology","year":"1997"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1542\/peds.65.3.667","article-title":"Naloxone use in newborns","volume":"65","author":"American Academy of Pediatrics, Committee on Drugs","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(99)00012-X"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7195.1403"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.831"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.654"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90214-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90621-1"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1980.tb01088.x"},{"key":"e_1_2_5_11_2","first-page":"484","article-title":"Naloxone dosages and route of administration for infants and children: addendum to emergency drug doses for infants and children","volume":"86","author":"American Academy of Pediatrics, Committee on Drugs","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6081.228"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.4.F308"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F08035250500525319","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/08035250500525319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T18:37:08Z","timestamp":1697395028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/08035250500525319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1080\/08035250500525319"],"URL":"https:\/\/doi.org\/10.1080\/08035250500525319","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"2007-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}