{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:19:49Z","timestamp":1779218389943,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Abuse"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Background: Ending homelessness is a major priority of the Department of Veteran Affairs (VA), and alcohol use can be a barrier to stable housing. Clinical trials suggest that depot extended-release naltrexone (XR-NTX) is efficacious in reducing alcohol consumption among alcohol-dependent subjects. Methods: An open-label, randomized pilot study sought to examine the feasibility and effectiveness of XR-NTX versus oral naltrexone to improve alcohol consumption and housing stability among homeless, alcohol-dependent veterans at the Providence Veteran Affairs Medical Center. Results: Of 215 potential candidates approached over a 16-month recruitment period, only 15 agreed to consider study entry and 7 were randomized. The primary reasons given for refusal were not wanting an injection; fear of needles; and not wanting to change drinking habits. Only 1 participant in the XR-NTX group returned after the first injection. Three participants in the oral naltrexone group attended all 7 visits and had good outcomes. Conclusions: Although XR-NTX has demonstrated efficacy in reducing heavy drinking, limited acceptance of the injection might reduce its effectiveness among homeless, alcohol-dependent patients.<\/jats:p>","DOI":"10.1080\/08897077.2012.763083","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T15:57:44Z","timestamp":1357833464000},"page":"94-96","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Aversion to Injection Limits Acceptability of Extended-Release Naltrexone among Homeless, Alcohol-Dependent Patients"],"prefix":"10.1177","volume":"34","author":[{"given":"Peter D.","family":"Friedmann","sequence":"first","affiliation":[{"name":"Center on System, Outcomes & Quality in Chronic Disease & Rehabilitation, Research Service, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"},{"name":"Department of Medicine, Alpert Medical School, Brown University, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Mello","sequence":"additional","affiliation":[{"name":"Center on System, Outcomes & Quality in Chronic Disease & Rehabilitation, Research Service, and Homeless Patient-Aligned Care Team, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Lonergan","sequence":"additional","affiliation":[{"name":"Center on System, Outcomes & Quality in Chronic Disease & Rehabilitation, Research Service, and Homeless Patient-Aligned Care Team, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Bourgault","sequence":"additional","affiliation":[{"name":"Center on System, Outcomes & Quality in Chronic Disease & Rehabilitation, Research Service, and Homeless Patient-Aligned Care Team, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"O'Toole","sequence":"additional","affiliation":[{"name":"Center on System, Outcomes & Quality in Chronic Disease & Rehabilitation, Research Service, and Homeless Patient-Aligned Care Team, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA"},{"name":"Alpert Medical School, Brown University, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"bibr1-08897077.2012.763083","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2003.21209.x"},{"key":"bibr2-08897077.2012.763083","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1041350"},{"key":"bibr3-08897077.2012.763083","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1617"},{"key":"bibr4-08897077.2012.763083","unstructured":"U.S. Department of Housing and Urban Development. The Homeless Emergency Assistance and Rapid Transition to Housing (HEARTH) Act of 2009. Available at: http:\/\/www.hudhre.info\/documents\/Homel-essAssistanceActAmendedbyHEARTH.pdf. Accessed November 27, 2012"},{"key":"bibr5-08897077.2012.763083","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.64.5.881"},{"key":"bibr6-08897077.2012.763083","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2009.179416"},{"key":"bibr7-08897077.2012.763083","doi-asserted-by":"publisher","DOI":"10.1300\/J069v19n01_06"},{"key":"bibr8-08897077.2012.763083","first-page":"77","volume":"12","author":"Sobell L","year":"1990","journal-title":"Behav Assess"},{"key":"bibr9-08897077.2012.763083","author":"Publicker M R","journal-title":"Presented at Workshop C2: Extended-Release Naltrexone (XR-NTX) in General Medical and Psychiatric Settings, 20th Annual Meeting of the American Association of Addiction Psychiatry; Los Angeles, CA"},{"key":"bibr10-08897077.2012.763083","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.341"},{"key":"bibr11-08897077.2012.763083","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.01150.x"},{"key":"bibr12-08897077.2012.763083","first-page":"172","volume":"30","author":"Wright S","year":"2009","journal-title":"Aust Fam Physician"}],"container-title":["Substance Abuse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/08897077.2012.763083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1080\/08897077.2012.763083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/08897077.2012.763083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:43:41Z","timestamp":1777625021000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1080\/08897077.2012.763083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1080\/08897077.2012.763083"],"URL":"https:\/\/doi.org\/10.1080\/08897077.2012.763083","relation":{},"ISSN":["0889-7077","1547-0164"],"issn-type":[{"value":"0889-7077","type":"print"},{"value":"1547-0164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}