{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:12:23Z","timestamp":1761844343575,"version":"3.33.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infectious pancreatic necrosis virus (IPNV) is one of the most important viruses in the Pacific salmon Oncorhynchus spp., Atlantic Salmon Salmo salar, and Rainbow Trout O. mykiss industry. This virus has been shown to produce high mortality among salmonid fry and juveniles, and survivors might become carriers. Since 2000, IPNV has affected Mexican Rainbow Trout culture, resulting in considerable economic losses. In the current study, molecular characterization of the VP2 gene of a number of Mexican IPNV isolates was done and the virus's phylogenetic relationships to IPNV reference strains were investigated. The phylogenetic analysis indicated that Mexican IPNV isolates are closely related to strains from the United States and Canada and that all Mexican IPNV isolates belong to genogroup 1. Furthermore, low genetic diversity was found between the Mexican isolates (identity, 95.8\u201399.8% nucleotides and 95.8\u201399.6% aminoacids). The result of the analysis of the amino acid residues found at positions 217, 221, and 247 (alanine, threonine, and glutamic acid, respectively) could be associated with virulence, although the expression of virulence factors is more complex and may be influenced by the agent and host factors. The high percentage of identity among the VP2 genes from geographically distant IPNV isolates and the evidence of wide distribution in the country might have been facilitated by carrier trout. This hypothesis is supported by the identification of the amino acid threonine at position 221 in all Mexican isolates, a factor related to the carrier state for IPNV, as reported by other studies.<\/jats:p>\n               <jats:p>Received July 14, 2013; accepted October 24, 2013<\/jats:p>","DOI":"10.1080\/08997659.2013.860060","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T17:22:36Z","timestamp":1396372956000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["Molecular Characterization of the VP2 Gene of Infectious Pancreatic Necrosis Virus (IPNV) Isolates from Mexico"],"prefix":"10.1093","volume":"26","author":[{"given":"Celene","family":"Salgado-Miranda","sequence":"first","affiliation":[{"name":"Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, D.F. 04510, Mexico; and Centro de Investigaci\u00f3n y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca, 50200, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Rojas-Anaya","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaciones Agr\u00edcolas Forestales y Pecuarias, Centro Nacional de Investigaci\u00f3n Disciplinaria en Microbiolog\u00eda Animal, M\u00e9xico, D.F. 05110, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Garc\u00eda-Espinosa","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Zootecnia de Aves, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, D.F. 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Loza-Rubio","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaciones Agr\u00edcolas Forestales y Pecuarias, Centro Nacional de Investigaci\u00f3n Disciplinaria en Microbiolog\u00eda Animal, M\u00e9xico, D.F. 05110, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"2025011310244349400_CIT0001","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/jfd.12072","article-title":"Tissue distribution of infectious pancreatic necrosis virus serotype Sp in naturally infected cultured Rainbow Trout, Oncorhynchus mykiss (Walbaum): an immunohistochemical and nested-PCR study","volume":"36","author":"Ahmadi","year":"2013","journal-title":"Journal of Fish Diseases"},{"key":"2025011310244349400_CIT0002","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/08997659.2011.644410","article-title":"Genotyping of infectious pancreatic necrosis virus isolates","volume":"23","author":"Barrera-Mej\u00eda","year":"2011","journal-title":"Journal of 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Que regula la aplicaci\u00f3n de cuarentenas, a efecto de prevenir la introducci\u00f3n y dispersi\u00f3n de enfermedades certificables y notificables, en la importaci\u00f3n de organismos acu\u00e1ticos vivos en cualesquiera de sus fases de desarrollo, destinados a la acuacultura y ornato en los Estados Unidos Mexicanos","year":"1993","author":"SAGARPA (Secretar\u00eda de Agricultura, Ganader\u00eda, Desarrollo Rural, Pesca y Alimentaci\u00f3n)","key":"2025011310244349400_CIT0036"},{"journal-title":"NOM-010-PESC-1993. 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