{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:16:54Z","timestamp":1777897014366,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Abuse"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aims of this study were to evaluate a combination of aripiprazole and topiramate in the treatment of opioid-dependent patients with schizoaffective disorder undergoing methadone maintenance therapy (MMT) and, further, to taper off patients from methadone treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty patients who met DSM-IV (\n                      <jats:italic toggle=\"yes\">Diagnostic and Statistical Manual of Mental Disorders<\/jats:italic>\n                      , Fourth Edition) criteria for opioid dependence and schizoaffective disorder receiving MMT (80\u00a0mg\/day) were given aripiprazole (10\u00a0mg\/day) plus topiramate (up to 200\u00a0mg\/day) for 8 weeks. A methadone dose reduction of 3\u00a0mg\/day until suspension at week 4 was established.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Aripiprazole plus topiramate was effective in reducing clinical symptoms, and a rapid tapering off of MMT was achieved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combining aripiprazole and topiramate may be effective in patients with a dual diagnosis of opioid dependency and schizoaffective disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1080\/08897077.2013.814615","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T15:12:44Z","timestamp":1372173164000},"page":"119-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Aripiprazole plus Topiramate in Opioid-Dependent Patients with Schizoaffective Disorder: An 8-Week, Open-Label, Uncontrolled, Preliminary Study"],"prefix":"10.1177","volume":"35","author":[{"given":"Antonio","family":"Bruno","sequence":"first","affiliation":[{"name":"Section of Psychiatry, Department of Neurosciences, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo M.","family":"Romeo","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Neurosciences, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Pandolfo","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Neurosciences, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Scimeca","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Neurosciences, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco A.","family":"Zoccali","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Neurosciences, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosaria A.","family":"Muscatello","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Neurosciences, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"e_1_3_2_2_1","first-page":"95","article-title":"Comparative study of substance dependence comorbidity in bipolar, schizophrenic and schizoaffective disorders","volume":"22","author":"Verdoux H","year":"1996","unstructured":"Verdoux H, Mury M, Besan\u00e7on G, Bourgeois M. 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