{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:37:08Z","timestamp":1784302628512,"version":"3.55.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Abuse"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In response to the opioid epidemic and new guidelines, many patients on high-dose long term opioid therapy (LTOT) for chronic pain are getting tapered off opioids. As a result, a unique clinical challenge is emerging: while many on LTOT have poor pain control, functional decline, psychiatric instability, aberrancies and misuse, these issues may often worsen with opioid tapering. Currently, a clear explanation and practical guidance on how to manage this perplexing clinical scenario is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We offer a commentary with our perspective on possible mechanisms involved in this clinical phenomena and offer practical management guidance, supported by available evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>It is not well recognized that allostatic opponent process involved in development of opioid dependence can cause worsening pain, functional status, sleep and psychiatric symptoms over time, and significant fluctuation of pain and other affective symptoms due to their bidirectional dynamic interaction with opioid dependence (\u2018affective dynamism\u2019). These elements of complex persistent dependence (CPD), the grey area between simple dependence and addiction, can lead to escalating and labile opioid need, often generating aberrant behaviors. Opioid tapering, a seemingly logical intervention in this situation, may lead to worsening of pain, function and psychiatric symptoms due to development of protracted abstinence syndrome. We offer practicing clinicians management principles and practical guidance focused on management of CPD in addition to chronic pain in these difficult clinical scenarios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Awareness of the science of the neuroplasticity effects of repeated use of opioids is necessary to better manage these patients with complex challenges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1080\/08897077.2017.1381663","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T11:49:42Z","timestamp":1505908182000},"page":"152-161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":82,"title":["The Conundrum of Opioid Tapering in Long-Term Opioid Therapy for Chronic Pain: A Commentary"],"prefix":"10.1177","volume":"39","author":[{"given":"Ajay","family":"Manhapra","sequence":"first","affiliation":[{"name":"VA New England Mental Illness Research and Education Center, West Haven, Connecticut, USA"},{"name":"Advanced Pact Pain Clinic, VA Hampton Medical Center, Hampton, Virginia, USA"},{"name":"Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Arias","sequence":"additional","affiliation":[{"name":"VA New England Mental Illness Research and Education Center, West Haven, Connecticut, USA"},{"name":"Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,4,1]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6501e1"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2009.03.021"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000537"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2015.1129526"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10251"},{"key":"e_1_3_4_7_1","volume-title":"Psychological methods of pain control: basic science and clinical perspectives","author":"Riley JL","year":"2004","unstructured":"Riley JL, , Wade JB. 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