{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:09:45Z","timestamp":1785539385710,"version":"3.56.0"},"reference-count":31,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Immunopharmacology and Immunotoxicology"],"published-print":{"date-parts":[[2019,1,2]]},"DOI":"10.1080\/08923973.2019.1566358","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T09:39:27Z","timestamp":1549877967000},"page":"130-139","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Protective effect of a topical sunscreen formulation fortified with melatonin against UV-induced photodermatitis: an immunomodulatory effect via NF-\u03baB suppression"],"prefix":"10.1080","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8648-0823","authenticated-orcid":false,"given":"Nilutpal Sharma","family":"Bora","sequence":"first","affiliation":[{"name":"Division of Pharmaceutical Technology, Defence Research Laboratory","place":["Tezpur, India"]},{"name":"Department of Pharmaceutical Sciences, Dibrugarh University","place":["Dibrugarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Dibrugarh University","place":["Dibrugarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-8370","authenticated-orcid":false,"given":"Santa","family":"Mandal","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Technology, Defence Research Laboratory","place":["Tezpur, India"]},{"name":"School of Pharmaceutical Sciences, IFTM University","place":["Moradabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangchen D.","family":"Bhutia","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Technology, Defence Research Laboratory","place":["Tezpur, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghita","family":"Das","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Technology, Defence Research Laboratory","place":["Tezpur, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Technology, Defence Research Laboratory","place":["Tezpur, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-6341","authenticated-orcid":false,"given":"Pronobesh","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Technology, Defence Research Laboratory","place":["Tezpur, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjai K.","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Technology, Defence Research Laboratory","place":["Tezpur, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.biopha.2016.10.027","article-title":"Evaluation of potent phytomedicine for treatment of psoriasis using UV radiation induced psoriasis in rats","volume":"84","author":"Nagar HK","year":"2016","unstructured":"Nagar HK, Srivastava AK, Srivastava R, et\u00a0al. Evaluation of potent phytomedicine for treatment of psoriasis using UV radiation induced psoriasis in rats. Biomed Pharmacother. 2016;84:1156\u20131162.","journal-title":"Biomed Pharmacother"},{"key":"e_1_3_5_3_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bjp.2014.07.010","article-title":"Anti-psoriatic activity of flavonoids from cassia tora leaves using the rat ultraviolet B ray photodermatitis model","volume":"24","author":"Vijayalakshmi A","year":"2014","unstructured":"Vijayalakshmi A, Geetha M. Anti-psoriatic activity of flavonoids from cassia tora leaves using the rat ultraviolet B ray photodermatitis model. Brazilian J Pharmacogn. 2014;24:322\u2013329.","journal-title":"Brazilian J Pharmacogn"},{"key":"e_1_3_5_4_1","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.12968\/bjon.2011.20.18.1186","article-title":"Management of psoriasis and its comorbidities in primary care","volume":"20","author":"Aldeen T","year":"2011","unstructured":"Aldeen T, Basra M. Management of psoriasis and its comorbidities in primary care. Br J Nurs. 2011;20:1186\u20131192.","journal-title":"Br J Nurs"},{"key":"e_1_3_5_5_1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3349\/ymj.2003.44.6.987","article-title":"Oxidant\/antioxidant status in patientes with psoriasis","volume":"44","author":"Baz K","year":"2003","unstructured":"Baz K, Cimen MYB, Kokturk A, et\u00a0al. Oxidant\/antioxidant status in patientes with psoriasis. Yonsei Med J. 2003; 44:987\u2013990.","journal-title":"Yonsei Med J"},{"key":"e_1_3_5_6_1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nature05663","article-title":"Pathogenesis and therapy of psoriasis","volume":"445","author":"Lowes MA","year":"2007","unstructured":"Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature. 2007;445:866\u2013873.","journal-title":"Nature"},{"key":"e_1_3_5_7_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/01913123.2014.952470","article-title":"Nuclear factor kappa B and cyclo-oxygenase-2: two concordant players in psoriasis pathogenesis","volume":"39","author":"Bakry OA","year":"2015","unstructured":"Bakry OA, Samaka RM, Shoeib MAM, et\u00a0al. Nuclear factor kappa B and cyclo-oxygenase-2: two concordant players in psoriasis pathogenesis. Ultrastruct Pathol. 2015;39:49\u201361.","journal-title":"Ultrastruct Pathol"},{"key":"e_1_3_5_8_1","article-title":"Rat ultraviolet ray B photodermatitis: an experimental model of psoriasis vulgaris","author":"Nakaguma H","unstructured":"Nakaguma H, Kambara T, Yamamoto T. Rat ultraviolet ray B photodermatitis: an experimental model of psoriasis vulgaris. Int J Exp Pathol.","journal-title":"Int J Exp Pathol"},{"key":"e_1_3_5_9_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1046\/j.1365-2133.1998.02447.x","article-title":"Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo","volume":"139","author":"Dreher F","year":"1998","unstructured":"Dreher F, Gabard B, Schwindt DA, et\u00a0al. