{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:27:15Z","timestamp":1790501235622,"version":"4.1.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Great Lakes Fisheries Commission"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lake trout Salvelinus namaycush on thiamine-replete and thiamine-depleted diets were evaluated for the effects of thiamine status on in vivo responses to the T-dependent antigen trinitophenol (TNP)-keyhole limpet hemocyanin (TNP-KLH), the T-independent antigen trinitrophenol-lipolysaccaharide (TNP-LPS), or Dulbecco's phosphate-buffered saline (DPBS; negative control fish). Plasma antibody concentrations were evaluated for possible differences in total anti-TNP activity as well as differences in response kinetics. Associations between anti-TNP activity and muscle and liver thiamine concentrations as well as ratios of muscle-to-liver thiamine to anti-TNP activity were also examined. Thiamine-depleted lake trout that were injected with TNP-LPS exhibited significantly more anti-TNP activity than thiamine-replete fish. The depleted fish injected with TNP-LPS also exhibited significantly different response kinetics relative to thiamine-replete lake trout. No differences in activity or kinetics were observed between the thiamine-replete and -depleted fish injected with TNP-KLH or in the DPBS negative controls. Anti-TNP activity in thiamine-depleted lake trout injected with TNP-KLH was positively associated with muscle thiamine pyrophosphate (thiamine diphosphate; TPP) concentration. A negative association was observed between the ratio of muscle-to-liver TPP and T-independent responses. No significant associations between anti-TNP activity and tissue thiamine concentration were observed in the thiamine-replete fish. We demonstrated that thiamine deficiency leads to alterations in both T-dependent and T-independent immune responses in lake trout.<\/jats:p><jats:p>Received July 25, 2011; accepted July 12, 2012<\/jats:p>","DOI":"10.1080\/08997659.2012.713890","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T19:17:32Z","timestamp":1352315852000},"page":"258-273","source":"Crossref","is-referenced-by-count":25,"title":["Impact of Thiamine Deficiency on T-cell Dependent and T-cell Independent Antibody Production in Lake Trout"],"prefix":"10.1093","volume":"24","author":[{"given":"Christopher A.","family":"Ottinger","sequence":"first","affiliation":[{"name":"U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, West Virginia, 25430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale C.","family":"Honeyfield","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Leetown Science Center, Northern Appalachian Research Laboratory, Wellsboro, Pennsylvania, 16901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"Densmore","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, West Virginia, 25430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke R.","family":"Iwanowicz","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, West Virginia, 25430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,11,7]]},"reference":[{"key":"2025011310443955000_CIT0001","first-page":"2905","article-title":"Thiamin diphosphate in biological chemistry: analogues of thiamin diphosphate in studies of enzymes and riboswitches","volume":"276","author":"Agyei-Owusu","year":"2009","journal-title":"FEBS (Federation of European Biochemical Societies) Journal"},{"key":"2025011310443955000_CIT0002","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.vetimm.2008.07.013","article-title":"Fish immunity and parasite infections: from innate immunity to immunoprophylactic prospects","volume":"126","author":"Alvarez-Pellitero","year":"2008","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"2025011310443955000_CIT0003","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-445X(00)00089-8","article-title":"Hepatic activities othiamine-dependent enzymes, glucose-6-phosphate dehydrogenase and cytochrome p4501a in Baltic salmon (Salmo salar) yolk-sac fry after thiamine treatment","volume":"48","author":"Amcoff","year":"2000","journal-title":"Aquatic Toxicology"},{"key":"2025011310443955000_CIT0004","first-page":"1407","article-title":"Alterations of dopaminergic and serotondergic activity in the brain of sea-run Baltic salmon suffering a thiamine deficiency-related disorder","volume":"60","author":"Amcoff","year":"2002","journal-title":"Journal of Fish Biology"},{"key":"2025011310443955000_CIT0005","doi-asserted-by":"crossref","first-page":"17589","DOI":"10.1073\/pnas.0608757103","article-title":"Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage","volume":"103","author":"Ames","year":"2006","journal-title":"Proceeding of the National Academy of Sciences of the USA"},{"key":"2025011310443955000_CIT0006","first-page":"510","article-title":"Neuropathology and pathogensis of brain damage induced by thiamine deficiency","volume":"84","author":"Araki","year":"2010","journal-title":"Vitamins"},{"issue":"Supplement A","key":"2025011310443955000_CIT0007","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1095-8649.1987.tb05287.x","article-title":"Effect of early aflatoxin B1 exposure on in vivo and in vitro antibody responses in rainbow trout, Salmo gairdneri","volume":"31","author":"Arkoosh","year":"1987","journal-title":"Journal of Fish Biology"},{"key":"2025011310443955000_CIT0008","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0145-305X(91)90021-P","article-title":"Development of immunological memory in rainbow trout (Oncorhynchus mykiss). 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