{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:30:44Z","timestamp":1697520644729},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"vor","delay-in-days":1442,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Neonates affected by hyperprostaglandin E<jats:sub>2<\/jats:sub> syndrome (HPS) present with severe polyuria. Both urinary losses as well as prostaglandin synthesis inhibitors may precipitate acute renal failure (ARF). <jats:italic>Aim<\/jats:italic>: Our goal was to maintain euvolaemia by replacement of urinary losses. <jats:italic>Patient<\/jats:italic>: Our patient was born prematurely with a family history typical of HPS. Urinary salt and water losses and PGE<jats:sub>2<\/jats:sub> excretion were determined in 2\u2010 to 4\u2010h intervals. Salt and water were replaced accordingly.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Within the first 48 h, urinary losses and PGE<jats:sub>2<\/jats:sub> increased continuously to 50 ml\/kg\/h and 374 ng\/h\/1.73 m<jats:sup>2<\/jats:sup>, respectively. Following exposure to 0.05\u20130.5 mg\/kg\/d indomethacin, urinary output decreased steadily to 10\u201315\/ ml\/kg\/h.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In euvolaemic preterm neonates with HPS and the need for excessive replacement of salt and water, inhibition of renal PGE<jats:sub>2<\/jats:sub> excretion with indomethacin effectively reduces polyuria and natriuresis without acutely compromising renal function.<\/jats:p>","DOI":"10.1080\/08035250510043897","type":"journal-article","created":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T19:48:20Z","timestamp":1132688900000},"page":"1690-1693","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Perinatal management of a preterm neonate affected by hyperprostaglandin E<sub>2<\/sub> syndrome (HPS)"],"prefix":"10.1111","volume":"94","author":[{"given":"MARTIN","family":"K\u00d6MHOFF","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ISMAIL","family":"TEKESIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELANIE","family":"PETERS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREAS","family":"LEONHARD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNSJ\u00d6RG W.","family":"SEYBERTH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)01086-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80395-4"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00600.2004"},{"key":"e_1_2_7_5_2","first-page":"55","article-title":"Induction of microsomal prostaglandin E2 synthase in the macula densa in children with hypokalemic salt\u2010losing tubulopathies","author":"K\u00f6mhoff M","year":"2004","journal-title":"Pediatric Res"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075811"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670100641"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670100595"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/301872"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00435.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12202.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050688"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.3.678"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200101000-00014"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1997.273.6.F994"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.1.F12"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1201-3"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F08035250510043897","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/08035250510043897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:20:39Z","timestamp":1697430039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/08035250510043897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1080\/08035250510043897"],"URL":"https:\/\/doi.org\/10.1080\/08035250510043897","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"2009-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}