{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:31:09Z","timestamp":1783981869924,"version":"3.55.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Abuse"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The link between nasal inhalation of cocaine and nasal and palatal necrosis is well documented. In contrast, few data are available concerning nasal mucosa necrosis related to heroin snorting. The authors report here the retrospective analysis of 24 cases of orofacial lesions in patients with nasal heroin usage, collected between 2006 and 2012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"cases\">\n                    <jats:title>Cases<\/jats:title>\n                    <jats:p>The cases concern 17 males and 7 females (median age 29.5 (range: 24\u201342)) with chronic consumption of intranasal heroin (from 2 months to more than 10\u00a0years). Six patients had a history of cocaine abuse. The median daily amount of heroin consumption was 5\u00a0g (range: 0.5\u201310). The complications were nasal perforation (11 cases), nasal ulceration or erythema (5 cases), nasal septum necrosis (5 cases), pharyngeal ulceration (3 cases), and palate damages (5 cases). The most common clinical signs and symptoms were nasal pain, purulent sputum, dysphagia, and rhinitis. Maintenance therapy with methadone (19 cases) or buprenorphine (3 cases) was initiated. In 8 cases, the injury improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"discussion\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The potential of heroin to induce destructive orofacial lesions should be considered when nasal damages are observed in patients with drug abuse. A multidisciplinary approach seems to be the most effective means of managing such patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1080\/08897077.2013.781565","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T12:03:56Z","timestamp":1363781036000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Necrosis of the Intranasal Structures and Soft Palate as a Result of Heroin Snorting: A Case Series"],"prefix":"10.1177","volume":"34","author":[{"given":"H\u00e9l\u00e8ne","family":"Peyri\u00e8re","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale et Toxicologie, Centre d'Addictovigilance, Centre Hospitalier Universitaire, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"L\u00e9glise","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Traitement des Toxicod\u00e9pendances, M\u00e9decine Interne E, Centre Hospitalier Universitaire, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Rousseau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie Maxillo-faciale, Centre Hospitalier Universitaire, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Cartier","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oto-Rhino-Laryngologie, Centre Hospitalier Universitaire, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Gibaja","sequence":"additional","affiliation":[{"name":"Centre d'Addictovigilance, Centre Hospitalier Universitaire, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Galland","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Traitement des Addictions, Centre Hospitalier B\u00e9ziers, B\u00e9ziers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050711"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2012064"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050120000013"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2007.03.015"},{"key":"e_1_3_1_6_1","first-page":"15","article-title":"Le syst\u00e8me fran\u00e7ais d\u2019\u00e9valuation de la pharmacod\u00e9pendance et de l'abus: cons\u00e9cration juridique","volume":"56","author":"Baumevieille M","year":"2001","unstructured":"Baumevieille M, , Miremont G, and Haramburu F. 2001. Le syst\u00e8me fran\u00e7ais d\u2019\u00e9valuation de la pharmacod\u00e9pendance et de l'abus: cons\u00e9cration juridique. 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Vasoconstriction potency induced by aminoamide local anesthetics correlates with lipid solubility. J Biomed Biotechnol., : 2012 doi:10.1155\/2012\/170958","journal-title":"J Biomed Biotechnol."}],"container-title":["Substance Abuse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/08897077.2013.781565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1080\/08897077.2013.781565","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/08897077.2013.781565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:43:54Z","timestamp":1777625034000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1080\/08897077.2013.781565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1080\/08897077.2013.781565"],"URL":"https:\/\/doi.org\/10.1080\/08897077.2013.781565","relation":{},"ISSN":["0889-7077","1547-0164"],"issn-type":[{"value":"0889-7077","type":"print"},{"value":"1547-0164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}