{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:03:54Z","timestamp":1767841434106,"version":"3.49.0"},"reference-count":38,"publisher":"Informa UK Limited","issue":"7","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thioredoxin (TRX) is a redox regulating protein which has protective effects against oxidative stress-induced damage to cells and tissues. In this study, we investigated the effects of orally administered TRX derived from edible yeast, Saccharomyces cerevisiae, on gastric mucosa. First, we examined the digestibility of orally administered yeast TRX in mice, and detected yeast TRX in the stomach for 4\u2009h after administration. Next, we investigated the mitigation of gastric mucosal injury after the oral administration of yeast TRX in water-immersion restraint stress and HCl\/ethanol-induced gastric ulcer models. Furthermore, we conducted DNA microarray analysis, using the HCl\/ethanol-induced model, which revealed that several groups of genes related to tissue repair were upregulated in ulcer regions in the stomachs of rats administered with yeast TRX. These results demonstrated the viability of the use of oral administrations of yeast TRX to protect the gastric mucosa.<\/jats:p>","DOI":"10.1080\/09168451.2014.915733","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T17:26:50Z","timestamp":1403112410000},"page":"1221-1230","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury"],"prefix":"10.1080","volume":"78","author":[{"given":"Yukiko","family":"Taketani","sequence":"first","affiliation":[{"name":"Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., Nagahama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimihiro","family":"Kinugasa","sequence":"additional","affiliation":[{"name":"Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., Nagahama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., Nagahama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Nishiumi","sequence":"additional","affiliation":[{"name":"Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ashida","sequence":"additional","affiliation":[{"name":"Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, The Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuyosi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., Nagahama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., Nagahama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Masutani","sequence":"additional","affiliation":[{"name":"Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Yodoi","sequence":"additional","affiliation":[{"name":"Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan"},{"name":"Japan Biostress Research Promotion Alliance, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,7,3]]},"reference":[{"key":"2021033106463523000_CIT0001","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1046\/j.1432-1327.2000.01701.x","article-title":"Physiological functions of thioredoxin and thioredoxin reductase","volume":"267","author":"Arn\u00e9r","year":"2000","journal-title":"Eur. 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