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We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp \u2192 Nam conversion compared with free-access control group; (2) the conversion of Trp \u2192 Nam is also increased by vitamin B1 deficiency compared with free-access control group. The present study was done to clarify whether or not a true reason about an increase in the Trp \u2192 Nam conversion is a vitamin B1 deficiency or severe food restriction. The present results showed that vitamin B1 deficiency suppressed the increased conversion of Trp \u2192 Nam induced by severe food restriction, probably by suppressing 3-hydroxyanthranilic acid 3,4-dioxygenase protein synthesis in liver.<\/jats:p>","DOI":"10.1080\/09168451.2014.962473","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T08:46:08Z","timestamp":1411634768000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats"],"prefix":"10.1080","volume":"79","author":[{"given":"Katsumi","family":"Shibata","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Fukuwatari","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"2021033115361681600_CIT0001","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3177\/jnsv.43.479","article-title":"Conversion ratio of tryptophan to niacin in rats fed a vitamin B1-free diet","volume":"43","author":"Shibata","year":"1997","journal-title":"J. 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