{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:51:09Z","timestamp":1790254269850,"version":"4.1.0"},"reference-count":36,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Ophthalmology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1080\/08820530902800108","type":"journal-article","created":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T04:23:01Z","timestamp":1239942181000},"page":"70-76","source":"Crossref","is-referenced-by-count":33,"title":["Prospects for Treatment of Pediatric Vitreoretinal Diseases with Vascular Endothelial Growth Factor Inhibition"],"prefix":"10.1080","volume":"24","author":[{"given":"Kristie L.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold J.","family":"Kroll","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2009,7,2]]},"reference":[{"key":"e_1_3_1_2_1","first-page":"1217","article-title":"Vascularization of the human fetal retina: Roles of vasculogenesis and angiogenesis","volume":"41","author":"Hughes S","year":"2000","unstructured":"Hughes S, Yang H, Chan-Ling T. Vascularization of the human fetal retina: Roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci 2000; 41: 1217\u20131228","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.098426"},{"key":"e_1_3_1_4_1","first-page":"353","article-title":"Vascular endothelial growth factor localization in human ovary and fallopian tubes: Possible role in reproductive function and ovarian cyst formation","volume":"81","author":"Gordon J D","year":"1996","unstructured":"Gordon J D, Mesiano S, Zaloudek C J, Jaffe R B. Vascular endothelial growth factor localization in human ovary and fallopian tubes: Possible role in reproductive function and ovarian cyst formation. J Clin Endocrinol Metab 1996; 81: 353\u2013359","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823562"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2479986"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-1891(03)00011-9"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000102937.50486.1B"},{"key":"e_1_3_1_10_1","first-page":"99","article-title":"Upregulation of vascular endothelial growth factor in ischemic and no-ischemic human and experimental retinal disease","volume":"12","author":"Vinores S A","year":"1997","unstructured":"Vinores S A, Youssri A L, Luna J D. Upregulation of vascular endothelial growth factor in ischemic and no-ischemic human and experimental retinal disease. Histol Histopathol 1997; 12: 99\u2013109","journal-title":"Histol Histopathol"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.1.4.467"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-02598-0.50086-0"},{"key":"e_1_3_1_13_1","first-page":"576","article-title":"Variable oxygen exposure causes preretinal neovascularization in the newborn rat","volume":"34","author":"Penn J S","year":"1993","unstructured":"Penn J S, Tolman B L, Lowery L A. Variable oxygen exposure causes preretinal neovascularization in the newborn rat. Invest Ophthalmol Vis Sci 1993; 34: 576\u2013585","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00424.2002"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1095-1024"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140419009"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65004-3"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.08.050"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318159ec6b"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318177f934"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/380435a0"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2008.1"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.017"},{"key":"e_1_3_1_24_1","first-page":"626","article-title":"VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice","volume":"12","author":"Konopatskaya O","year":"2006","unstructured":"Konopatskaya O, Churchill A J, Harper S J, Bates D O, Gardiner T A. VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice. Mol Vis 2006; 12: 626\u2013632","journal-title":"Mol Vis"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181679bf6"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(69)91237-9"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0360"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945008784911822"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-008-9095-3"},{"key":"e_1_3_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0786-7"},{"key":"e_1_3_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0949-6"},{"key":"e_1_3_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-02598-0.50083-5"},{"key":"e_1_3_1_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820530701420082"},{"key":"e_1_3_1_34_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2008.22.3.190"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2008.01.009"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-02598-0.50151-8"},{"key":"e_1_3_1_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003554"}],"container-title":["Seminars in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/08820530902800108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:15:25Z","timestamp":1753100125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/08820530902800108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1080\/08820530902800108"],"URL":"https:\/\/doi.org\/10.1080\/08820530902800108","relation":{},"ISSN":["0882-0538","1744-5205"],"issn-type":[{"value":"0882-0538","type":"print"},{"value":"1744-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}