{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:18:55Z","timestamp":1783977535523,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"vor","delay-in-days":1442,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Aim<\/jats:italic>: To determine the risk factors for the acquisition of nosocomial extended\u2010spectrum \u03b2\u2010lactamase (ESBL)\u2010producing <jats:italic>Enterobacteriaceae<\/jats:italic> infection in infants hospitalized in neonatal intensive care units (NICUs) and to evaluate the therapeutic outcome of these infants.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> We retrospectively reviewed the medical records of infants with nosocomial ESBL\u2010producing <jats:italic>Enterobacteriaceae<\/jats:italic> infection hospitalized in NICUs at Chang Gung Children's Hospital in 2001. The clinical features of these infants were compared with a cohort of non\u2010ESBL\u2010producing <jats:italic>Enterobacteriaceae<\/jats:italic>\u2010infected infants during the same period. The therapeutic outcome of the infants in the ESBL group was analysed.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Seventy infants were included in this study. Thirty\u2010one infants with 34 isolates were identified in the ESBL group and 39 infants with 42 isolates in the non\u2010ESBL group. Of the parameters analysed, including gestational age, birthweight, length of hospital stay before onset, the number of antibiotics used, the duration of third\u2010generation cephalosporin usage and the number of patients receiving a third\u2010generation cephalosporin prior to the onset of infection, no significant difference was found between the two groups. The infection\u2010contributed case fatality rate was 3.0% (1 of 33) in the ESBL group, not significantly different from that in the non\u2010ESBL group (1 of 41, 2.4%). Of the 31 patients in the ESBL group, 18 were treated with a carbapenem as definitive therapy while 13 were treated with a non\u2010carbapenem antibiotic regimen. No significant difference was noted in terms of mortality rate between the two subgroups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The outcome of the infants hospitalized in the NICU with ESBL\u2010producing enterobacterial infections was not indispensably grave, even when treated with a non\u2010carbapenem antibiotic regimen. The risk factors for the acquisition of ESBL\u2010producing enterobacterial infections in these infants were not identified in this series.<\/jats:p>","DOI":"10.1080\/08035250510037704","type":"journal-article","created":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T19:48:20Z","timestamp":1132688900000},"page":"1644-1649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical features of nosocomial infections by extended\u2010spectrum \u03b2\u2010lactamase\u2010producing <i>Enterobacteriaceae<\/i> in neonatal intensive care units"],"prefix":"10.1111","volume":"94","author":[{"given":"SHUN","family":"CHIU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YHU\u2010CHERLNG","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REY\u2010IN","family":"LIEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YI\u2010HONG","family":"CHOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TZOU\u2010YIEN","family":"LIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01641355"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/514938"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.80.1.F64"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1128\/jcm.31.2.179-184.1993","article-title":"Molecular epidemiology of plasmid spread among extended broad\u2010spectrum \u03b2\u2010lactamase\u2010producing Klebsiella pneumoniae isolates in a pediatric hospital","volume":"31","author":"Bingen EH","year":"1993","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.3.529"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1128\/AAC.42.1.53","article-title":"Epidemiology and successful control of a large outbreak due to Klebsiella pneumoniae producing extended\u2010spectrum \u03b2\u2010lactamases","volume":"42","author":"Pena C","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.1066"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1577-1580.2002"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1128\/JCM.37.12.4020-4027.1999","article-title":"Bacteremia due to extended\u2010spectrum \u03b2\u2010lactamase\u2010producing Escherichia coli and Klebsiella pneumoniae in a pediatric oncology ward: clinical features and identification of different plasmids carrying both SHV\u20105 and TEM\u20101 genes","volume":"37","author":"Siu LK","year":"1999","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1481-1491.2002"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.3.799-804.2002"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.04966-0"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2002.1373"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.10.4836-4838.2003"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"e_1_2_5_17_2","volume-title":"Performance standards for antimicrobial disk susceptibility tests. 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