{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:14:52Z","timestamp":1758824092000},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T00:00:00Z","timestamp":1175212800000},"content-version":"vor","delay-in-days":149,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Aim<\/jats:italic>: To identify factors related to indomethacin non\u2010responsiveness for patent ductus arteriosus (PDA) closure in very\u2010low\u2010birthweight (VLBW) neonates. <jats:italic>Methods<\/jats:italic>: A chart review of 107 VLBW neonates with a clinical diagnosis of PDA who received indomethacin, admitted to a tertiary neonatal intensive care unit in Toronto, Canada, was conducted (study period November 2001 to October 2003). Positive responders were those with no clinical evidence of PDA for 72 h after indomethacin. <jats:italic>Results<\/jats:italic>: Response to the first course of indomethacin was 75%, and to the second course 67% among initial responders. Higher CRIB score (OR 1.15, 95% CI 1.02\u20131.31) and early surfactant administration (OR 3.74, 95% CI 1.04\u201313.47) were associated with non\u2010responsiveness to indomethacin.<\/jats:p><jats:p> <jats:bold>Conclusion<\/jats:bold>: Indomethacin is effective for PDA closure. The response rate diminished with subsequent courses. Early surfactant and severity of illness at admission were associated with non\u2010responsiveness to indomethacin.<\/jats:p>","DOI":"10.1080\/08035250600615150","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T22:15:07Z","timestamp":1143756907000},"page":"1389-1393","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of indomethacin on closure of ductus arteriosus in very\u2010low\u2010birthweight neonates <sup>1<\/sup>"],"prefix":"10.1111","volume":"95","author":[{"given":"Sunit","family":"Godambe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandi","family":"Newby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibhuti","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakesh S.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2000.0036"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80909-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80560-4"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00303-2"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92296-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1402-z"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92557-V"},{"key":"e_1_2_5_9_2","volume-title":"The Cochrane Library, Issue 2, 2005","author":"Yost CC"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80247-3"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198903000-00020"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410203311603"},{"key":"e_1_2_5_13_2","volume-title":"The Cochrane Library, Issue 2, 2004","author":"Soll RF."},{"key":"e_1_2_5_14_2","volume-title":"The Cochrane Library, Issue 2, 2005","author":"Soll RF"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F08035250600615150","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/08035250600615150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:21:46Z","timestamp":1697430106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/08035250600615150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1080\/08035250600615150"],"URL":"https:\/\/doi.org\/10.1080\/08035250600615150","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"2007-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}