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo. Br J Dermatol. 1998;139:332\u2013339.","journal-title":"Br J Dermatol"},{"key":"e_1_3_5_10_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/tox.20763","article-title":"The antioxidant effects of pumpkin seed oil on subacute aflatoxin poisoning in mice","volume":"28","author":"Eraslan G","year":"2013","unstructured":"Eraslan G, Kanbur M, Aslan \u00d6, et\u00a0al. The antioxidant effects of pumpkin seed oil on subacute aflatoxin poisoning in mice. Environ Toxicol. 2013;28:681\u2013688.","journal-title":"Environ Toxicol"},{"key":"e_1_3_5_11_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.foodres.2009.02.003","article-title":"Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts","volume":"42","author":"Xanthopoulou MN","year":"2009","unstructured":"Xanthopoulou MN, Nomikos T, Fragopoulou E, et\u00a0al. Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts. Food Res Int. 2009;42:641\u2013646","journal-title":"Food Res Int"},{"key":"e_1_3_5_12_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0024-3205(94)00666-0","article-title":"Melatonin: A peroxyl radical scavenger more effective than vitamin E","volume":"55","author":"Pieri C","year":"1994","unstructured":"Pieri C, Marra M, Moroni F, et\u00a0al. Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci. 1994;55:271\u2013276.","journal-title":"Life Sci"},{"key":"e_1_3_5_13_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2017.07.004","article-title":"Safety assessment and toxicological profiling of a novel combinational sunprotective dermal formulation containing melatonin and pumpkin seed oil","volume":"89","author":"Bora NS","year":"2017","unstructured":"Bora NS, Pathak MP, Mandal S, et\u00a0al. Safety assessment and toxicological profiling of a novel combinational sunprotective dermal formulation containing melatonin and pumpkin seed oil. Regul Toxicol Pharmacol. 2017;89:1\u201312.","journal-title":"Regul Toxicol Pharmacol"},{"key":"e_1_3_5_14_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2015.03.027","article-title":"Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis","volume":"85","author":"Sirerol JA","year":"2015","unstructured":"Sirerol JA, Feddi F, Mena S, et\u00a0al. Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis. Free Radic Biol Med. 2015;85:1\u201311.","journal-title":"Free Radic Biol Med"},{"key":"e_1_3_5_15_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.4103\/0253-7613.135949","article-title":"Anti-psoriatic activity of Givotia rottleriformis in rats","volume":"46","author":"Vijayalakshmi A","year":"2014","unstructured":"Vijayalakshmi A, Geetha M. Anti-psoriatic activity of Givotia rottleriformis in rats. Indian J Pharmacol. 2014;46:386.","journal-title":"Indian J Pharmacol"},{"key":"e_1_3_5_16_1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1365-2133.2004.05984.x","article-title":"The inflammatory response in mild and in severe psoriasis","volume":"150","author":"Rocha-Pereira P","year":"2004","unstructured":"Rocha-Pereira P, Santos-Silva A, Rebelo I, et\u00a0al. The inflammatory response in mild and in severe psoriasis. Br J Dermatol. 2004;150:917\u2013928.","journal-title":"Br J Dermatol"},{"key":"e_1_3_5_17_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10072-014-1991-2","article-title":"Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats","volume":"36","author":"Rahnama S","year":"2015","unstructured":"Rahnama S, Rabiei Z, Alibabaei Z, et\u00a0al. Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. Neurol Sci. 2015;36:553\u2013560.","journal-title":"Neurol Sci"},{"key":"e_1_3_5_18_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0891-5849(90)90131-2","article-title":"Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury","volume":"9","author":"Janero DR","year":"1990","unstructured":"Janero DR. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med. 1990;9:515\u2013540.","journal-title":"Free Radic Biol Med"},{"key":"e_1_3_5_19_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.foodchem.2009.01.015","article-title":"The effect of pacific cod (Gadus macrocephalus) skin gelatin polypeptides on UV radiation-induced skin photoaging in ICR mice","volume":"115","author":"Hou H","year":"2009","unstructured":"Hou H, Li B, Zhao X, et\u00a0al. The effect of pacific cod (Gadus macrocephalus) skin gelatin polypeptides on UV radiation-induced skin photoaging in ICR mice. Food Chem. 2009;115:945\u2013950.","journal-title":"Food Chem"},{"key":"e_1_3_5_20_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12291-012-0278-8","article-title":"Oxidative stress and skin cancer: an overview","volume":"28","author":"Narendhirakannan RT","year":"2013","unstructured":"Narendhirakannan RT, Hannah MAC. Oxidative stress and skin cancer: an overview. Indian J Clin Biochem. 2013;28:110\u2013115.","journal-title":"Indian J Clin Biochem"},{"key":"e_1_3_5_21_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jphotobiol.2015.10.006","article-title":"Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: an overview","volume":"153","author":"Goswami S","year":"2015","unstructured":"Goswami S, Haldar C. Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: an overview. J Photochem Photobiol B Biol. 2015;153:281\u2013288.","journal-title":"J Photochem Photobiol B Biol"},{"key":"e_1_3_5_22_1","volume-title":"Oxidants and antioxidants in cutaneous biology","author":"Thiele J","year":"2001","unstructured":"Thiele J, Elsner P, editors. Oxidants and antioxidants in cutaneous biology. 