{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:59:30Z","timestamp":1790179170791,"version":"4.1.0"},"reference-count":84,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Ophthalmology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1080\/08820530902800017","type":"journal-article","created":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T04:22:59Z","timestamp":1239942179000},"page":"52-61","source":"Crossref","is-referenced-by-count":52,"title":["Review of the Ocular Angiogenesis Animal Models"],"prefix":"10.1080","volume":"24","author":[{"given":"Sandra R.","family":"Montezuma","sequence":"first","affiliation":[{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios","family":"Vavvas","sequence":"additional","affiliation":[{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan W.","family":"Miller","sequence":"additional","affiliation":[{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2009,7,2]]},"reference":[{"key":"e_1_3_1_2_1","first-page":"137","article-title":"The mode of development of the vascular system of the retina. With some observations on its significance for certain retinal diseases","volume":"68","author":"Michaelson I C","year":"1948","unstructured":"Michaelson I C. The mode of development of the vascular system of the retina. With some observations on its significance for certain retinal diseases. Trans Ophthalmol Soc UK 1948; 68: 137","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.68.1.42"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.38.7.397"},{"key":"e_1_3_1_5_1","first-page":"51","article-title":"Animal experiments in retrolental fibroplasia","volume":"58","author":"Ashton N","year":"1954","unstructured":"Ashton N. Animal experiments in retrolental fibroplasia. Trans Am Acad Ophthalmol Otolaryngol 1954; 58: 51\u20133, discussion, 53\u20134","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1954.tb15463.x"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.48.2.75"},{"key":"e_1_3_1_8_1","first-page":"91","article-title":"Experimental subretinal neovascularization","volume":"63","author":"Baum J L","year":"1965","unstructured":"Baum J L, Wise G N. Experimental subretinal neovascularization. Transactions of the American Ophthalmological Society 1965; 63: 91\u2013107","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1949.00900040416002"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(66)80004-0"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.2.261"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/52.2.413"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240290402"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2432664"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.368"},{"key":"e_1_3_1_16_1","first-page":"597","article-title":"Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels","volume":"79","author":"Ausprunk D H","year":"1975","unstructured":"Ausprunk D H, Knighton D R, Folkman J. Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. Am J Pathol 1975; 79: 597\u2013618","journal-title":"Am J Pathol"},{"key":"e_1_3_1_17_1","first-page":"2109","article-title":"Tumor angiogenesis factor","volume":"34","author":"Folkman J","year":"1974","unstructured":"Folkman J. Tumor angiogenesis factor. Cancer Res 1974; 34: 2109\u20132113","journal-title":"Cancer Res"},{"key":"e_1_3_1_18_1","first-page":"707","article-title":"The development of an experimental model of subretinal neovascularization in disciform macular degeneration","volume":"77","author":"Ryan S J","year":"1979","unstructured":"Ryan S J. The development of an experimental model of subretinal neovascularization in disciform macular degeneration. Trans Am Ophthalmol Soc 1979; 77: 707\u2013745","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040784015"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090060145039"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100060136048"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030030333024"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00159839"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00159840"},{"key":"e_1_3_1_25_1","first-page":"574","article-title":"Vascular endothelial growth factor\/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model","volume":"145","author":"Miller J W","year":"1994","unstructured":"Miller J W, Adamis A P, Shima D T, et al. Vascular endothelial growth factor\/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol 1994; 145: 574\u2013584","journal-title":"Am J Pathol"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.905"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00941723"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140419009"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.1999.13.2.65"},{"key":"e_1_3_1_30_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.1.26.5116"},{"key":"e_1_3_1_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1996.tb00994.x"},{"key":"e_1_3_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(69)80083-7"},{"key":"e_1_3_1_33_1","first-page":"1625","article-title":"A model of angiogenesis in the mouse cornea","volume":"37","author":"Kenyon B M","year":"1996","unstructured":"Kenyon B M, Voest E E, Chen C C, Flynn E, Folkman J, D'Amato R J. A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci 1996; 37: 1625\u20131632","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1996.tb01596.x"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070020575043"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198503000-00004"},{"key":"e_1_3_1_37_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0695"},{"key":"e_1_3_1_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200307000-00013"},{"key":"e_1_3_1_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2007.01572.x"},{"key":"e_1_3_1_40_1","first-page":"264","article-title":"Corneal angiogenic privilege: Angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis)","volume":"104","author":"Azar D T","year":"2006","unstructured":"Azar D T. Corneal angiogenic privilege: Angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 2006; 104: 