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On the other hand, it has been reported that immediate allergic reactions are caused by a GOS product (Bc-GOS) produced by treating lactose with \u03b2-galactosidase derived from Bacillus circulans. The objective of this study was to create a safer GOS product that is less likely to cause GOS-induced allergy (GOS-AL). First, we identified two derivatives of tetrasaccharide sugar chains in Bc-GOS as the factors responsible for GOS-AL by histamine release test (HRT) using blood samples obtained from two GOS-AL patients. Through our search for non-allergic GOS, we developed a new GOS product, SK-GOS, which was produced by catalyzing lactose with \u03b2-galactosidase derived from Sporobolomyces singularis and Kluyveromyces lactis. We regard it as a hypoallergic and safe GOS product that does not cause GOS-AL.<\/jats:p>","DOI":"10.1080\/09168451.2014.877819","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T19:00:30Z","timestamp":1398884430000},"page":"100-108","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":26,"title":["Development of hypoallergenic galacto-oligosaccharides on the basis of allergen analysis"],"prefix":"10.1080","volume":"78","author":[{"given":"Kimiyuki","family":"Kaneko","sequence":"first","affiliation":[{"name":"Yakult Central Institute for Microbiological Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Yakult Central Institute for Microbiological Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Kimura","sequence":"additional","affiliation":[{"name":"Yakult Central Institute for Microbiological Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Yakult Pharmaceuticals Industry Co., Ltd., Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mizobuchi","sequence":"additional","affiliation":[{"name":"Development Department, Yakult Honsha Co., Ltd., Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Onoue","sequence":"additional","affiliation":[{"name":"Yakult Central Institute for Microbiological Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"2021033107182163500_CIT0001","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","article-title":"Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics","volume":"125","author":"Gibson","year":"1995","journal-title":"J. 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