29th ed. Basel (Switzerland): Karger Medical and Scientific Publishers; 2001.","edition":"29"},{"key":"e_1_3_5_23_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/1043-6618(95)80051-4","article-title":"Effect of pumpkin-seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats","volume":"31","author":"Fahim A","year":"1995","unstructured":"Fahim A. Effect of pumpkin-seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats. Pharmacol Res. 1995;31:73\u201379.","journal-title":"Pharmacol Res"},{"key":"e_1_3_5_24_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1043-6618(02)00094-4","article-title":"Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat","volume":"46","author":"EL-Shenawy SM","year":"2002","unstructured":"EL-Shenawy SM, Abdel-Salam OME, Baiuomy AR, et\u00a0al. Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. Pharmacol Res. 2002;46:235\u2013243.","journal-title":"Pharmacol Res"},{"key":"e_1_3_5_25_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/bbrc.1996.1620","article-title":"Seleno compounds and glutathione peroxidase catalyzed decomposition of s-nitrosothiols","volume":"228","author":"Hou Y","year":"1996","unstructured":"Hou Y, Guo Z, Li J, et\u00a0al. Seleno compounds and glutathione peroxidase catalyzed decomposition of s-nitrosothiols. Biochem Biophys Res Commun. 1996;228:88\u201393.","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_3_5_26_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2147\/PTT.S122959","article-title":"Local effects of adipose tissue in psoriasis and psoriatic arthritis","volume":"7","author":"Kruglikov I","year":"2017","unstructured":"Kruglikov I, Wollina U. Local effects of adipose tissue in psoriasis and psoriatic arthritis. Psoriasis Targets Ther. 2017;7:17\u201325","journal-title":"Psoriasis Targets Ther"},{"key":"e_1_3_5_27_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/(SICI)1096-9896(199902)187:3<358::AID-PATH253>3.0.CO;2-8","article-title":"IL-1\u03b2 and IFN-\u03b3 induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system. IFN-\u0263 up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production","volume":"187","author":"Wei L","year":"1999","unstructured":"Wei L, Debets R, Hegmans JJ, et\u00a0al. IL-1\u03b2 and IFN-\u03b3 induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system. IFN-\u0263 up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production. J Pathol. 1999;187:358\u2013364.","journal-title":"J Pathol"},{"key":"e_1_3_5_28_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s004030050299","article-title":"An important role of tumor necrosis factor-alpha in the induction of adhesion molecules in psoriasis","volume":"290","author":"Terajima S","year":"1998","unstructured":"Terajima S, Higaki M, Igarashi Y, et\u00a0al. An important role of tumor necrosis factor-alpha in the induction of adhesion molecules in psoriasis. Arch Dermatol Res. 1998;290:246\u2013252.","journal-title":"Arch Dermatol Res"},{"key":"e_1_3_5_29_1","doi-asserted-by":"crossref","first-page":"7480","DOI":"10.4049\/jimmunol.162.12.7480","article-title":"IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder","volume":"162","author":"Hong K","year":"1999","unstructured":"Hong K, Chu A, Ludviksson BR, et\u00a0al. IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder. J Immunol. 1999;162:7480\u20137491.","journal-title":"J Immunol"},{"key":"e_1_3_5_30_1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1189\/jlb.0802397","article-title":"Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice","volume":"73","author":"Lin Z-Q","year":"2003","unstructured":"Lin Z-Q, Kondo T, Ishida Y, et\u00a0al. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol. 2003;73:713\u2013721.","journal-title":"J Leukoc Biol"},{"key":"e_1_3_5_31_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2340\/00015555-1931","article-title":"New drugs and treatment targets in psoriasis","volume":"95","author":"Kofoed K","year":"2015","unstructured":"Kofoed K, Skov L, Zachariae C. New drugs and treatment targets in psoriasis. Acta Derm Venerol. 2015;95:133\u2013139.","journal-title":"Acta Derm Venerol"},{"key":"e_1_3_5_32_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2310\/7750.2012.11124","article-title":"Phototherapy in psoriasis: a review of mechanisms of action","volume":"17","author":"Wong T","year":"2013","unstructured":"Wong T, Hsu L, Liao W. Phototherapy in psoriasis: a review of mechanisms of action. J Cutan Med Surg. 2013;17:6\u201312.","journal-title":"J Cutan Med Surg"}],"updated-by":[{"DOI":"10.1080\/08923973.2025.2556590","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000}}],"container-title":["Immunopharmacology and Immunotoxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/08923973.2019.1566358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T09:35:18Z","timestamp":1757410518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/08923973.2019.1566358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,2]]}},"alternative-id":["10.1080\/08923973.2019.1566358"],"URL":"https:\/\/doi.org\/10.1080\/08923973.2019.1566358","relation":{"correction":[{"id-type":"doi","id":"10.1080\/08923973.2025.2556590","asserted-by":"object"}]},"ISSN":["0892-3973","1532-2513"],"issn-type":[{"value":"0892-3973","type":"print"},{"value":"1532-2513","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iipi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iipi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}