{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:12:37Z","timestamp":1787958757160,"version":"build-2784847793"},"reference-count":71,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Surgery"],"published-print":{"date-parts":[[2022,3,4]]},"DOI":"10.1080\/08941939.2021.1908462","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T02:18:10Z","timestamp":1618193890000},"page":"605-613","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Roflumilast as a Potential Therapeutic Agent for Cecal Ligation and Puncture-Induced Septic Lung Injury"],"prefix":"10.1080","volume":"35","author":[{"given":"Zafer","family":"Bayraktutan","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Ataturk University","place":["Erzurum, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3365-7741","authenticated-orcid":false,"given":"Busra","family":"Dincer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Erzincan Binali Yildirim University","place":["Erzincan, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Child Health and Diseases, Ataturk University","place":["Erzurum, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Kose","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ataturk University","place":["Erzurum, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Bilen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ataturk University","place":["Erzurum, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Toktay","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Kafkas University","place":["Kars, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busra","family":"Sirin","sequence":"additional","affiliation":[{"name":"Clinical Research, Development and Design Application and Research Center, Ataturk University","place":["Erzurum, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ataturk University","place":["Erzurum, Turkey"]},{"name":"Department of Internal Medicine, Ataturk University","place":["Erzurum, Turkey"]},{"name":"Department of Histology and Embryology, Kafkas University","place":["Kars, Turkey"]},{"name":"Clinical Research, Development and Design Application and Research Center, Ataturk University","place":["Erzurum, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,4,11]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70239-6"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2017.17062"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200304000-00012"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/09680519060120030301"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2020.19218"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_2_8_1","first-page":"2526","article-title":"Acute respiratory distress syndrome","volume":"307","author":"Force ADT","year":"2012","unstructured":"Force ADT, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E. Acute respiratory distress syndrome. JAMA. 2012;307:2526\u20132533.","journal-title":"JAMA"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-013-0862-3"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2011.05.006"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9709092"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e2124"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31824ddc81"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S78757"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-36028-X_4"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2014-0607"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.3791\/2860"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/08941939.2015.1111474"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00123"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5005"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)29538-0"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90329.2008"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181959814"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03622-6"},{"key":"e_1_3_2_25_1","first-page":"1335","article-title":"Influence of roflumilast on sepsis mice through the JAK\/STAT signaling pathway","volume":"23","author":"Chang X","year":"2019","unstructured":"Chang X, Hu LF, Ma XJ, Yin J, Liu XY, Li JB. Influence of roflumilast on sepsis mice through the JAK\/STAT signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23:1335\u20131341.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2020.19391"},{"key":"e_1_3_2_27_1","doi-asserted-by":"crossref","unstructured":"Fabbri LM Begh\u00e9 B Yasothan U Kirkpatrick P. Roflumilast. Nat Rev Drug Discov. 2010;9(10):761\u2013762.","DOI":"10.1038\/nrd3276"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.03.018"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1078\/0940-2993-00247"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00289.2014"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2013.04.012"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-018-1571-8"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118177"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2015.07.006"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1943"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0782-3"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181c3cf0e"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985817726117"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0607373"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1997.01430280038005"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60331"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0069-0"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61255-1"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.075937"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.4.2005121"},{"key":"e_1_3_2_51_1","first-page":"A91","article-title":"Efficacy of the PDE4 inhibitor, BAY 19-8004 and a steroid in tobacco smoke-induced models of pulmonary inflammation in the mouse","volume":"167","author":"Fitzgerald MF","year":"2003","unstructured":"Fitzgerald MF, Spicer D, Henning R. Efficacy of the PDE4 inhibitor, BAY 19-8004 and a steroid in tobacco smoke-induced models of pulmonary inflammation in the mouse. Am J Respir Crit Care Med. 2003;167:A91.","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_2_52_1","first-page":"A91","article-title":"Efficacy of the PDE4 inhibitor, BAY 19-8004, in tobacco smoke models of COPD in the guinea pig","volume":"167","author":"Fox JC","year":"2003","unstructured":"Fox JC, Spicer D, Henning R, et\u00a0al. Efficacy of the PDE4 inhibitor, BAY 19-8004, in tobacco smoke models of COPD in the guinea pig. Am J Respir Crit Care Med. 2003;167:A91.","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2004.10.001"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-8-17"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2010.03.011"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707428"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)29537-9"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.232116"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.59"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2010.12.005"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-1014-0"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1024330"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.07.024"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.02.039"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.11.011"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00071307"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.06.017"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-18"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2013.09.007"},{"key":"e_1_3_2_70_1","first-page":"277","article-title":"The role of free radicals in sepsis development","volume":"1","author":"Andrades ME","year":"2009","unstructured":"Andrades ME, Ritter C, Dal-Pizzol F. The role of free radicals in sepsis development. Front Biosci (Elite Ed)). 2009;1:277\u2013287.","journal-title":"Front Biosci (Elite Ed))"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000201880.50116.12"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2008.00041.x"}],"container-title":["Journal of Investigative Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/08941939.2021.1908462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T05:44:02Z","timestamp":1757051042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/08941939.2021.1908462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,11]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,4]]}},"alternative-id":["10.1080\/08941939.2021.1908462"],"URL":"https:\/\/doi.org\/10.1080\/08941939.2021.1908462","relation":{},"ISSN":["0894-1939","1521-0553"],"issn-type":[{"value":"0894-1939","type":"print"},{"value":"1521-0553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iivs20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iivs20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}