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They face significant harm from both the pandemic itself and its social and economic consequences, including marginalization in health care and social systems. Hence, we discuss: (1) why persons with substance use disorders are at increased risk for infection with COVID-19 and a severe illness course; (2) anticipated adverse consequences of COVID-19 in persons with substance use disorders; (3) challenges to health care delivery and substance use treatment programs during and after the COVID-19 pandemic; and (4) the potential impact on clinical research in substance use disorders. We offer recommendations for clinical, public health, and social policies to mitigate these challenges and to prevent negative outcomes.<\/jats:p>","DOI":"10.1080\/08897077.2020.1784363","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T11:55:59Z","timestamp":1595418959000},"page":"286-291","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":102,"title":["Covid-19 and Persons with Substance Use Disorders: Inequities and Mitigation Strategies"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9663-2226","authenticated-orcid":false,"given":"Osnat C.","family":"Melamed","sequence":"first","affiliation":[{"name":"Addictions Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada;"},{"name":"Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya S.","family":"Hauck","sequence":"additional","affiliation":[{"name":"Addictions Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada;"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Buckley","sequence":"additional","affiliation":[{"name":"Addictions Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada;"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-2996","authenticated-orcid":false,"given":"Peter","family":"Selby","sequence":"additional","affiliation":[{"name":"Addictions Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada;"},{"name":"Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada;"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada;"},{"name":"Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Addictions Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada;"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1090"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/M20-1212"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2020.04.010"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa051"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30090-0"},{"key":"e_1_3_1_7_2","unstructured":"American Society of Addiction Medicine. 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