264\u2013302","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_3_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64643-3"},{"key":"e_1_3_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(75)90073-2"},{"key":"e_1_3_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90483-9"},{"key":"e_1_3_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(81)90281-6"},{"key":"e_1_3_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(81)90230-0"},{"key":"e_1_3_1_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199111020-00010"},{"key":"e_1_3_1_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070010270035"},{"key":"e_1_3_1_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688908997565"},{"key":"e_1_3_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65753-7"},{"key":"e_1_3_1_50_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1194"},{"key":"e_1_3_1_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01127.x"},{"key":"e_1_3_1_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.3.338"},{"key":"e_1_3_1_53_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8422com"},{"key":"e_1_3_1_54_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1993.1042"},{"key":"e_1_3_1_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0518-9"},{"key":"e_1_3_1_56_1","first-page":"2110","article-title":"A new model of subretinal neovascularization in the rabbit","volume":"36","author":"Kimura H","year":"1995","unstructured":"Kimura H, Sakamoto T, Hinton D R, et al. A new model of subretinal neovascularization in the rabbit. Investigative Ophthalmology & Visual Science 1995; 36: 2110\u20132119","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_3_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.01.027"},{"key":"e_1_3_1_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172759"},{"key":"e_1_3_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.11.014"},{"key":"e_1_3_1_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000136903"},{"key":"e_1_3_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75913-6"},{"key":"e_1_3_1_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01681698"},{"key":"e_1_3_1_63_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.857"},{"key":"e_1_3_1_64_1","first-page":"281","article-title":"Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization","volume":"151","author":"Okamoto N","year":"1997","unstructured":"Okamoto N, Tobe T, Hackett S F, et al. Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization. Am J Pathol 1997; 151: 281\u2013291","journal-title":"Am J Pathol"},{"key":"e_1_3_1_65_1","first-page":"13","article-title":"Vascular endothelial growth factor and ocular neovascularization","volume":"151","author":"Miller J W","year":"1997","unstructured":"Miller J W. Vascular endothelial growth factor and ocular neovascularization. Am J Pathol 1997; 151: 13\u201323","journal-title":"Am J Pathol"},{"key":"e_1_3_1_66_1","first-page":"180","article-title":"Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors","volume":"39","author":"Tobe T","year":"1998","unstructured":"Tobe T, Okamoto N, Vinores M A, et al. Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors. Invest Ophthalmol Vis Sci 1998; 39: 180\u2013188","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64891-2"},{"key":"e_1_3_1_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.059089"},{"key":"e_1_3_1_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02482606"},{"key":"e_1_3_1_70_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.7.725.5054"},{"key":"e_1_3_1_71_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689608995831"},{"key":"e_1_3_1_72_1","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith L E","year":"1994","unstructured":"Smith L E, Wesolowski E, Mclellan A, et al. Oxygen-induced retinopathy in the mouse. Investigative Ophthalmology & Visual Science 1994; 35: 101\u2013111","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_3_1_73_1","first-page":"222","article-title":"Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice","volume":"42","author":"Brooks S E","year":"2001","unstructured":"Brooks S E, Gu X, Samuel S, et al. Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice. Investigative Ophthalmology & Visual Science 2001; 42: 222\u2013228","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_3_1_74_1","first-page":"300","article-title":"Vaso-obliteration in the canine model of oxygen-induced retinopathy","volume":"37","author":"McLeod D S","year":"1996","unstructured":"McLeod D S, Brownstein R, Lutty G A. Vaso-obliteration in the canine model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 1996; 37: 300\u2013311","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002748"},{"key":"e_1_3_1_76_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1003"},{"key":"e_1_3_1_77_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.17.5.294"},{"key":"e_1_3_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74395-8"},{"key":"e_1_3_1_79_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.133.2.275"},{"key":"e_1_3_1_80_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724080-00003"},{"key":"e_1_3_1_81_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.58.061705.145635"},{"key":"e_1_3_1_82_1","first-page":"401","article-title":"Potential future targets for treating ocular neovascularization","volume":"19","author":"Barouch F C","year":"2006","unstructured":"Barouch F C, Miller J W. Potential future targets for treating ocular neovascularization. Ophthalmol Clin North Am 2006; 19: 401\u2013409","journal-title":"Ophthalmol Clin North Am"},{"key":"e_1_3_1_83_1","first-page":"1574","article-title":"Expression of pigment epithelium-derived factor in experimental choroidal neovascularization","volume":"43","author":"Renno R Z","year":"2002","unstructured":"Renno R Z, Youssri A I, Michaud N, Gragoudas E S, Miller J W. Expression of pigment epithelium-derived factor in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 2002; 43: 1574\u20131580","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_84_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0087"},{"key":"e_1_3_1_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.4.509"}],"container-title":["Seminars in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/08820530902800017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:15:21Z","timestamp":1753100121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/08820530902800017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1080\/08820530902800017"],"URL":"https:\/\/doi.org\/10.1080\/08820530902800017","relation":{},"ISSN":["0882-0538","1744-5205"],"issn-type":[{"value":"0882-0538","type":"print"},{"value":"1744-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}