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In this study, HepG2 cells transfected with expression plasmid of mouse constitutive androstane receptor (CAR) or PPAR\u03b1 were treated with CFA, phenobarbital (PB) or TCPOBOP. Luciferase assays showed that CFA increased CYP2B1 transcription to the same level as PB, or TCPOBOP in HepG2 transfected with mouse CAR But failed to induce it in PPAR\u03b1 transfected cells. CYP2B expressions were increased with PB or CFA in Wistar female rats (having normal levels of CAR) but not in Wistar Kyoto female rats (having low levels of CAR). The induction of CYP2B by PB or CFA was comparable to nuclear CAR levels. CAR nuclear translocation was induced by CFA in both rat strains. This indicates that fibrates can activate CAR and that fibrates-insulin sensitization effect may occur through CAR, while hypolipidemic effect may operate through PPAR\u03b1.<\/jats:p>","DOI":"10.1080\/09168451.2014.923302","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T14:18:00Z","timestamp":1402323480000},"page":"1550-1559","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Clofibric acid induces hepatic CYP 2B1\/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat"],"prefix":"10.1080","volume":"78","author":[{"given":"Zein Shaban","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Physiology, Kafrelsheikh University, Kafrelsheikh, Egypt"},{"name":"Faculty of Medicine, Departments of Physiology, Taif University, Taif, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Mohamed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Biochemistry, University of Sadat City, Egypt"},{"name":"Faculty of Science, Department of Biotechnology, Taif University, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir Ahmed","family":"El-Shazly","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biotechnology, Taif University, Kingdom of Saudi Arabia"},{"name":"Faculty of Veterinary Medicine, Department of Biochemistry, Kafrelsheikh University, Kafrelsheikh, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Ishizuka","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"2021033107180441300_CIT0001","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1345\/aph.1K013","article-title":"Evolution of peroxisome proliferator-activated receptor agonists","volume":"41","author":"Chang","year":"2007","journal-title":"Ann. 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