{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:53:48Z","timestamp":1785268428058,"version":"3.55.0"},"reference-count":24,"publisher":"Informa UK Limited","issue":"5","license":[{"start":{"date-parts":[[2014,5,4]],"date-time":"2014-05-04T00:00:00Z","timestamp":1399161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Transforming growth factor (TGF) \u03b21-induced plasminogen activator inhibitor (PAI)-1 is one of factors associated with the development of hepatic fibrosis. Calcitonin gene-related peptide (CGRP) shows hepatoprotective effect during hepatic injuries, including fibrosis. However, the effects of CGRP on PAI-1 expression induced by TGF\u03b21 are unknown. In this study, we investigated the effect of CGRP on TGF\u03b21-induced PAI-1 expression and its regulatory mechanisms in HepG2 cells. CGRP inhibited TGF\u03b21-induced PAI-1 expression. H89, a protein kinase A inhibitor, abolished the inhibition of TGF\u03b21-induced PAI-1 expression by CGRP. TGF\u03b21 activated mitogen-activated protein kinase (MAPK), including extracellular signal-regulated kinase, c-jun NH2-terminal kinase, and p38, and this activation was abolished by CGRP. These results show that the CGRP-induced cAMP\/PKA activation suppresses activation of MAPK induced by TGF\u03b21, leading to decreased PAI-1 expression in HepG2 cells.<\/jats:p>","DOI":"10.1080\/09168451.2014.910096","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T13:08:20Z","timestamp":1404392900000},"page":"787-790","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Calcitonin gene-related peptide regulates mitogen-activated protein kinase pathway to decrease transforming growth factor \u03b21-induced hepatic plasminogen activator inhibitor-1 mRNA expression in HepG2 cells"],"prefix":"10.1080","volume":"78","author":[{"given":"Sho","family":"Matsui","sequence":"first","affiliation":[{"name":"Faculty of Applied Bioscience, Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Yamane","sequence":"additional","affiliation":[{"name":"Faculty of Applied Bioscience, Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kobayashi-Hattori","sequence":"additional","affiliation":[{"name":"Faculty of Applied Bioscience, Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Oishi","sequence":"additional","affiliation":[{"name":"Faculty of Applied Bioscience, Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,5,4]]},"reference":[{"key":"2021033107000537300_CIT0001","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-230X-10-40","volume":"10","author":"Poynard","year":"2010","journal-title":"BMC Gastroenterol"},{"key":"2021033107000537300_CIT0002","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.2337\/dc12-0638","volume":"35","author":"Schneider","year":"2012","journal-title":"Diabetes Care"},{"key":"2021033107000537300_CIT0003","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1196\/annals.1378.039","volume":"1090","author":"Dimova","year":"2006","journal-title":"Ann. 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