{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:52:13Z","timestamp":1784332333391,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Abuse"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interim methadone treatment (i.e., temporary medication-only treatment) has been tested in a few U.S. studies as a method for facilitated referral to and initiation of opioid maintenance treatment in heroin dependence. However, despite the favorable safety profile of buprenorphine compared with methadone, interim treatment with buprenorphine rarely has been tested and reported in the scientific literature. The present pilot effectiveness study aims to assess the feasibility of an interim buprenorphine treatment for initiation of individuals with opiate dependence into full-scale opioid maintenance treatment, and to study baseline predictors of successful transfer to full-scale treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Interim treatment was introduced in a high-threshold setting with waiting lists to opioid maintenance treatment. Consecutive patients on the waiting list were offered the option to enter interim treatment. The interim program was a medication-only condition with supervised daily doses of buprenorphine-naloxone. The main outcome was successful transfer to full-scale opioid maintenance treatment, which required a drug-free urine sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-four patients entered interim buprenorphine treatment. Among them, 57% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 25) were successfully transferred to full-scale treatment after an average of 44 days. Remaining patients could not be transferred, generally because they did not manage to become drug-free. Successful transfer to full-scale treatment was associated with a lower baseline Alcohol Use Disorders Identification Test (AUDIT) score (4.4 vs. 12.6;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and tended to be associated with lower cannabis use (5.2 vs. 10.4 days during the past 30 days;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .06) and lower heroin use (7.2 vs. 9.9 days;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .09) prior to baseline. In a logistic regression analysis, only lower AUDIT score predicted successful treatment entry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>According to these pilot data, supervised buprenorphine-naloxone in a medication-only interim treatment condition appears to be a feasible way to improve treatment initiation in a high-threshold setting. Polydrug use, including higher levels of alcohol consumption, may predict a more complicated course in interim treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1080\/08897077.2015.1065541","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T17:55:27Z","timestamp":1436982927000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Interim Buprenorphine Treatment in Opiate Dependence: A Pilot Effectiveness Study"],"prefix":"10.1177","volume":"37","author":[{"given":"Tove","family":"Abrahamsson","sequence":"first","affiliation":[{"name":"Division of Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Widinghoff","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lilliebladh","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Gedeon","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden"},{"name":"Department of Psychiatry Lund, Psychiatry Skane, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Nilvall","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Lund, Psychiatry Skane, Lund, Sweden"},{"name":"Helsingborg General Hospital, Helsingborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Hakansson","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.13.1689"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03140.x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(95)01205-2"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.9422216.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1990.tb03057.x"},{"key":"e_1_3_4_7_2","first-page":"CD002207","article-title":"Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence","volume":"2","author":"Mattick RP","year":"2008","unstructured":"Mattick RP, , Kimber J, , Breen C, , Davoli M. 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Socialstyrelsens f\u00f6reskrifter och allm\u00e4nna r\u00e5d om l\u00e4kemedelsassisterad behandling vid opiatberoende [The Board's provisions and general guidelines on medication-assisted treatment in opiate dependence]. SOSFS 2009:27 ed. V\u00e4ster\u00e5s, Sweden: The National Board of Health and Welfare; 2009.","edition":"27"},{"key":"e_1_3_4_20_2","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Legal frameworks of opioid substitution treatment. Available at: http:\/\/www.emcdda.europa.eu\/html.cfm\/index41823EN.html. Published 2008. Accessed 2015."},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.02999.x"},{"key":"e_1_3_4_22_2","volume-title":"Survey of medication-assisted treatment in opiate dependence","author":"The National Board of Health and Welfare (Socialstyrelsen)","year":"2012","unstructured":"The National Board of Health and Welfare (Socialstyrelsen). 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