{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:22:51Z","timestamp":1777897371672,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA021335"],"award-info":[{"award-number":["R01AA021335"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute on Drug Abuse (NIDA) INVEST\/Clinical Trials Network"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Abuse"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Background: While associations between cannabis and cocaine use, and heavy drinking and quality of life (QOL), are well-established in the general population, it is unclear whether they are present in hospital inpatients with alcohol use disorder (AUD). The aim of the study was to assess associations between cannabis and cocaine use and two outcomes [heavy drinking days (HDDs) and QOL] among hospital inpatients with AUD. Methods: Hospitalized patients with AUD and at least one past-month HDD participated in this cross-sectional study. Cannabis and cocaine use were assessed using the Alcohol, Smoking, and Substance Involvement Screening Test. HDDs were assessed using the Timeline Followback. QOL was assessed by the WHOQOL\u2013BREF instrument. Multivariable regression models assessed associations. Results: Of 248 participants, 225 (91%) had severe AUD. There were no statistically significant associations between: recent cannabis use and HDDs [Incidence Rate Ratio (IRR) = 0.95; 95% Confidence Interval (95% CI): 0.80, 1.14], cocaine use and HDDs [IRR = 0.88; 95% CI: 0.66, 1.18], or both cannabis and cocaine use and HDDs [IRR = 0.87; 95%CI: 0.70, 1.09], as compared to use of neither cannabis nor cocaine. Use of cannabis, cocaine, and both, were not associated with QOL [(odds ratio (OR) = 0.98; 95% CI:0.55, 1.74), (OR = 0.76; 95% CI:0.30, 1.93), (OR = 1.00; 95%CI: 0.49, 2.03), respectively]. Conclusions: Among hospital inpatients with AUD, there were no significant associations between cannabis and cocaine use, heavy drinking, or QOL. Our findings raise questions regarding how drug use affects AUD and whether similar results would be found among those with milder AUD and in prospective studies.<\/jats:p>","DOI":"10.1080\/08897077.2022.2074592","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T10:55:23Z","timestamp":1654599323000},"page":"1225-1230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cannabis and Cocaine Use, Drinking Outcomes, and Quality of Life in General Hospital Inpatients with Alcohol use Disorder"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-3845","authenticated-orcid":false,"given":"Esperanza","family":"Romero-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA"},{"name":"Section of General Internal Medicine, Department of Medicine, Clinical Addiction Research and Education (CARE) Unit, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara A.","family":"Chen","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Dukes","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlin","family":"Hartlage","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor P.","family":"Palfai","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara M.","family":"Magane","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-3400","authenticated-orcid":false,"given":"Jeffrey H.","family":"Samet","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA"},{"name":"Section of General Internal Medicine, Department of Medicine, Clinical Addiction Research and Education (CARE) Unit, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA"},{"name":"Grayken Center for Addiction, Boston Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Saitz","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA"},{"name":"Section of General Internal Medicine, Department of Medicine, Clinical Addiction Research and Education (CARE) Unit, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA"},{"name":"Grayken Center for Addiction, Boston Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"bibr1-08897077.2022.2074592","unstructured":"SAMHSA, Center for Behavioral Health Statistics, Quality.\n                      Results from the 2018 National Survey on Drug Use and Health: Detailed Tables\n                      . Samhsa.gov. https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/cbhsq-reports\/NSDUHDetailedTabs2018R2\/NSDUHDetTabsSect5pe2018.htm. Accessed January 31, 2021."},{"key":"bibr2-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.06.008"},{"key":"bibr3-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.08.014"},{"key":"bibr4-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.7.749"},{"key":"bibr5-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03330.x"},{"key":"bibr6-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12698"},{"key":"bibr7-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000266"},{"key":"bibr8-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2005.03.009"},{"key":"bibr9-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0584"},{"key":"bibr10-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.01.014"},{"key":"bibr11-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1111\/add.13693"},{"key":"bibr12-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.17711\/SM.0185-3325.2014.045"},{"key":"bibr13-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12486"},{"issue":"2","key":"bibr14-08897077.2022.2074592","first-page":"148","volume":"31","author":"Arnaout B","year":"2008","journal-title":"Alcohol Res Health."},{"key":"bibr15-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1631-4"},{"key":"bibr16-08897077.2022.2074592","unstructured":"Alcohol Disorder hOsPital Treatment Trial \u2013 Full Text View \u2013 ClinicalTrials.Gov. Clinicaltrials.gov. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02478489. Accessed January 31, 2021."},{"key":"bibr17-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(97)01332-X"},{"key":"bibr18-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2011.11.025"},{"key":"bibr19-08897077.2022.2074592","unstructured":"WHOQOL \u2013 measuring Quality of life. Who.int. http:\/\/www.who.int\/mental_health\/publications\/whoqol\/en\/. Accessed January 31, 2021."},{"key":"bibr20-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2005.66.433"},{"key":"bibr21-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2007.02114.x"},{"key":"bibr22-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1081\/ADA-120002980"},{"key":"bibr23-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2016.1176613"},{"key":"bibr24-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh260"},{"key":"bibr25-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.3229"},{"issue":"1","key":"bibr26-08897077.2022.2074592","first-page":"44","volume":"6","author":"Laudet AB.","year":"2011","journal-title":"Addict Sci Clin Pract."},{"key":"bibr27-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2015.06.041"},{"key":"bibr28-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.3109\/10826084.2010.501675"},{"key":"bibr29-08897077.2022.2074592","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-019-0690-3"}],"container-title":["Substance Abuse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/08897077.2022.2074592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1080\/08897077.2022.2074592","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/08897077.2022.2074592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:56:45Z","timestamp":1777625805000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1080\/08897077.2022.2074592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1080\/08897077.2022.2074592"],"URL":"https:\/\/doi.org\/10.1080\/08897077.2022.2074592","relation":{},"ISSN":["0889-7077","1547-0164"],"issn-type":[{"value":"0889-7077","type":"print"},{"value":"1547-0164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,1]]}}}